Protein Alignment Efa6 and SEC7

DIOPT Version :10

• Sequence 1: NP_001163691.2
• Gene: Efa6 / 42665
• FlyBaseID: FBgn0051158
• Length: 1601
• Species: Drosophila melanogaster
• Sequence 2: NP_010454.3
• Gene: SEC7 / 851748
• SGDID: S000002577
• Length: 2009
• Species: Saccharomyces cerevisiae
• Alignment Length: 1190
• Identity: 223/1190 - (18%)
• Similarity: 401/1190 - (33%)
• Gaps: 416/1190 - (34%)

  Fly   375 APRASGE-SSPTSSSSVDSPTNTSSDSVKREAKLLQKQQQQ---QQQTYQQQQQRDSINNSYN-- 433
            |.:..|| ||...::|..:|:....:::|.|||....:.|:   .:......:.:::.|::.|
Yeast    10 AEKGDGEISSNVETASSVNPSVKPQNAIKEEAKETNGEDQKCKGPENAGSTAETKETSNDATNGM 74

  Fly   434 RKDSLTNDTLLMCEELEPDEEGEYVLEEDNKQQRQRQQQQRYRQQQNQQRYEYYQNEDELEEQEE 498
            :....|.||    .:...|:||     ||.                         :|||.|:::|
Yeast    75 KTPEETEDT----NDKRHDDEG-----EDG-------------------------DEDEDEDEDE 105

  Fly   499 VEEEREEDQTHYDITNIETYQSGVGRGDDDDSDRQCLVDDDDDDDAYDDEENDAGDEDYSTNSLG 563
            .|:..:||....|.::.||       ..:|..|.:.:..:..:..:.:|||:|..|.:.|.:|.|
Yeast   106 DEDNGDEDDEDVDSSSSET-------SSEDGEDSESVSGESTESSSGEDEESDESDGNTSNSSSG 163

  Fly   564 --SGSAKQRLRALKQRTATRQQQRN--------RDAVDCAGRSGSGSSST-TVKSEAGGLGLDET 617
              |||.::     ::.....:::.|        :|:|.....:...|:.| .:...:.|...:.|
Yeast   164 DESGSEEE-----EEEEEEEEEEENAGEPAIAHQDSVPTNDSTAPRSTHTRNISLSSNGSNTNST 223

  Fly   618 SFSVPTSPISLSTPLIDKETANSVPTSPEPSSLVPESSSGAGAGAVVVRR---------HNGH-- 671
            ...|.|   :|.|.|.||:              :.::|:...|....:::         :|.|
Yeast   224 IILVKT---TLETILNDKD--------------IKKNSNAQKAIERTLQKFKEFDPQTTNNPHYV 271

  Fly   672 ---VVRKCDAAGFRTSKSE------DHLQQI----------------------QREGIA-AVIPI 704
               :|.:...|..||..|:      |.|.::                      ||:..| .:.|.
Yeast   272 DSILVFEALRASCRTKSSKVQSLALDCLSKLFSFRSLDETLLVNPPDSLASNDQRQDAADGITPP 336

  Fly   705 DIDEDVNSSLNTLLDTRQD--------------------SEDSQSM--------ATVIVNNSSLA 741
            ...:.::::::|:.|..|.                    .|||.|:        |...:.|..:.
Yeast   337 PKQKIIDAAIDTISDCFQGEGTDDRVELQIVRALSSCILEEDSSSLCHGASLLKAIRTIYNVFVF 401

  Fly   742 SNN--NEG--------------EQTDNRSSSSSSNSSDNNN-----------CSSNTGEPA---- 775
            |.|  |:|              ::.|.:.|:||:.|....|           .|.|...||
Yeast   402 SLNPSNQGIAQATLTQIISSVYDKIDLKQSTSSAVSLSTKNHQQQSAIELSEASENAETPAPLTL 466

  Fly   776 -------------------------TSETATATATII-------------TATSTRTMNCSSKL- 801
                                     ..:.|...|.::             |....|:....|||
Yeast   467 ENMDKLNDDEERLMDAQQPDSIAITNQDLAVKDAFLVFRVMAKICAKPLETELDMRSHAVRSKLL 531

