Protein Alignment Efa6 and spo7

DIOPT Version :10

• Sequence 1: NP_001163691.2
• Gene: Efa6 / 42665
• FlyBaseID: FBgn0051158
• Length: 1601
• Species: Drosophila melanogaster
• Sequence 2: NP_594113.1
• Gene: spo7 / 2541456
• PomBaseID: SPAC6G9.04
• Length: 1318
• Species: Schizosaccharomyces pombe
• Alignment Length: 1553
• Identity: 255/1553 - (16%)
• Similarity: 444/1553 - (28%)
• Gaps: 656/1553 - (42%)

  Fly   377 RASGESSPTSSSSVDSPTNTSSDSVKREAKLLQKQQQQQQQTYQQQQQRDSINNSYNRKDSLTND 441
            |.:..|||||.|..:......|.:   ::::..:..::.:.||...|:..::.:...| ..:|.|
pombe     4 RITEGSSPTSLSVSEKIAKLESCN---DSRITCRPVRESKPTYTSGQKHSALLSKLKR-SKVTTD 64

  Fly   442 TL-------LMCEELEPDEEGEYVLEEDNKQQRQRQQQQRYRQQQ---NQQRYEYYQNEDELEEQ 496
            ..       ::|:|....|..:...|..:.:.:..|::.|.:|.|   :.:|.....|.:.:|.:
pombe    65 FCKLEESKGIICQENLHTEGAKSKTENISGEDKSSQRRTRLKQIQEFISHRRSFLNSNANSVESE 129

  Fly   497 EEVEEEREEDQTHYDITNIETY--------------------------------QSGVGRGDDDD 529
            :.:.|..........::|.|::                                ||..|.|....
pombe   130 KILAENNHMFNVKSKLSNKESFIKTRRPRTNGELSDLSLQPKRIFSEPVNSHPSQSMFGNGVRAS 194

  Fly   530 SDRQCLVDDDDDDDAYDDE---------------ENDAGDEDYSTNSLGSGSAKQRLR------- 572
            |....|..|..|   |::|               ..:...|.:.:..: |.|||:|::
pombe   195 SGSYSLKRDLKD---YEEELPSSKKRQRTPPPIVVTNFPQEIFPSKKI-SLSAKRRIQGKYSGEN 255

  Fly   573 ----------------------------ALKQ---------RTATRQQQRNRDAVDC-AGRSGSG 599
                                        ||::         |.:||:..|.::|::. |.::||.
pombe   256 VRARIELARERNRKRDYVSNLSKGHTTNALEENPFNLGPNYRASTRKCNRIKEAINLFAAKNGSM 320

  Fly   600 SSSTTVKSEAGGLGLDETSFSVPTSPISLSTPLIDKETANSV----------PTSPEPSSLVPES 654
            .....|......|...:....|    |...|.|:..:.:|||          ||:..|::..|.|
pombe   321 EVPPKVSVGDSVLTTSQKFLQV----IREKTALLMNQDSNSVQPQALAAAESPTTKAPTTKAPTS 381

  Fly   655 SSGAGAGAVVVRRHNGHVVRKCDAAGFRTSKSEDHLQQIQREGIAAVIPIDIDEDVNSSLNTLLD 719
            .                            :..:.|::|:.::.....:|        .|:|.:..
pombe   382 E----------------------------APPKGHVKQLAKQLGNIYMP--------QSINNVEP 410

  Fly   720 TRQDSEDSQSMATVIVNNSS----------LASNNNEGEQTDNRSSSSSSNSSDNNNCSSNTGEP 774
            |      |.|..:.:||.|.          ||.|.|.     :.|.....|...|.:
pombe   411 T------SHSSISKVVNPSEKVISKIERACLAGNGNV-----HPSIKMEKNLELNPH-------- 456

  Fly   775 ATSETATATATIITA--------TSTRTMNCSSKLNYILCKKASDR-------DRIVWTYNAPLQ 824
              ..|..||...|.:        |.....|...|: |:| :..|||       ..::..|...:.
pombe   457 --PRTLNATEHKINSRIQVSKLNTKNELANADPKM-YLL-ENLSDRLYFCKLAKLLLRKYPLDIA 517

  Fly   825 PHQLAAL-QRQQQQQEQQFQQQQQQLHQQHLQQQQQLQQQHQQQQQQQQQQQQQQLYGQQSHSNS 888
            .||.|.: .|.|:...:|....:|.|
pombe   518 EHQFALVYSRFQRIPLKQISCLKQSL--------------------------------------- 543

  Fly   889 HSSSISSSPQHSAVGSPASPTSVSSSVMSSSGSKGALGLGSSSNGPMAAVQQQQLREREQGGQVA 953
                       .|..|..|...:::.:|                          |||..     .
pombe   544 -----------VAYYSVLSEVGITNEIM--------------------------LRENR-----F 566

  Fly   954 QPPSGIPGLLSCPGGGCGNNGGGGGIGGGGNNDQSVSEAISNISSPDYQDDDNLLSSRDILGGMV 1018
            ..|....||:|                            ||.:          ||..|:.|.
pombe   567 SSPKTPEGLVS----------------------------ISKL----------LLDDREHLS--- 590

