DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31156 and EEPD1

DIOPT Version :9

Sequence 1:	NP_651070.3	Gene:	CG31156 / 42669	FlyBaseID:	FBgn0051156	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_085139.2	Gene:	EEPD1 / 80820	HGNCID:	22223	Length:	569	Species:	Homo sapiens

Alignment Length:	263	Identity:	67/263 - (25%)
Similarity:	105/263 - (39%)	Gaps:	89/263 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   638 KMDTNERSAVSIARRLNDPLSEYVKIEPRHLGVGMYQHDVPEKILTASLNDVVSECVSYVGVDLN 702
            |..:.:.|..|:.|   |.|:|.   :|.||...     ||   ||..:|             :|
Human   103 KGSSAQHSPSSLRR---DLLAEQ---QPHHLATA-----VP---LTPRVN-------------IN 140

  Fly   703 TASLSVLKHIAGLSEKKAEKIIEHRTQKGPFKTRKDLLSVRSIGEKSFVQCAGFV---------- 757
            ||:.:.|..:.|||||.|..|::.|.:.|||::.:||:.:..|.       |.|:
Human   141 TATPAQLMSVRGLSEKMALSIVDFRREHGPFRSVEDLVRMDGIN-------AAFLDRIRHQVFAE 198

  Fly   758 RIEPRSV---GGQLQNPLDCTWV---HPESYNVVESIVGECDLKLSDVGKAAFIA---SIKQFAS 813
            |..|.|.   ||       .|:.   ||...::  |:..| ||.|...|....|:   |::.|..
Human   199 RSRPPSTHTNGG-------LTFTAKPHPSPTSL--SLQSE-DLDLPPGGPTQIISTRPSVEAFGG 253

  Fly   814 S---QPNLDRIAK----------------QHKLPMERLE--FLLVALQ----RELLQDYRADLDK 853
            :   :|.| |:|.                :..:.|..||  ..|:|:|    ||.|:.:..:|::
Human   254 TRDGRPVL-RLATWNLQGCSVEKANNPGVREVVCMTLLENSIKLLAVQELLDREALEKFCTELNQ 317

  Fly   854 RPL 856
            ..|
Human   318 PTL 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31156	NP_651070.3	Tex	184..931	CDD:225094	67/263 (25%)
		Tex_N	190..362	CDD:286460
		Tex_YqgF	527..653	CDD:293526	4/14 (29%)
		HHH_3	697..758	CDD:289597	20/70 (29%)
		S1_like	870..930	CDD:299122
EEPD1	NP_085139.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		ComEA	<31..100	CDD:224472
		HHH_3	37..95	CDD:289597
		comE	69..195	CDD:213597	35/125 (28%)
		HHH_3	136..195	CDD:289597	21/78 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..225		7/33 (21%)
		MnuA_DNase1-like	261..538	CDD:197338	14/61 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..569
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2183
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900