DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31156 and Srbd1

DIOPT Version :9

Sequence 1:	NP_651070.3	Gene:	CG31156 / 42669	FlyBaseID:	FBgn0051156	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	XP_006239770.1	Gene:	Srbd1 / 301665	RGDID:	1562788	Length:	983	Species:	Rattus norvegicus

Alignment Length:	993	Identity:	343/993 - (34%)
Similarity:	527/993 - (53%)	Gaps:	112/993 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EISDSDEEVNLTADDDYRPEETKSRIIDRAADAQTVVTKRQRFPTSKKTAAEGPAPKKKRGDKEK 81
            |:|...||.| ..|..:.|::...|...|.|...   :||::.|..||:|.:.....|....||:
  Rat    29 ELSSGSEEDN-KEDSIWEPQKKVLRNRRRPASKG---SKRKQGPRVKKSAQQVHDISKDVAVKEE 89

  Fly    82 ADE-----NACPNENNPESVVQDTPST---------------------SNQRNGAVGTEHNSEAP 120
            .:.     ||...|.|.:....:|..|                     :||.:...|.|.|.|||
  Rat    90 LNSPVAIVNANLEEENQKLHTTNTLKTAAKKQKNAGHGAKKRLKVDEETNQASPFEGGESNVEAP 154

  Fly   121 APKRKR--ARKDKEDLKTAANETNPEKGDVVPSTAVTQPNDIVASSSHNKSSTGRSSFWERRKVW 183
            :....|  .:|:.||..|.  |.:|.|.....|....:|..:..:|...:         |....|
  Rat   155 STSEDRDMCKKESEDSFTF--EQSPLKRIKTESCPQGRPARVPGASDIKE---------EVEMNW 208

  Fly   184 NIDELLAETESIQPQAARNIVKLFEDENTIPFICRYRRDLVDHIAPDRLRDIRNTYTEIVDLRKR 248
            :|.::|:|..:|:|....||::||.|:||||||.|||::|::::..|.||::|.|..|:.|:.|:
  Rat   209 DIVQVLSERTNIEPWICANIIRLFNDDNTIPFIVRYRKELINNLDADFLREVRQTLDELRDVAKK 273

  Fly   249 AENIIGKLQRENIMTPEIREELMCAKSNEELEFLYAPYKPASKGTLAERAKALGLQVYADCLLYG 313
            ..:.|.|:::|..|:..:.:.|:..|:.||||.:.||||..||||.|:|||.|||:..|..||..
  Rat   274 VHSRIQKIKKEGKMSECLLQALLNCKTFEELEHVSAPYKMGSKGTKAQRAKQLGLEGAAWTLLEN 338

  Fly   314 SAPKVNLSEIVDRRNEALATEALVMSGICQIIIHNISKNTNVLEEIRRLQNVHRVFLKCSKTKEA 378
            .. ::||...:....:.|:....:.:|:..|:...|:|:.:.|:.||.|.. ||..  |.:
  Rat   339 PG-QLNLPSYIRPDVKGLSELKDIETGVQHILADMIAKDKDTLDFIRDLCK-HRYI--CIQ---- 395

  Fly   379 KSSKSSSSSKASSSKGSNQNADKKLDSSKFENYFNFQGDVKTIKPYQMLAINRGEKHKWLSVKIE 443
                 ||.:|.||.|.:.:..|      ||:.|.||..:::.|..:|:|||||||..|.|:||:.
  Rat   396 -----SSLAKVSSKKVNEKEVD------KFQLYQNFSCNIRNIHHHQILAINRGENLKILTVKVN 449

  Fly   444 TNDYLKRDLMRY-ITDQYMNQGLQYPLRREVFTKSLEECYAKKLQPLMCRQIRAALKEKGTKAAI 507
            .:|.:|.:..|: |.:::..:|...|...::...||::.:.:.:.||:||::||.|.....|.::
  Rat   450 ISDGVKNEFCRWCIQNRWRPRGFARPELMKILHNSLDDSFKRLIVPLLCRELRAKLTSDAEKQSV 514

  Fly   508 DVFAKNLKQLLLISPLKGERILGIDPGFINGCKLALISETADVLYTGVIYPHGAMSNKRAAEQKL 572
            .:|.:||:||||.||:.|..::|:|||:.:|||||:||.|:.:|:|.|:|.|.....:.|  :|:
  Rat   515 MMFGQNLRQLLLTSPVPGRTLMGVDPGYKHGCKLAIISPTSQILHTDVVYLHCGQGFREA--EKI 577

