Protein Alignment Efa6 and psd

DIOPT Version :10

• Sequence 1: NP_001163691.2
• Gene: Efa6 / 42665
• FlyBaseID: FBgn0051158
• Length: 1601
• Species: Drosophila melanogaster
• Sequence 2: XP_031762195.1
• Gene: psd / 100497998
• XenbaseID: XB-GENE-6467347
• Length: 1174
• Species: Xenopus tropicalis
• Alignment Length: 1406
• Identity: 368/1406 - (26%)
• Similarity: 562/1406 - (39%)
• Gaps: 441/1406 - (31%)

  Fly   328 YMMTGDLILNLSRTPQTSNPLPAQAKKIDSLRDSPSRLVNPRINGALA-PRASGESSPTS----- 386
            |..||.|:.|.|.|...|..:.|....:.|..:.|  |.:|.....|. |:..|:||..:
 Frog    76 YNSTGSLVCNPSETVYKSGRVTAPCSPLRSRENDP--LYSPGSRKPLVLPQNLGQSSIVTFTFVK 138

  Fly   387 SSSVDSPTNTSS--DSVKREAKLLQKQQQQQQQTYQQQQQRDSINNSYNRKDSLTNDTLLMCEE- 448
            .|||.:....|:  ||               .|..||:|:.|.....||::...:     :|.|
 Frog   139 KSSVQTLNGVSTLCDS---------------DQDKQQRQEEDQRGPCYNKEKESS-----ICLEK 183

  Fly   449 --LEPDEEGEYVLEEDNKQ------QRQRQQQQRYRQQQNQQRYEYYQNEDELEEQEEVEEEREE 505
              :.||......|:..:.|      .|.|.|......|..|::|
 Frog   184 SAVNPDCISNTELKVGSPQLKLASHSRDRTQLACNSPQTGQRKY--------------------- 227

  Fly   506 DQTHYDITNIETYQSGVGRGDDDDSDRQCLVDDDDDDDAYDDEENDAGDEDYSTNS-LGSGSAKQ 569
             .:.:.|      ||.......|.:..|.:    .....||..:|.:.|...|||| |.:.|..|
 Frog   228 -HSEFGI------QSPSSASSQDFNLNQSV----SSSSQYDCSKNLSLDLKSSTNSPLKTSSPSQ 281

  Fly   570 RLRALKQRTATRQQQRN--RDAVDCAGRSGSGSSSTTVKS--------EAGGLGL---------- 614
              ..|.:|.|   ..||  :|.:..:.:..:..||::|:|        :|...|.
 Frog   282 --SPLLRRLA---NDRNACKDHITSSIQETNEESSSSVRSPRKSEPNQQADPWGFPKEVSLHAQK 341

  Fly   615 --------------------DETS-FSVPTSP----------ISLSTPL---------IDKETAN 639
                                ::|. .|.|.||          ....|.|         ::.||.:
 Frog   342 IAKAKWEFFYGSTDSQKEDSEQTEILSTPCSPNASGSLEKRHCHQETDLLKHNLCHVEVEIETTS 406

  Fly   640 SVPTSPEPSSLVPESSSGAGAGAVVVRRHNGHVVRKCDAAGFRTSKSEDHLQQIQREGIAAVIPI 704
            ||  .|:|.|    ..:|      ::||...:.....|:...|..: |.::..|..|
 Frog   407 SV--DPKPDS----CETG------IIRRTIKYSETDLDSVPLRCYR-ETNIDDILAE-------- 450

  Fly   705 DIDEDVNSSLNTLLDTRQDSEDSQSMATVIVNNSSLASNNNEGEQTDNRSSSSSSNSSDNNNCSS 769
                  |..|::.:.:::|||.         |..:.|...||    .|..::..:|....||...
 Frog   451 ------NEGLDSAIGSQKDSES---------NTETSAEKTNE----QNEQTTVENNRVFANNPGR 496

  Fly   770 NTGEPATSETATATATIITATSTRTMNCSSKLNYILCKKASDRDRIVWTYNAPLQPHQLAALQRQ 834
            :.||....|...||....|......:...:.|.::||                   |:|:
 Frog   497 DNGEEDEDEVFEATKVGETNRVNAQLPIKTPLPFLLC-------------------HRLS----- 537

  Fly   835 QQQQEQQFQQQQQQLHQQHLQQQQQLQQQHQQQQQQQQQQQQQQLYGQQSHSNSHSSSISSSP-- 897
             :.....|.:..:.:.:.|..:                         ..|:|:..|..|.|||
 Frog   538 -EDGMDSFSKHFENIMESHRAK-------------------------GTSYSSLDSIDILSSPAQ 576

  Fly   898 -QHS--AVGSPASPTSVSSSVMSSSGSKGALGLGSSSNGPMAAVQQQQLREREQGGQVAQPPSGI 959
             |||  ....|...:.....:..::      .|...:..|:|.::...
 Frog   577 NQHSFFTFDLPTLTSETQKQICKNA------QLIEDNFAPLAHLELDS----------------- 618

