DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31156 and srbd1

DIOPT Version :9

Sequence 1:	NP_651070.3	Gene:	CG31156 / 42669	FlyBaseID:	FBgn0051156	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	XP_021336424.1	Gene:	srbd1 / 100320270	ZFINID:	ZDB-GENE-081107-19	Length:	982	Species:	Danio rerio

Alignment Length:	1030	Identity:	341/1030 - (33%)
Similarity:	528/1030 - (51%)	Gaps:	144/1030 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKRPRRAASTKKIVIEISDSDEEV---NLTADDDYRPEE------------TKSRIIDRAADAQ 50
            |.:|||   :|.|:..|.:..||:.   ::||:..|..||            .|...:.:..|..
Zfish     1 MLRRPR---TTAKVYTEPTTDDEDEDFDDMTANQKYDSEELDEWLPKLKEGKAKEGKVQKGTDGS 62

  Fly    51 T---VVTKRQRFPTSKKTAAEGP--APKKKRGDKEKADENACPN-ENNPESVVQDTPSTSNQRNG 109
            |   ..|||...|...|..||..  ||:..:..|||      || |...|.:|...|    :::.
Zfish    63 TEKKKATKRVAKPKEPKPKAERKPRAPRVPKAKKEK------PNTEQQNEDMVLLKP----EQDV 117

  Fly   110 AVGTEH------NSEAPAPKRKRARKDKEDLKTAANETNPEKGDVVPSTAVTQPNDIVASSSHNK 168
            .:..|.      :|..|.|      :|.:|:        |.:|   ||:  :||...|.....|.
Zfish   118 KIKEERLSMNLSSSNVPVP------RDNDDV--------PGEG---PSS--SQPFFKVKKEEPND 163

  Fly   169 SSTGRSSFWERRKV------------------------WNIDELLAETESIQPQAARNIVKLFED 209
            |.|......:::|.                        |:...:|||...:......||.:|.|:
Zfish   164 SFTFEEPVQKKQKTSDAAQGRPIKLKSTGSVLEDLQMNWDPIRVLAEKAGVAQWVCMNIAQLLEE 228

  Fly   210 ENTIPFICRYRRDLVDHIAPDRLRDIRNTYTEIVDLRKRAENIIGKLQRENIMTPEIREELMCAK 274
            ||||||:.|||::|::|:..|.:||::.|..|:..:.|::.::...|::|.::|.|:...|....
Zfish   229 ENTIPFMVRYRKELINHMDADAVRDVQQTLDELRSVAKKSRSVAQTLKKEGVLTSELEMALKNCT 293

  Fly   275 SNEELEFLYAPYKPASKGTLAERAKALGLQVYADCLLYGSAPKVNLSEIVDRRNEALATEALVMS 339
            :.:|:|.:|||||..||.:.|.|||.|||:..|..||: |...:||...:....:.|::...|.:
Zfish   294 TADEIEHVYAPYKKGSKLSKARRAKELGLEPVALALLH-SPQTLNLHASIQPNTKGLSSLDEVAT 357

  Fly   340 GICQIIIHNISKNTNVLEEIRRLQNVHRVFLKCSKTKEAKSSKSSSSSKASSSKGSNQNADKK-- 402
            |:.:|:.:.|:|:...|..::.|         |.:   :..:..|:.||.:..:..:|.||:|
Zfish   358 GVQEILAYMIAKDKETLTYVQSL---------CDR---SAVTIHSAVSKTALKEQQSQQADQKSK 410

  Fly   403 -LDSSKFENYFNFQGDVKTIKPYQMLAINRGEKHKWLSVKIETNDYLKRDLMRY-ITDQYMNQGL 465
             .|.:||..|.:|..||:.|:.:|.|||||||..|.|:||:...|::|.|..|: :..::..:|.
Zfish   411 PKDIAKFSLYTDFTCDVQRIQHHQTLAINRGENLKILTVKVNIPDWVKNDFCRWCVNVRWRPKGF 475

  Fly   466 QYPLRREVFTKSLEECYAKKLQPLMCRQIRAALKEKGTKAAIDVFAKNLKQLLLISPLKGERILG 530
            ..|....:...:.|:.|.:.:.|.:.|..|..|.....|.:|.:|.:||:|.||:.|::|..|:|
Zfish   476 AQPELMSILKNAAEDSYKRLILPFLNRGYRTKLTASAEKESIAMFVRNLRQRLLMCPVRGRVIMG 540

