DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31156 and Supt6

DIOPT Version :9

Sequence 1:	NP_651070.3	Gene:	CG31156 / 42669	FlyBaseID:	FBgn0051156	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_033323.2	Gene:	Supt6 / 20926	MGIID:	107726	Length:	1726	Species:	Mus musculus

Alignment Length:	1213	Identity:	241/1213 - (19%)
Similarity:	418/1213 - (34%)	Gaps:	420/1213 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SDSDEEVNLTADDDYRPEETKSRIIDRAADAQTVVTKRQRFPTSKKTAAEGPAPKKKRGDKEKAD 83
            ::.|||  |..|.:|..:||:..|..|                .|||.       |||..:....
Mouse   230 NEYDEE--LEEDYEYEDDETEGEIRVR----------------PKKTT-------KKRVSRRSIF 269

  Fly    84 ENACPNENNPESVVQDTPSTSNQRNGAVGTEHNSEAPAPKRKRARKDKEDLKTAANETNPEKGDV 148
            |...|:|       .::...::|.|....|:      .|:|.:.|  ...:|.|.::...|:.|.
Mouse   270 EMYEPSE-------LESSHLTDQDNEIRATD------LPERFQLR--SIPVKAAEDDELEEEADW 319

  Fly   149 VPSTAVTQPNDIVASSSHNKSSTGR--SSFWERRK----VWNIDELLAETESIQPQAARNIVKLF 207
            :...|...|. |....|.:....|:  |||  .||    |..|.|.|.        ..||  :.|
Mouse   320 IYRNAFATPT-ISLQDSCDYLDRGQPTSSF--SRKGPSTVQKIKEALG--------FMRN--QHF 371

  Fly   208 EDENTIPFICRYRRDLVDHIAPD-RLRDIRNTY---TEIVDLRKRAENI------IGKLQRENI- 261
            |    :|||..||::.|:   |: .:.|:...:   .:...||.|.||:      :...|.|.|
Mouse   372 E----VPFIAFYRKEYVE---PELHINDLWRVWQWDEKWTQLRIRKENLTRLFEKMQAYQYEQIS 429

  Fly   262 ------MTPEIR-------EELMCAKSNEELEFLYAPY--------------------------- 286
                  :...||       |.|...:|.:||:.:|..:
Mouse   430 ADPDKPLADGIRALDTTDMERLKDVQSMDELKDVYNHFLLYYGRDIPKMQNAAKASRKKLKRIKE 494

  Fly   287 ---------------------KPASKGTLAERAKALGLQVYADCLLYGSAPK---VNLSEIVDR- 326
                                 |.||:..:....::.||...|.  .:|..|:   .||.:...|
Mouse   495 DGDEEGEGEEAEDEEQRGPELKQASRRDMYTICQSAGLDGLAK--KFGLTPEQFGENLRDSYQRH 557

  Fly   327 RNEALATEAL----------------VMSGICQIIIHNISKNTNVLEEIRRLQNVHRVFLKCSKT 375
            ..|....|.|                |:.|...::...|::...|.:.:|:... .|..|..:.|
Mouse   558 ETEQFPAEPLELAKDYVCSQFPTPEAVLEGARYMVALQIAREPLVRQVLRQTFQ-ERAKLNITPT 621

  Fly   376 KEAKSSKSSSSSKASSSKGSNQNADKKLDSSKFENYFNF--QGDVKTIKPYQMLAINRGEKHKWL 438
            |:.:                     |.:|.:.:...|.:  ...||.::..|.|.|...|....|
Mouse   622 KKGR---------------------KDVDEAHYAYSFKYLKNKPVKELRDDQFLKIGLAEDEGLL 665

  Fly   439 SVKIET---------ND--YLKRDLMRYITDQYMNQGLQYPLRREVFTKSLEECYAKKLQPLMCR 492
            ::.|..         ||  |.:.....|..|::.:|..::..:|   |.::|....:.|...|.:
Mouse   666 TIDISIDMKGVEGYGNDQTYFEEIKQFYYRDEFSHQVQEWNRQR---TMAIERALQQFLYVQMAK 727

  Fly   493 QIRAALKEKGTKAAIDVFAKNLKQLLLISPL------------------KGERILGI-------D 532
            :::..|..:..::.:...::.|...|.::|.                  ||.|:|||       .
Mouse   728 ELKNKLLAEARESVVKACSRKLYNWLRVAPYRPDQQVEEDDDFMDENQGKGIRVLGIAFSSARDH 792

  Fly   533 PGF---INGCKLALISETADVLYTGVIYPHGA------------------------MSNKR---- 566
            |.|   :||     ..|..|.|.    .||..                        :.||:
Mouse   793 PVFCALVNG-----EGEVTDFLR----LPHFTKRRTAWREEEREKKAQDIETLKKFLVNKKPHVV 848