  Fly  1019 LSDPSDSDSTILVSDAAAHQRQQLKQQLRAQQ----------QQQRERERDRDRDREQSEHKVVI 1073
                .|..|.|          |||:.|:::|.          ::.|.....|...::..| ||.:
pombe   591 ----HDERSYI----------QQLQSQIKSQSVHHENAAEEIRKMRNLRNSRINSQQVGE-KVFV 640

  Fly  1074 --QVRGLDSNSSGGNGTNGRSEEDVVTLTDEPLGTMTVGMRDASPPVSDDGSDVESLH------- 1129
              .|:.:|...     |..:..|| .|..:|  |......::....:||..||:.|..
pombe   641 NPDVKTMDIQE-----TFLQDYED-ETFANE--GLSASKFKEEFLLISDSKSDLNSEEIATPNSL 697

  Fly  1130 SYHYSPKAVDMPSAIRLAKRLHSLDGFKKSDVSRHLSKNNDFSRAVADEYLKHFTFEKKSLDQAL 1194
            .:..:|: :.:|.::.....||.....|..:|..    |::|...:             :|...|
pombe   698 EFKNNPR-IKVPRSLLTILNLHDRSQLKLFEVCH----NSEFKDPI-------------NLSNCL 744

  Fly  1195 REFLQQFSLS--------GETQERERVLVHFSKRF-------------LDCNPGTFNSQDAVHT- 1237
            |..|::..||        ....|.|.|.|.|...:             |.|:. .:.|.|.:|:
pombe   745 RNLLEKQLLSYNFTDWFASLGSEYENVYVKFISHYDFSSLNVYASFQKLCCDL-YYGSDDYIHSP 808

  Fly  1238 ----------------------LTCAIMLLNTDLHGQNINRKMS-----CAEFV----------- 1264
                                  :...|:|:..|||....::|::     ...||
pombe   809 ILQVFASCWLKQNSNYGFLNEDIIVKIVLILIDLHKSTYSKKLNSYVVPMETFVKYALEKLRPLI 873

  Fly  1265 --DNLADLNDGE-----------------------NFPKDV-------LKSLYQAIKTKPLEWAL 1297
              |::..|:..:                       |.|.|:       ||..|......|  :|:
pombe   874 SPDSVCILSKEDKKHWLKYKKNRSTFAKLLFSTWSNLPSDIGFILECMLKEYYDTFLKSP--FAV 936

  Fly  1298 ---------DEEAGDLQQQRANNSAL--------------------------------------- 1314
                     ::..|||..:| |.|:|
pombe   937 PNAVQAQLHNQVRGDLTPKR-NRSSLISELMKSSKLLKQESSGNKNSTSLESDAFKESSFVLNEE 1000

  Fly  1315 -GNVGLNPFLDPPELATAVE-------------------------YKKGYVMRKCCYDSSFKKTP 1353
             |.:.....:|.|| .:.::                         :::|.:        |:||..
pombe  1001 NGGIYAGKEIDLPE-PSVIDGRPHFSVFNYTHHMQEEKTHNRLPWHRRGMI--------SYKKMV 1056

  Fly  1354 FGKRS------WKMFYCTLRDLVLYLHKDEH----------------GFRKSQMSDNLHNAIRIH 1396
            ..|.:      ||..||.:....|..:|.:|                |.:....|.||..:|.
pombe  1057 LSKNNRWVAGYWKKKYCIVDSGKLIFYKSDHLDPNACSNVSPIHREFGLQSCLASPNLPPSIN-- 1119

  Fly  1397 HALATKANDYTKKQHVFRLQTADQAEYLFQTSDSKELQSWVETINYVCAAISAPPL-------EG 1454
                      :.:.:||.|.......|||:......:..|:.::|:..|.|:.|||       |.
pombe  1120 ----------SNRNNVFYLNIPGNECYLFEAPSVLAMNEWIHSLNFNAAMITCPPLPENITNTEY 1174

  Fly  1455 GVG-----SQKR--------------------------------FQRPLLPSKQSKLMLKEQLDS 1482
            |.|     ::|:                                ..|||    :.|:.:......
pombe  1175 GWGYILTRAEKKAYYTAADGTKTFVGDLAQLTRWSPMDIQGLQDIPRPL----RDKVHILRDCVP 1235

  Fly  1483 HEVQLAQLDQELNE--HKKGPIPSKGL--ALQNYKEKESYLQYELRRYRTYVSILSAK 1536
            ..::...|.|.|.|  .|.....||..  |:.|:..|..:|......|:.|..:|..:
pombe  1236 SLLETCLLFQSLPEKMEKCFAAGSKNYLKAMDNWNRKMKFLYERSMMYKEYQRVLECE 1293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Efa6	NP_001163691.2	PDZ_canonical	6..85	CDD:467153
		PHA03269	225..>344	CDD:165527
		Sec7	1124..1293	CDD:238100	42/267 (16%)
		PH_EFA6	1330..1452	CDD:270107	28/168 (17%)
spo7	NP_594113.1	PH	1057..1154	CDD:214574	20/108 (19%)