Protein Alignment Efa6 and Psd2

DIOPT Version :10

• Sequence 1: NP_001163691.2
• Gene: Efa6 / 42665
• FlyBaseID: FBgn0051158
• Length: 1601
• Species: Drosophila melanogaster
• Sequence 2: XP_038952793.1
• Gene: Psd2 / 307500
• RGDID: 1311075
• Length: 772
• Species: Rattus norvegicus
• Alignment Length: 945
• Identity: 288/945 - (30%)
• Similarity: 408/945 - (43%)
• Gaps: 254/945 - (26%)

  Fly   649 SLVPESSSGAGAGAVVVRRHNGHVVRKCDAAGFRTSKSEDHLQQIQREGIAAVIPIDIDEDVNSS 713
            ||.||...|...|.......|.||:   .....:|...|..::.:....:|  :|     .::.|
  Rat    21 SLEPEEGPGVQNGTAASESLNSHVI---SPVSEKTGTLEGTMEPVGNPDVA--LP-----GLSLS 75

  Fly   714 LNTLLDTRQDS---EDSQSMATVIVNNSSLASNNNEGEQTDNRSSSSSSNSSDNNNCSSNTGEPA 775
            |...|...||.   |||      :.:....||...|.|.|.......:.::....:|   .|||.
  Rat    76 LTNGLALGQDGNILEDS------VESRPWRASGPAEEEDTPRSLCLDAEDTQLGLDC---PGEPD 131

  Fly   776 TSETATAT-ATIITATSTRTMNCSSKLNYILCKKASDRDRIVWTYNAPLQPHQLAALQRQQQQQE 839
            ..:..:|| ..|:.:...|....||..:..:.....:.|..| ::.|||.|
  Rat   132 VRDGFSATFEKILESELLRGTQYSSLDSLDVLSLTDESDSCV-SFEAPLTP-------------- 181

  Fly   840 QQFQQQQQQLHQQHLQQQQQLQQQHQQQQQQQQQQQQQQLYGQQSHSNSHSSSISSSPQHSAVGS 904
                                |.||..:                            .||:.:.:|
  Rat   182 --------------------LIQQRAR----------------------------DSPEPAGLG- 197

  Fly   905 PASPTSVSSSVMSSSGSKGALGLGSSSNGPMAAVQQQQLREREQGGQVAQPPSGIPGLLSCPGGG 969
                       :...|.:|.||.....:|.:.:..::.:........::.     ..|.|.|.|
  Rat   198 -----------IGDIGPEGDLGAAGGGDGELGSPLRRSISSSRSENVLSH-----LSLTSMPNG- 245

  Fly   970 CGNNGGGGGIGGGGNNDQSVSEAISNISSPDYQDDDNLLSSRDILGGMVLSDPSDSDSTILVSDA 1034
             .:....||.||...:|:...:.:::.|....:|            |:     |||||.:..|:
  Rat   246 -FHEDEPGGSGGDDEDDEDTDKVLNSASDTSLKD------------GL-----SDSDSELSSSE- 291

  Fly  1035 AAHQRQQLKQQLRAQQQQQRERERDRDRDREQSEHKVVIQVRGLDSNSSG--GNGTNGRSEEDVV 1097
                                                      ||:..|:.  .||..|.||
  Rat   292 ------------------------------------------GLEPGSTDPMANGCQGVSE---- 310

  Fly  1098 TLTDEPLGTMTVGMRDASPPVSDDGSDVESLHSYHYSPKAVDMPSAIRLAKRLHSLDGFKKSDVS 1162
                                                        :|.|||:||:.|:||::.||:
  Rat   311 --------------------------------------------AARRLARRLYHLEGFQRCDVA 331

  Fly  1163 RHLSKNNDFSRAVADEYLKHFTFEKKSLDQALREFLQQFSLSGETQERERVLVHFSKRFLDCNPG 1227
            |.|.|||:|||.||.|||..|.|...:||:|||.||:.|.|.||||||||||.|||:|:..|||.
  Rat   332 RQLGKNNEFSRLVAGEYLSFFDFSGLTLDRALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPD 396

  Fly  1228 TFNSQDAVHTLTCAIMLLNTDLHGQ-NINRKMSCAEFVDNLADLNDGENFPKDVLKSLYQAIKTK 1291
            ...|:|.:||||||:|||||||||. ||.:||||.:|:.||..||||::|.||:||:||.:||.:
  Rat   397 DSTSEDGIHTLTCALMLLNTDLHGHVNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNE 461

  Fly  1292 PLEWALDEEAGDLQQQRANNSALGN--------------VGLNPFLDPPELATAVEYKKGYVMRK 1342
            .||||:||:     :.|.:.|.|.:              .|.|||||.|:..:|..||.|.:.||
  Rat   462 KLEWAIDED-----ELRKSLSELVDDKFGTGTKKVTRILDGGNPFLDVPQALSATTYKHGVLTRK 521

  Fly  1343 CCYDSSFKKTPFGKRSWKMFYCTLRDLVLYLHKDEHGFRKSQMSDNLHNAIRIHHALATKANDYT 1407
            ...|...|:||.|:|.||.||..|:..:|||.|||:...|:....:|.||||:||||||:|:||:
  Rat   522 THADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATRASDYS 586

  Fly  1408 KKQHVFRLQTADQAEYLFQTSDSKELQSWVETINYVCAAISAPPLEGGVGSQKRFQRPLLPSKQS 1472
            ||.:|.:|:|||...:|||....:|:.||:..||.|.|..|||.....|.|.|:|.||||||..:
  Rat   587 KKSNVLKLKTADWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTT 651

  Fly  1473 KLMLKEQLDSHEVQLAQLDQELNEHKKGPIPSKGL---ALQNYKEKESYLQYELRRYRTYVSILS 1534
            :...:|||.|||.:|.|:..||.||:..|: .:||   ..:.|:.||.||.:|..||.||:.:|:
  Rat   652 RFCQEEQLRSHENKLRQVTAELAEHRCHPL-ERGLKSKEAEEYRLKEHYLTFEKSRYETYIHLLA 715

  Fly  1535 AKMLADQQQLE--------LQAQQP-------SPA 1554
            .|:......||        |:.:.|       |||
  Rat   716 VKIKVGSDDLERIEARLATLEGEDPALRKTHSSPA 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Efa6	NP_001163691.2	PDZ_canonical	6..85	CDD:467153
		PHA03269	225..>344	CDD:165527
		Sec7	1124..1293	CDD:238100	91/169 (54%)
		PH_EFA6	1330..1452	CDD:270107	58/121 (48%)
Psd2	XP_038952793.1	Sec7	295..463	CDD:238100	97/215 (45%)
		PH_EFA6	509..632	CDD:270107	58/122 (48%)