DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG31156 and SUPT6H

DIOPT Version :9

Sequence 1:NP_651070.3 Gene:CG31156 / 42669 FlyBaseID:FBgn0051156 Length:948 Species:Drosophila melanogaster
Sequence 2:NP_001307684.1 Gene:SUPT6H / 6830 HGNCID:11470 Length:1726 Species:Homo sapiens


Alignment Length:1366 Identity:255/1366 - (18%)
Similarity:449/1366 - (32%) Gaps:515/1366 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 TKKIVIE-----------ISDSDEEVNLTA---DDDYRPEETKSRIIDRAADAQTVVTKRQRFPT 61
            |||.|.|           :.|.||:.||..   |||...|..:....| :.|::..|..::|   
Human    27 TKKFVEEEDDDEEEEEENLDDQDEQGNLKGFINDDDDEDEGEEDEGSD-SGDSEDDVGHKKR--- 87

  Fly    62 SKKTA-------------AEGPAPKKKRG-----------DKEKADENACPNENNPESVVQDTPS 102
             |:|:             .|....|.|||           |::..:|.....|:..|::.::...
Human    88 -KRTSFDDRLEDDDFDLIEENLGVKVKRGQKYRRVKKMSDDEDDDEEEYGKEEHEKEAIAEEIFQ 151

  Fly   103 TSNQRNGAVGTEHNSEAP-APKRKRARKDKED------------------------------LKT 136
            ......|    :...||| ||..:....|:|.                              |:.
Human   152 DGEGEEG----QEAMEAPMAPPEEEEEDDEESDIDDFIVDDDGQPLKKPKWRKKLPGYTDAALQE 212

  Fly   137 AA---------------NETNPE------------KGDVVPSTAVT--------------QPNDI 160
            |.               ||.:.|            :|::......|              :|:::
Human   213 AQEIFGVDFDYDEFEKYNEYDEELEEEYEYEDDEAEGEIRVRPKKTTKKRVSRRSIFEMYEPSEL 277

  Fly   161 VASSSHNKSSTGRSS-FWERRKVWNI-------DELLAETESI---------------------- 195
            .:|...::.:..|:: ..||.::.:|       |||..|.:.|                      
Human   278 ESSHLTDQDNEIRATDLPERFQLRSIPVKGAEDDELEEEADWIYRNAFATPTISLQESCDYLDRG 342

  Fly   196 QPQAA------RNIVKLFE-------DENTIPFICRYRRDLVDHIAPD-RLRDIRNTY---TEIV 243
            ||.::      ..|.|:.|       ....:|||..||::.|:   |: .:.|:...:   .:..
Human   343 QPASSFSRKGPSTIQKIKEALGFMRNQHFEVPFIAFYRKEYVE---PELHINDLWRVWQWDEKWT 404

  Fly   244 DLRKRAENI------IGKLQRENI-------MTPEIR-------EELMCAKSNEELEFLYAPY-- 286
            .||.|.||:      :...|.|.|       :...||       |.|...:|.:||:.:|..:  
Human   405 QLRIRKENLTRLFEKMQAYQYEQISADPDKPLADGIRALDTTDMERLKDVQSMDELKDVYNHFLL 469

  Fly   287 ----------------------------------------------KPASKGTLAERAKALGLQV 305
                                                          |.||:..:....::.||..
Human   470 YYGRDIPKMQNAAKASRKKLKRVREEGDEEGEGDEAEDEEQRGPELKQASRRDMYTICQSAGLDG 534

  Fly   306 YADCLLYGSAPK---VNLSEIVDR-RNEALATEAL----------------VMSGICQIIIHNIS 350
            .|.  .:|..|:   .||.:...| ..|....|.|                |:.|...::...|:
Human   535 LAK--KFGLTPEQFGENLRDSYQRHETEQFPAEPLELAKDYVCSQFPTPEAVLEGARYMVALQIA 597

  Fly   351 KNTNVLEEIRRLQNVHRVFLKCSKTKEAKSSKSSSSSKASSSKGSNQNADKKLDSSKFENYFNF- 414
            :...|.:.:|:... .|..|..:.||:.:                     |.:|.:.:...|.: 
Human   598 REPLVRQVLRQTFQ-ERAKLNITPTKKGR---------------------KDVDEAHYAYSFKYL 640

  Fly   415 -QGDVKTIKPYQMLAINRGEKHKWLSVKIET---------ND--YLKRDLMRYITDQYMNQGLQY 467
             ...||.::..|.|.|...|....|:..|..         ||  |.:.....|..|::.:|..::
Human   641 KNKPVKELRDDQFLKICLAEDEGLLTTDISIDLKGVEGYGNDQTYFEEIKQFYYRDEFSHQVQEW 705

  Fly   468 PLRREVFTKSLEECYAKKLQPLMCRQIRAALKEKGTKAAIDVFAKNLKQLLLISPL--------- 523
            ..:|   |.::|....:.|...|.::::..|..:..:..|...::.|...|.::|.         
Human   706 NRQR---TMAIERALQQFLYVQMAKELKNKLLAEAKEYVIKACSRKLYNWLRVAPYRPDQQVEED 767