  Fly   573 VQLLSDHNCKIIGLGNGTACRETEHWLTGMFHAGVLDSRIIRYSIVNENGASIYSCSNVAAKEFP 637
            .:||.:.||..:.:||||||||||.:...:..........:.|.||:|.||||||.|..|.||.|
  Rat   578 KRLLLNFNCNTVVIGNGTACRETEAYFADLIMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMP 642

  Fly   638 KMDTNERSAVSIARRLNDPLSEYVKIEPRHLGVGMYQHDVPEKILTASLNDVVSECVSYVGVDLN 702
            .:|.|.|||||||||:.|||:|.||.:|:|:|||||||||.:.:|.|:|:.||.||||:||||:|
  Rat   643 GLDPNLRSAVSIARRVQDPLAELVKFDPKHIGVGMYQHDVSQTLLKATLDSVVEECVSFVGVDIN 707

  Fly   703 TASLSVLKHIAGLSEKKAEKIIEHRTQKGPFKTRKDLLSVRSIGEKSFVQCAGFVRIEPRSV--- 764
            ..|..:|:|||||:..:|:.|||.|.:.|||..|:.|..|:.:|.|||.|||||||:....:
  Rat   708 ICSEVLLRHIAGLNANRAKNIIEWREKNGPFINREQLKKVKGLGPKSFQQCAGFVRVNQDYIRTF 772

  Fly   765 --------GGQLQ-----------------------NPLDCTWVHPESYNVVESIVGECDLKLSD 798
                    .||.|                       ||||.|.:|||||::....:......|.:
  Rat   773 CSGQHTDSSGQSQEAAMVTKEKPGKKKNKADVALTPNPLDETCIHPESYDIAVRFLSFIGGTLYE 837

  Fly   799 VGKAAFIASIKQFASSQPNLDRIAKQHKLPMERLEFLLVALQRELLQDYRADLDKRPLFKQGLTR 863
            :||......|.. :..:..:::.|::.:.....|:.::..|.:....|.|.|.|| |.||:.:..
  Rat   838 IGKPEMQQKINS-SLGKEGIEKTAERLQTTAHTLQVIIDGLSQPKTFDIRTDFDK-PDFKRSIVC 900

  Fly   864 LDDLSMGEVVTGAVTNVTQFGAFVDVGVERNGLIHNSNMNNSQLS-----------VGDRIVASV 917
            |.||.:|.::||.|.|.|.||.|||:||.:.|||....:..::||           .|:::...|
  Rat   901 LADLQVGTILTGKVENATLFGVFVDIGVGKAGLIPIRFITEAKLSKTKKRRSLGLGPGEKVEVKV 965

  Fly   918 VKVDLKRRQLELRLENML 935
            :.||:.|.::.|.|..:|
  Rat   966 LSVDIPRSRISLDLLRVL 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31156	NP_651070.3	Tex	184..931	CDD:225094	295/792 (37%)
		Tex_N	190..362	CDD:286460	64/171 (37%)
		Tex_YqgF	527..653	CDD:293526	58/125 (46%)
		HHH_3	697..758	CDD:289597	32/60 (53%)
		S1_like	870..930	CDD:299122	23/70 (33%)
Srbd1	XP_006239770.1	Tex	206..980	CDD:225094	296/796 (37%)
		Tex_N	215..410	CDD:286460	74/207 (36%)
		Tex_YqgF	534..659	CDD:293526	59/126 (47%)
		HHH_3	701..763	CDD:289597	32/61 (52%)
		S1_Tex	907..978	CDD:240190	23/70 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350798
Domainoid	1	1.000	114	1.000	Domainoid score	I5955
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9994
Inparanoid	1	1.050	506	1.000	Inparanoid score	I1286
OMA	1	1.010	-	-		QHG62824
OrthoDB	1	1.010	-	-		D321814at33208
OrthoFinder	1	1.000	-	-		FOG0006115
OrthoInspector	1	1.000	-	-		oto95612
orthoMCL	1	0.900	-	-		OOG6_104871
Panther	1	1.100	-	-	LDO	PTHR10724
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5053
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.870