DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dph5 and dph5

DIOPT Version :9

Sequence 1:	NP_524452.4	Gene:	Dph5 / 42663	FlyBaseID:	FBgn0024558	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_588441.1	Gene:	dph5 / 2539471	PomBaseID:	SPCC576.14	Length:	283	Species:	Schizosaccharomyces pombe

Alignment Length:	280	Identity:	147/280 - (52%)
Similarity:	202/280 - (72%)	Gaps:	6/280 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFYLIGLGLGDLKDITVKGLEIVKQCSRVYLEMYTSILGCSLEDMQEFYGRPLLLADRDLVEQGA 65
            |||||||||.|.||||::|||.||:|.|:|||.|||||....|.::|.||:.::||||::||..:
pombe     1 MFYLIGLGLFDEKDITLRGLETVKKCQRIYLEAYTSILLVQKEKLEELYGKEVILADREMVESSS 65

  Fly    66 DEILAGAGESDVALLVVGDPFGATTHTDFILRAKEKNIPYKVIHNASIMNAVGCCGLQLYKFGET 130
            ||||..|...|||:||||||.|||||.|.::||:|..||.::|||||||||:|.|||||||||:|
pombe    66 DEILKDADNCDVAMLVVGDPMGATTHADLVIRARELKIPVRMIHNASIMNAIGACGLQLYKFGQT 130

  Fly   131 VSIPYWDETWKPDSFYDKIKLNRLHNMHTLCLLDIKVKEPTPESLMRKRKEYMPPRFMTVAEAAH 195
            ||:.:::..::|.||||.||.|....:|||.||||||||.:.|:|.|.||.|.|||:|:.:.||.
pombe   131 VSLVFFENNYRPQSFYDHIKENVSLGLHTLVLLDIKVKEQSWENLARGRKVYEPPRYMSASLAAQ 195

  Fly   196 QLLSIVEKKDSLEKNTVLNEQSLCVGLARVGQESQQIAVGTLLEMRSTDLGGPLHSLIIPAKEMH 260
            |:|.:.|.:    :..:....||||.:.|:|.:.|.|..|||.|:...|:|.||||:::..:::|
pombe   196 QMLEVEEDR----QENICTPDSLCVAVGRMGSDDQVIFAGTLQELAEHDIGPPLHSVVLVGRDVH 256

  Fly   261 PLEVEFLQQYAPSIKLDDYN 280
            .||:|||:.||  :.|::::
pombe   257 DLELEFLRAYA--VNLENFD 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dph5	NP_524452.4	PTZ00175	1..270	CDD:185500	144/268 (54%)
dph5	NP_588441.1	PTZ00175	1..266	CDD:185500	144/268 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	264	1.000	Domainoid score	I357
eggNOG	1	0.900	-	-		E1_COG1798
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6471
Inparanoid	1	1.050	299	1.000	Inparanoid score	I608
OMA	1	1.010	-	-		QHG62266
OrthoFinder	1	1.000	-	-		FOG0005194
OrthoInspector	1	1.000	-	-		oto100513
orthoMCL	1	0.900	-	-		OOG6_101531
Panther	1	1.100	-	-	LDO	PTHR10882
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R340
SonicParanoid	1	1.000	-	-		X3707
TreeFam	1	0.960	-	-
	14	13.860