  Fly   960 PGLLSCPGGGCGNNGGGGGIGGGGNNDQSVSEAISNISSPDYQDDDNLLSSRDILGGM--VLSDP 1022
                                |.....|.:.||          ::||.:    :..|..  .|..|
 Frog   619 --------------------GTSSTTDSAWSE----------REDDTV----NAAGATNNALRSP 649

  Fly  1023 SDSDSTILVSDAAAHQRQQLKQQLRAQQQQQRERERDRDRDREQSEHKVVIQVRGLDSNSSGGNG 1087
            :.|:.:::::||                                     :||
 Frog   650 TQSEDSLIIADA-------------------------------------IIQ------------- 664

  Fly  1088 TNGRSEEDVVTLTDEPLGTMTVGMRDASPPVSDDGSDVES-----------LHSYHYSPKAVDMP 1141
                        ::.|||.:          .|:..|:::|           |.:.|   || |..
 Frog   665 ------------SEPPLGNL----------ASEFDSEMDSTERLALGSTDTLSNGH---KA-DQE 703

  Fly  1142 SAIRLAKRLHSLDGFKKSDVSRHLSKN--NDFSRAVADEYLKHFTFEKKSLDQALREFLQQFSLS 1204
            :|.||||||::||||||:||:|||.|.  |:||:.||:||||.|.|...|||||||.||::.:|.
 Frog   704 AAKRLAKRLYNLDGFKKADVARHLGKKYVNEFSKMVAEEYLKFFVFTGMSLDQALRMFLKELALM 768

  Fly  1205 GETQERERVLVHFSKRFLDCNPGTFNSQDAVHTLTCAIMLLNTDLHGQNINRKMSCAEFVDNLAD 1269
            ||||||||:|.|||:|:..||..:..|:|.|||||||:|||||||||.||.::|||:||:.||..
 Frog   769 GETQERERILAHFSQRYHQCNSNSITSEDGVHTLTCALMLLNTDLHGHNIGKRMSCSEFIGNLEG 833

  Fly  1270 LNDGENFPKDVLKSLYQAIKTKPLEWALDEEAGDLQQ-------------QRANNSALGNVGLNP 1321
            ||.|::||:::||:||.:||.:.|:|.:|||  :|::             :|.|:..      .|
 Frog   834 LNGGKDFPRELLKALYSSIKNEKLQWTIDEE--ELRRSLSELADPNPKSIKRINSCG------KP 890

  Fly  1322 FLD---PPELATAVEYKKGYVMRKCCYDSSFKKTPFGKRSWKMFYCTLRDLVLYLHKDEHGFRKS 1383
            |||   .|.:.|   ||.|.::||...|...||||.|||.||.|:..|:.::|||.|:|:...|.
 Frog   891 FLDFSQDPNITT---YKYGVLVRKTHADPDCKKTPRGKRGWKTFHGILKGMILYLQKEEYKPGKP 952

  Fly  1384 QMSDNLHNAIRIHHALATKANDYTKKQHVFRLQTADQAEYLFQTSDSKELQSWVETINYVCAAIS 1448
            ...::|.|||.|||:|||:|:||.|:.:||.|:|||...:|||..:.:::.||:..||.|.|..|
 Frog   953 LSEEDLKNAISIHHSLATRASDYNKRPNVFYLRTADWRVFLFQAQNPEQMHSWITRINVVAAMFS 1017

  Fly  1449 APPLEGGVGSQKRFQRPLLPSKQSKLMLKEQLDSHEVQLAQLDQELNEHKKGPIPS---KGLALQ 1510
            |||....:||.|:|.||||||..::|..:||:.:||.:...:...|.||:..| |.   ||..::
 Frog  1018 APPFPAAIGSYKKFSRPLLPSSITRLSQEEQVKTHESKFKTMSSSLIEHRSSP-PDKKIKGKEIE 1081

  Fly  1511 NYKEKESYLQYELRRYRTYVSILSAKMLADQQQLE----------------LQAQQPSPASHEEE 1559
            .:|:||.||::|..||.||..:|.||:.|..:.||                |:..:.||:.:.:
 Frog  1082 EFKQKEDYLEFEKSRYGTYAMLLRAKLKAGTEDLEAFETTLFDSAENDDDGLKKSRSSPSLNID- 1145

  Fly  1560 ADTFPVGTTACTPPTPQSINQKDQQKEQQQQQPTNRKEKKK 1600
                         |.|.|...|.....:...:|.:...::|
 Frog  1146 -------------PPPASTKAKCHVSSRGSCRPAHSSSRQK 1173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Efa6	NP_001163691.2	PDZ_canonical	6..85	CDD:467153
		PHA03269	225..>344	CDD:165527	7/15 (47%)
		Sec7	1124..1293	CDD:238100	99/181 (55%)
		PH_EFA6	1330..1452	CDD:270107	56/121 (46%)
psd	XP_031762195.1	Sec7	701..857	CDD:238100	94/155 (61%)
		PH_EFA6	897..1022	CDD:270107	58/127 (46%)