  Fly   524 ---------KGERILGI-------DPGF---INGCKLALISETADVLYTGVIYPHGA-------- 561
                     ||.|:|||       .|.|   :||     ..|..|.|.    .||..        
Human   768 DDFMDENQGKGIRVLGIAFSSARDHPVFCALVNG-----EGEVTDFLR----LPHFTKRRTAWRE 823

  Fly   562 ----------------MSNKR------AAEQKLVQLLSDHNCKIIGLGNGTACRETEHWLTGMFH 604
                            :.||:      |.|.:..|:|.:...:|:            |.|.   .
Human   824 EEREKKAQDIETLKKFLLNKKPHVVTVAGENRDAQMLIEDVKRIV------------HELD---Q 873

  Fly   605 AGVLDSRIIRYSIVNENGASIYSCSNVAAKEFPKMDTNERSAVSIARRLNDPLSEY--------- 660
            ...|.|  |...:|:...|.:|..|..:..||.......|.|||:|||:.|||.|:         
Human   874 GQQLSS--IGVELVDNELAILYMNSKKSEAEFRDYPPVLRQAVSLARRIQDPLIEFAQVCSSDED 936

  Fly   661 ---VKIEPRHLGVGMYQHDVPEKILTASLNDVVSECVSYVGVDLNTA-----SLSVLKHIAGLSE 717
               :|..|      :.:|.|.|::|.|...:.::. |:.||||:|.|     |.::::::.||..
Human   937 ILCLKFHP------LQEHVVKEELLNALYCEFINR-VNEVGVDVNRAIAHPYSQALIQYVCGLGP 994

  Fly   718 KKAEKIIEHRTQKGP-FKTRKDLLSVRSIGEKSFVQCAGFVRIEPRSVGGQLQN---PLDCTWVH 778
            :|...:::...|... .::|..|:::..:|.|.|:.||||::|:..|:|....:   .||.:.||
Human   995 RKGTHLLKILKQNNTRLESRTQLVTMCHMGPKVFMNCAGFLKIDTASLGDSTDSYIEVLDGSRVH 1059

  Fly   779 PESYN-----VVESIVGECDLKLSDVGKAAFIASIKQFASSQPNLDRIAKQHKLPMERLEFLLVA 838
            ||:|.     .|:::  |.|....|...|..:..|.:......:||            |:.....
Human  1060 PETYEWARKMAVDAL--EYDESAEDANPAGALEEILENPERLKDLD------------LDAFAEE 1110

  Fly   839 LQRE-------LLQDYRADL-----DKRPLFKQGLTR----------LDDLSMGEVVTGAVTNVT 881
            |:|:       .|.|.||:|     |.|..::...|.          .:...:|:::...||.:.
Human  1111 LERQGYGDKHITLYDIRAELSCRYKDLRTAYRSPNTEEIFNMLTKETPETFYIGKLIICNVTGIA 1175

  Fly   882 --------------------------QFGAFVD-----------------VGVER------NGLI 897
                                      |...|.:                 :||:.      .|.|
Human  1176 HRRPQGESYDQAIRNDETGLWQCPFCQQDNFPELSEVWNHFDSGSCPGQAIGVKTRLDNGVTGFI 1240

  Fly   898 HNSNMNN-------SQLSVGDRIVASVVKVDLKRRQLEL--RLENML-------METDTSFKFKA 946
            ....:::       .::.||..:...::|:|:::...:|  |..:::       :..||.:.|.|
Human  1241 PTKFLSDKVVKRPEERVKVGMTVHCRIMKIDIEKFSADLTCRTSDLMDRNNEWKLPKDTYYDFDA 1305

  Fly   947 E 947
            |
Human  1306 E 1306

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31156NP_651070.3 Tex 184..931 CDD:225094 200/1057 (19%)
Tex_N 190..362 CDD:286460 50/298 (17%)
Tex_YqgF 527..653 CDD:293526 37/165 (22%)
HHH_3 697..758 CDD:289597 20/66 (30%)
S1_like 870..930 CDD:299122 14/117 (12%)
SUPT6HNP_001307684.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..199 37/180 (21%)
Interaction with PAAF1. /evidence=ECO:0000269|PubMed:22316138 2..916 170/953 (18%)
Interaction with IWS1. /evidence=ECO:0000250 2..485 84/469 (18%)
Interaction with KDM6A. /evidence=ECO:0000250 317..1300 197/1059 (19%)
HTH_44 <348..422 CDD:291314 16/76 (21%)
Tex 372..1353 CDD:225094 195/1012 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 484..520 2/35 (6%)
Tex_N <565..623 CDD:286460 10/58 (17%)
YqgF 775..931 CDD:258777 44/181 (24%)
HHH_7 935..1038 CDD:291309 28/109 (26%)
DLD 1053..1157 CDD:291540 26/117 (22%)
S1 <1227..1282 CDD:197648 9/54 (17%)
SH2_2 1304..1514 CDD:291307 2/3 (67%)
SH2_Nterm_SPT6_like 1331..1415 CDD:198174
SH2_Cterm_SPT6_like 1424..1515 CDD:198182
Interaction with histone H2B and H3. /evidence=ECO:0000269|PubMed:10933715 1633..1726
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1636..1726
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2183
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56990at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.