DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mRRF2 and Gfm1

DIOPT Version :9

Sequence 1:	NP_732771.2	Gene:	mRRF2 / 42670	FlyBaseID:	FBgn0051159	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_446077.2	Gene:	Gfm1 / 114017	RGDID:	631396	Length:	751	Species:	Rattus norvegicus

Alignment Length:	771	Identity:	237/771 - (30%)
Similarity:	382/771 - (49%)	Gaps:	92/771 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 WQSGPKQSN--RWLWHLSNQIWKRSYSSKIRNIGILAHIDAGKTTTTERMLFYAGKTRALGEVHR 68
            ||.  ||:|  .:.|..|..|    .:.|||||||.||||:||||.|||:|:|.|:...:.|| :
  Rat    24 WQG--KQANWKTYRWCSSGSI----PNEKIRNIGISAHIDSGKTTLTERVLYYTGRIATMHEV-K 81

  Fly    69 G----NTVTDYLTQERERGITICSSAVTFSWNDHRINLLDTPGHIDFTMEVEQSLYAVDGVVVVL 129
            |    ..|.|.:..||:|||||.|:|....|.|..||::|||||:|||:|||::|..:||.|:||
  Rat    82 GKDGVGAVMDSMELERQRGITIQSAATYTMWRDVNINIIDTPGHVDFTIEVERALRVLDGAVLVL 146

  Fly   130 DGTAGVEAQTVTVWSQADKHKLPRLIFVNKMDRPDADFEKCVSDLKDKLETQPVCLQYPVKNEDG 194
            ....||:.||:||..|..::.:|.|.|:||:||..::..:.:..::.||......:|.|:..|..
  Rat   147 CAVGGVQCQTMTVSRQMKRYNVPFLTFINKLDRMGSNPARALQQMRSKLNHNAAFVQIPIGLEGD 211

  Fly   195 VLAINDVITLERLSWQQKDLGRSYRNVKLEPSDDLRLLQEKRNELIDQLSGLDDELADVVISTES 259
            ...|.|:|. ||..:...|.|:..|..:: |:|......:.|.|||:.::..|::|.::.:. |.
  Rat   212 FKGIIDLIE-ERAIYFDGDFGQIVRYDEI-PADLRAAAADHRQELIECVANSDEQLGELFLE-EK 273

  Fly   260 FDNVDNALIERALRRATTQQKVVPVLLGSAYKNVGIQRLMDAVNAYLPAPEERNQIYDCFGTEVA 324
            ..:|.:  ::.|:||||..:...||.||||.||.|:|.|:|||..:||.|.| .|.|.......:
  Rat   274 IPSVSD--LKLAIRRATLSRSFTPVFLGSALKNKGVQPLLDAVLEFLPNPSE-VQNYALLNQNDS 335

  Fly   325 GKVFKIVHDKQR------------------GPLTLVRILRGEIKRGMRLISAR-GQAEVVSKLYE 370
            .:..||:.:.:|                  |.||.||..:||:|:|..:.:.| |:...|.:|..
  Rat   336 KEKNKILMNPKRDDSHPFVGLAFKLEAGRFGQLTYVRNYQGELKKGSTIYNTRTGKKVRVQRLVR 400

  Fly   371 PLADEYREVSAVQSGDVVICAGLKSTVTGDLLTSSQSALKNAQKRYKQSLGNTAAKVEEDDELDE 435
            ..||...:|..|.:||:....|: ...:||..|:.                            |.
  Rat   401 MHADMMEDVEEVYAGDICALFGI-DCASGDTFTNK----------------------------DN 436

  Fly   436 SDELFAIDPQIPDAVYFCSIEPPSVSSQTAMEQALKQLQREDPSLRVSYDSVTGQTVLGGMGELH 500
            || |......:||.|...:::|.:.:......:.:.:..||||:.:|.:|:.:.:|::.||||||
  Rat   437 SD-LSMESIHVPDPVISVAMKPSNKNDLEKFSKGIARFTREDPTFKVHFDTESKETIVSGMGELH 500

  Fly   501 MDIIKSRILSEYKIDVDLGPLQIAYKETIEAPALTTLSVEKEIAGSKQ--SVSITLEVV--KNQA 561
            ::|...|:..||......|..::|::||:.||.....:.:|:..|:.|  .|...||.:  ::..
  Rat   501 LEIYAQRMEREYGCPCITGKPKVAFRETVTAPVPFDFTHKKQSGGAGQYGKVIGVLEPLAPEDYT 565

  Fly   562 EL-FSLDKSPDNLPNLNTLRPRILQVLRKGSISALERGPRVGGQVVETQIRLHNAT--IGRGTAD 623
            :| ||.:....|:|.      :.:..:.||.:.|.|:||..|.::...:..|.:..  :......
  Rat   566 KLEFSDETFGANVPK------QFVPAVEKGFLDACEKGPLSGHKLSGLRFVLQDGAHHMVDSNEI 624

  Fly   624 SFVMATAAQCVQKLLSTSGTRLLEPIMALQIVAPSERISGIMADLSRRRALI--NDVLPKGERNK 686
            ||:.|......|.|.|.: ..::||||:::::||:|....:.|.::||..:|  .|.:   |...
  Rat   625 SFIRAGEGALKQALASAT-LCIIEPIMSVEVIAPNEFQGAVFAGINRRHGVITGQDGI---EDYF 685

  Fly   687 MILVNAPLAELSGYSSALRTISSGTASMTM-----QPCGFSSMNSVDESLAERRAQ 737
            .:..:.||..:.|||:.||:.:.|....||     |||..|:...:.....|...|
  Rat   686 TLYADVPLNNMFGYSTELRSCTEGKGEYTMEYNRYQPCSPSTQEELVNKYLEATGQ 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRRF2	NP_732771.2	PRK12739	31..733	CDD:237185	227/738 (31%)
Gfm1	NP_446077.2	PRK12740	53..732	CDD:237186	220/725 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D220174at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920