  Fly   567 --AAEQKLVQLLSDHNCKIIGLGNGTACRETEHWLTGMFHAGVLDSRIIRYSIVNENGASIYSCS 629
              |.|.:..|:|::...:|:            |.|.   ....|.|  |...:|:...|.:|..|
Mouse   849 TIAGENRDAQMLTEDVKRIV------------HELD---QGQQLSS--IGVELVDNELAILYMNS 896

  Fly   630 NVAAKEFPKMDTNERSAVSIARRLNDPLSEY------------VKIEPRHLGVGMYQHDVPEKIL 682
            ..:..||.......|.|||:|||:.|||.|:            :|..|      :.:|.|.|::|
Mouse   897 KKSEAEFRDYPPVLRQAVSLARRIQDPLIEFAQVCSSDEDILCLKFHP------LQEHVVKEELL 955

  Fly   683 TASLNDVVSECVSYVGVDLNTA-----SLSVLKHIAGLSEKKAEKIIEHRTQKGP-FKTRKDLLS 741
            .|...:.::. |:.||||:|.|     |.::::::.||..:|...:::...|... .::|..|::
Mouse   956 NALYCEFINR-VNEVGVDVNRAIAHPYSQALIQYVCGLGPRKGTHLLKILKQNNTRLESRTQLVT 1019

  Fly   742 VRSIGEKSFVQCAGFVRIEPRSVGGQLQN---PLDCTWVHPESYN-----VVESIVGECDLKLSD 798
            :..:|.|.|:.||||::|:..|:|....:   .||.:.||||:|.     .|:::  |.|....|
Mouse  1020 MCHMGPKVFMNCAGFLKIDTASLGDSTDSYIEVLDGSRVHPETYEWARKMAVDAL--EYDESAED 1082

  Fly   799 VGKAAFIASIKQFASSQPNLDRIAKQHKLPMERLEFLLVALQRE-------LLQDYRADL----- 851
            ...|..:..|.:......:||            |:.....|:|:       .|.|.||:|
Mouse  1083 ANPAGALEEILENPERLKDLD------------LDAFAEELERQGYGDKHITLYDIRAELSCRYK 1135

  Fly   852 DKRPLFKQGLTR----------LDDLSMGEVVTGAVTNVT----------------QFGAF---- 886
            |.|..::...|.          .:...:|:::...||.:.                :.|.:
Mouse  1136 DLRTAYRSPNTEEIFNMLTKETPETFYIGKLIICNVTGIAHRRPQGESYDQAIRNDETGLWQCPF 1200

  Fly   887 -------------------------------VDVGVERNGLIHNSNMNN-------SQLSVGDRI 913
                                           :|.||  .|.|....:::       .::.||..:
Mouse  1201 CQQDNFPELSEVWNHFDSGSCPGQAIGVKTRLDNGV--TGFIPTKFLSDKVVKRPEERVKVGMTV 1263

  Fly   914 VASVVKVDLKRRQLEL--RLENML-------METDTSFKFKAE 947
            ...::|:|:::...:|  |..:::       :..||.:.|.||
Mouse  1264 HCRIMKIDIEKFSADLTCRTSDLMDRNNEWKLPKDTYYDFDAE 1306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31156	NP_651070.3	Tex	184..931	CDD:225094	195/1017 (19%)
		Tex_N	190..362	CDD:286460	47/263 (18%)
		Tex_YqgF	527..653	CDD:293526	37/165 (22%)
		HHH_3	697..758	CDD:289597	20/66 (30%)
		S1_like	870..930	CDD:299122	14/119 (12%)
Supt6	NP_033323.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..197
		Interaction with PAAF1. /evidence=ECO:0000250	2..916		156/798 (20%)
		Interaction with IWS1	2..485		71/314 (23%)
		Interaction with KDM6A. /evidence=ECO:0000269\|PubMed:23503590	317..1300		209/1078 (19%)
		HTH_44	<348..422	CDD:291314	24/92 (26%)
		Tex	372..1353	CDD:225094	195/1018 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..520		2/30 (7%)
		Tex_N	<565..623	CDD:286460	10/58 (17%)
		YqgF	775..931	CDD:258777	44/181 (24%)
		HHH_7	935..1038	CDD:291309	28/109 (26%)
		DLD	1053..1157	CDD:291540	26/117 (22%)
		S1	<1227..1282	CDD:197648	10/56 (18%)
		SH2_2	1304..1514	CDD:291307	2/3 (67%)
		SH2_Nterm_SPT6_like	1331..1415	CDD:198174
		SH2_Cterm_SPT6_like	1424..1515	CDD:198182
		Interaction with histone H2B and H3. /evidence=ECO:0000250	1633..1726
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1636..1726
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2183
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810