DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31156 and ZK973.1

DIOPT Version :9

Sequence 1:	NP_651070.3	Gene:	CG31156 / 42669	FlyBaseID:	FBgn0051156	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_491362.1	Gene:	ZK973.1 / 172040	WormBaseID:	WBGene00022830	Length:	745	Species:	Caenorhabditis elegans

Alignment Length:	799	Identity:	216/799 - (27%)
Similarity:	374/799 - (46%)	Gaps:	158/799 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 ETESIQPQAARNIVKLFEDENTIPFICRYRRDLVDHIAPDRLRDIRNTYTEIVDLRKRAENIIGK 255
            |...:....|:.:|.||::.....:|.|||.|:..::||:::|.....|.:..:|..:..:.|..
Worm    24 EVHELNSTQAQRLVSLFKNGCETAYIARYRGDVHGYLAPEKIRKAMEAYVDAKNLNNKVSSAIST 88

  Fly   256 L-------QRENIMTPEIR--EELMCAKSNEELEFLYAPYKPASKGTLAERAKALGLQVYADCLL 311
            :       |.:.|:|...:  ||.      :|:..:...|...::.|.|..|:||||:..|..:|
Worm    89 VTAKVAGAQEKIIVTERFKRCEEF------DEVTDISKEYSTGTRKTKANIARALGLEPPAQSIL 147

  Fly   312 YGSAP--------------------KVNLSEIVDRRNEALATEALVMSGICQIIIHNISKNTNVL 356
            .|:..                    |:.|:::::|..|                :..:|.|.::|
Worm   148 DGNFVDFKSLLSNGLKTVKDVEEHLKICLADLINRDEE----------------VRKVSANIDIL 196

  Fly   357 EEIRRLQNVHRVFLKCSKTKEAKSSKSSSSSKASSSKGSNQNADKKLDSSKFENYFNFQGDVKTI 421
            ::..|:              .||.|:.:..::        ::.:|:....|::|:...:.:.:.|
Worm   197 KKECRV--------------SAKLSREAEKNR--------KDLEKRGIIEKYKNFIGEKWNAEDI 239

  Fly   422 KPYQMLAINRGEKHKWLSVKIET--NDYLKRDLMRYITDQYMNQGLQYPLRREVFTKSLEECYAK 484
            :.:.:.|:|:|.....::.|||.  ||      .:||          :|..|:.....::..|.:
Worm   240 RDHTVSALNKGFDEGIITWKIECEFND------AKYI----------HPFSRKSVYFGMKNFYQE 288

  Fly   485 KLQ--------PLMCRQIRAALKEKGTKAAIDVFAKNLKQLLLISPLKGERILGIDPGFINGCKL 541
            .|.        |.:.|::...||:|....:|.:|.:|:.|||....::.:.::.:||| .:..|.
Worm   289 ALAYSIKNYFIPRIERKMANHLKDKAKDRSIVLFGENVDQLLSQEGIRDKFVIALDPG-RSKIKT 352

  Fly   542 ALISETADV-------LYTGVIYPHGAMSNKRAAEQKLVQLLSDHNCKIIGLGNGTACRETEHWL 599
            |.:..|.:|       :| |..:..|.:...:...|:     ::....:..:||||....|:..:
Worm   353 AFLKPTGEVVDMSSFSIY-GTRFDGGGVDLLKKWSQQ-----TERKDIVFAIGNGTNTYNTQIAV 411

  Fly   600 TGMFHAGVLDSRI-IRYSIVNENGASIYSCSNVAAKEF-PKMDTNERSAVSIARRLNDPLSEYVK 662
            :.|.::.|....| :.|.||.|:|||.|||:..|.:|| ...:..|.|||||.|||.||:|||||
Worm   412 SDMINSNVFPKEINVSYCIVPEHGASKYSCTPSAIEEFGENAEITEISAVSIGRRLIDPMSEYVK 476

  Fly   663 IEPRHLGVGMYQHDVPEKILTASLNDVVSECVSYVGVDLNTASLSVLKHIAGLSEKKAEKIIEHR 727
            |||:|||.|.||..|..|.|..||.:||.:.||:.||||||||.::|:.|.||:||.|::|:::|
Worm   477 IEPQHLGKGQYQLSVDPKKLNESLLNVVRDRVSFNGVDLNTASKNLLQRINGLNEKTAKEIVQYR 541

  Fly   728 TQKGPFKTRKDLLSVRSIGEKSFVQCAGFVRIE--------------PRSVGGQLQNPLDCTWVH 778
            .|.|.|::|.:|..|:.||..:|.|||||:.:.              .:|...:..||.|.|.||
Worm   542 EQNGRFRSRAELKEVKGIGALTFQQCAGFLTVSRPDDAEDGPPKKKFKKSSTSKEWNPFDETIVH 606

  Fly   779 PESYNVVESIVGECDLKLSDVGKAAFIASIKQFASSQPNLDRIAKQHKLPMERLEFLLVALQREL 843
            |:.|...||::|:.::.:.|:     ...||.|:.|           :|..|..:.|      .|
Worm   607 PDDYRTGESLLGKLNVSIEDI-----TGRIKSFSIS-----------RLTAEEAKVL------NL 649

  Fly   844 LQD--YRADLDKRPLFKQGLTRLDDLSMGEVVTGAVTNVTQFGAFVDVGVERNGLIHNSNMNNSQ 906
            ||:  .:..:...|..:..:.::.||:.|:..||.|:|.|.||.|:|:||.::||.|.|:..:..
Worm   650 LQNLTLKTKMKPPPPLRTKVGQIRDLAEGQRFTGTVSNKTDFGVFIDIGVGQDGLAHISHFKDGH 714

  Fly   907 L-----SVGDRIVASVVKV 920
            .     ||.|.:...:.|:
Worm   715 YSLMLPSVNDSVEVVIDKI 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31156	NP_651070.3	Tex	184..931	CDD:225094	216/799 (27%)
		Tex_N	190..362	CDD:286460	40/199 (20%)
		Tex_YqgF	527..653	CDD:293526	39/134 (29%)
		HHH_3	697..758	CDD:289597	31/60 (52%)
		S1_like	870..930	CDD:299122	20/56 (36%)
ZK973.1	NP_491362.1	Tex	27..742	CDD:225094	215/796 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164769
Domainoid	1	1.000	69	1.000	Domainoid score	I6327
eggNOG	1	0.900	-	-		E1_COG2183
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9994
Inparanoid	1	1.050	258	1.000	Inparanoid score	I1932
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62824
OrthoDB	1	1.010	-	-		D321814at33208
OrthoFinder	1	1.000	-	-		FOG0006115
OrthoInspector	1	1.000	-	-		oto19025
orthoMCL	1	0.900	-	-		OOG6_104871
Panther	1	1.100	-	-	LDO	PTHR10724
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4297
SonicParanoid	1	1.000	-	-		X5053
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800