  Fly   802 -------------------NYIL------CKKASDRD--RIVWTYNA--PLQP------------ 825
                               |..|      |...|.|.  |:|.:.||  ||.|
Yeast   532 SLHIIYSIIKDHIDVFLSHNIFLPGKERVCFIDSIRQYLRLVLSRNAASPLAPVFEVTLEIMWLL 596

  Fly   826 --------------------HQLAALQRQQQQQEQQFQQQQQQLHQQ---------------HLQ 855
                                ..::.|.....||::.|....|::...               .:.
Yeast   597 IANLRADFVKEIPVFLTEIYFPISELTTSTSQQKRYFLSVIQRICNDPRTLVEFYLNYDCNPGMP 661

  Fly   856 QQQQLQQQHQQQ---QQQQQQQQQQQLYGQQSHSNSHSSSISSSPQHSAVGSPASPTSVSSSVMS 917
            ...::...:..:   .:.:..|.|:..|.:|...:..:.:.|..|            .::||.:|
Yeast   662 NVMEITVDYLTRLALTRVEITQTQRSYYDEQISKSLSTYNFSQLP------------LLTSSNLS 714

  Fly   918 SSGSKGALGLGSSSNGPMAAVQ----QQQLREREQGGQVAQPPSGIPGLLSCPGGGCGNNGGGGG 978
            ||...|.:.|....:..:..|.    ...||........|..|
Yeast   715 SSPDVGQVNLLFPLDFALKMVSLNCIVSVLRSLSSWAHKALNP---------------------- 757

  Fly   979 IGGGGNNDQSVSEAISNISSPDYQDDDNLLSSRDILGGMVLSD----PSDSDSTILVSDAAAHQR 1039
                  |..:.::.:.|.:|...|:..:.||: |:...::.|:    |:..|.         ..|
Yeast   758 ------NTHTANKVLLNTTSSARQESRSSLSN-DVRSSIMTSNDDFKPTYEDE---------ESR 806

  Fly  1040 QQLKQQLRAQQQQQRERERDRDRDREQSEHKVVIQVRGLDSNSSGGNGTNGRSEEDVVTLTDEPL 1104
            ....|.:.|....|.|..:.|         |..:                   .|.:....::|.
Yeast   807 SLSSQNIDADDPTQFENLKLR---------KTAL-------------------SECIAIFNNKPK 843

  Fly  1105 GTMTVGMRDASPPVSDDGSDVESLHSYHYSPKAVDMPSAIRLAKRLHSLDGFKKSDVSRHLSKNN 1169
            ..:.|.::...  :.||                    |.|.:||.|...:|...:.|..:|.:.:
Yeast   844 KAIPVLIKKGF--LKDD--------------------SPISIAKWLLETEGLDMAAVGDYLGEGD 886

  Fly  1170 DFSRAVADEYLKHFTFEKKSLDQALREFLQQFSLSGETQERERVLVHFSKRFLDCNPGTFNSQDA 1234
            |.:.|:...::..|.|...|:..|||.|||.|.|.||.|:.:|.::.|::||:|.|||.|:..|.
Yeast   887 DKNIAIMHAFVDEFDFTGMSIVDALRSFLQSFRLPGEGQKIDRFMLKFAERFVDQNPGVFSKADT 951

  Fly  1235 VHTLTCAIMLLNTDLHGQNINRKMSCAEFVDNLADLNDGENFPKDVLKSLYQAIKTKPLEWALDE 1299
            .:.|:.::::||||||...|..|||..||::|...:::|.:.|:|.|:.|:..|....::...::
Yeast   952 AYVLSYSLIMLNTDLHSSQIKNKMSLQEFLENNEGIDNGRDLPRDFLEGLFNEIANNEIKLISEQ 1016

  Fly  1300 E----AGDL----QQQRANN 1311
            .    :||.    |||.|.|
Yeast  1017 HQAMLSGDTNLVQQQQSAFN 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Efa6	NP_001163691.2	PDZ_canonical	6..85	CDD:467153
		PHA03269	225..>344	CDD:165527
		Sec7	1124..1293	CDD:238100	54/168 (32%)
		PH_EFA6	1330..1452	CDD:270107
SEC7	NP_010454.3	PLN03076	272..1935	CDD:215560	159/865 (18%)