  Fly   531 IDPGFINGCKLALISETADVLYTGVIYPHGAMSNKRAAEQKLVQLLSDHNCKIIGLGNGTACRET 595
            :||||.:|||||::|.|:.:::|.|:|.||....:.|  .||.||:..::|:.|.:|||.|||||
Zfish   541 VDPGFYHGCKLAILSPTSQIVHTDVVYLHGPAIEREA--DKLRQLMFKYSCQTIVIGNGKACRET 603

  Fly   596 EHWLTGMFHAGVLDSRIIRYSIVNENGASIYSCSNVAAKEFPKMDTNERSAVSIARRLNDPLSEY 660
            |.:...:..........:.|.|.:|.||||||.|..|.||.|.||.|.||||||.||:.|||:|.
Zfish   604 EAFFADLIKQRFFSPMDVSYCITDEAGASIYSVSPEAVKEMPDMDPNLRSAVSIGRRVQDPLAEL 668

  Fly   661 VKIEPRHLGVGMYQHDVPEKILTASLNDVVSECVSYVGVDLNTASLSVLKHIAGLSEKKAEKIIE 725
            :||:|:|:|:|.|||||.:.:|.|:|:.||.||||:||||:|..|.::::|||||:..:|..|:|
Zfish   669 IKIDPKHIGIGTYQHDVSQSLLRAALDGVVQECVSFVGVDINICSETLMRHIAGLNAGRARSIME 733

  Fly   726 HRTQKGPFKTRKDLLSVRSIGEKSFVQCAGFVRIEP---RSVGG---------QLQ--------- 769
            .:.:.|||..|..|..|:.:|.|||.|||||:||.|   ||:|.         |.|
Zfish   734 WKEKNGPFFNRDQLKLVKGLGPKSFQQCAGFIRINPETVRSIGSGGKEDPEIPQKQTAEKKKVKG 798

  Fly   770 --------NPLDCTWVHPESYNVVESIVGECDLKLSDVGKAAFIASIKQFASSQPNLDRIAKQHK 826
                    ||||.|.:|||||::....:.:....|..:|.:|...||:....|. .||.:||...
Zfish   799 SASISNDFNPLDQTCIHPESYSIALRFLTQIAGSLDQMGSSALRQSIESSVRSS-GLDVLAKSLN 862

  Fly   827 LPMERLEFLLVALQRELLQDYRADLDKRPLFKQGLTRLDDLSMGEVVTGAVTNVTQFGAFVDVGV 891
            ...|.|:.::..|.:....|.|.:.::.. ||:.:..::||..|.|:||.|||...||||||:||
Zfish   863 TTPETLQLIVDGLTQPPGFDIRQNFEQAD-FKREVVSMNDLHDGMVLTGRVTNTALFGAFVDIGV 926

  Fly   892 ERNGLIHNSNMNNSQLSV-----------GDRIVASVVKVDLKRRQLELRLENML 935
            .|:|||....:...:|.|           |:|:...|:.||::|.::.|.|..:|
Zfish   927 GRSGLIPKRFITPEKLPVDQRRRSLALGPGERVEVRVMNVDIQRNRITLDLIRVL 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31156	NP_651070.3	Tex	184..931	CDD:225094	286/790 (36%)
		Tex_N	190..362	CDD:286460	57/171 (33%)
		Tex_YqgF	527..653	CDD:293526	58/125 (46%)
		HHH_3	697..758	CDD:289597	29/60 (48%)
		S1_like	870..930	CDD:299122	27/70 (39%)
srbd1	XP_021336424.1	FinO_conjug_rep	<45..120	CDD:326555	21/84 (25%)
srbd1	XP_021336424.1	Pnp	199..977	CDD:333075	287/794 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592531
Domainoid	1	1.000	115	1.000	Domainoid score	I5988
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	434	1.000	Inparanoid score	I1669
OMA	1	1.010	-	-		QHG62824
OrthoDB	1	1.010	-	-		D321814at33208
OrthoFinder	1	1.000	-	-		FOG0006115
OrthoInspector	1	1.000	-	-		oto40098
orthoMCL	1	0.900	-	-		OOG6_104871
Panther	1	1.100	-	-	LDO	PTHR10724
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4297
SonicParanoid	1	1.000	-	-		X5053
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940