DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mRRF2 and HBS1

DIOPT Version :9

Sequence 1:	NP_732771.2	Gene:	mRRF2 / 42670	FlyBaseID:	FBgn0051159	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	493	Identity:	97/493 - (19%)
Similarity:	161/493 - (32%)	Gaps:	178/493 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SNQIWKRSYSSKIRNIG--ILAHIDAGKTTTTERMLFYAG------------KTRALG-EVHRGN 70
            :.|::::..:.:..:|.  ::.|:||||:|....:|:..|            :::.|| :.....
  Fly   233 ARQLYEKERADQKSHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQSFMYA 297

  Fly    71 TVTDYLTQERERGITICSSAVTFSWNDHRINLLDTPGHIDFTMEVEQSLYAVDGVVVVLDGTAGV 135
            .|.|...:||.||||:.............:.|||.|||.||...:.......|..::|:|.|.|.
  Fly   298 WVLDETGEERARGITMDVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQADVALLVVDATRGE 362

  Fly   136 EAQTVTVWSQADKHK-LPRLIFVNKMDRPDADFEKCVSDLKDKLETQPVCLQYPVKNEDGVLAIN 199
            ......:..|..:|. |.|.:.||::                                 ||: ||
  Fly   363 FESGFELGGQTREHAILVRSLGVNQL---------------------------------GVV-IN 393

  Fly   200 DVITLERLSWQQ--------------KDLGRSYRNVKLEPSDDL--RLLQEKRNE--LIDQLSGL 246
               .|:.:.|.|              |..|....:|...|...|  ..|.:|..|  |.:..||
  Fly   394 ---KLDTVGWSQDRFTEIVTKLKSFLKLAGFKDSDVSFTPCSGLTGENLTKKAQEPALTNWYSG- 454

  Fly   247 DDELADVVISTESFDNVDNALIERALRRATT----------------QQKVV----PVLLGSAYK 291
             ..|.||:   |:| .:....|:|.||.:.:                :..|:    .||:|::.:
  Fly   455 -RHLLDVI---ENF-KIPERAIDRPLRMSVSDIYKGTGSGFCISGRVETGVLCLNDKVLVGASRE 514

  Fly   292 NVGIQRLM------------DAVNAYLPAPEERNQIYDCFGTEVAGKVFKIVHDKQRGPLTLVRI 344
            ...::.|.            |.|:..|||.:..|....|           |:.|.|. |:.
  Fly   515 QAQVKSLTMNEFPQTCVFAGDQVSVTLPALDINNVTVGC-----------IISDPQT-PIP---- 563

  Fly   345 LRGEIKRGMRLISARGQAEVV------------------SKLYEPLADEYREVSAVQSGDVVICA 391
                       ::.|.||.::                  ..|.||               .|:|
  Fly   564 -----------VTTRFQARIIVFNVKVPITMGFPVLLHHQSLIEP---------------AVVC- 601

  Fly   392 GLKSTVTGDLLTSSQSALKNAQKRYKQSLGNTAAKVEE 429
                    .|..|...:.....|:..:.|||.:..:.|
  Fly   602 --------KLTASIHKSTGEVVKKKPRCLGNNSCALVE 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRRF2	NP_732771.2	PRK12739	31..733	CDD:237185	96/483 (20%)
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079
		TEF1	241..669	CDD:227581	96/485 (20%)
		EF1_alpha	249..468	CDD:206670	60/261 (23%)
		HBS1-like_II	474..557	CDD:293912	15/93 (16%)
		HBS1_C_III	561..669	CDD:294008	16/110 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464607
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840