DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CSN6 and Cops6

DIOPT Version :9

Sequence 1:	NP_524451.1	Gene:	CSN6 / 42661	FlyBaseID:	FBgn0028837	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_036132.1	Gene:	Cops6 / 26893	MGIID:	1349439	Length:	324	Species:	Mus musculus

Alignment Length:	333	Identity:	192/333 - (57%)
Similarity:	256/333 - (76%)	Gaps:	10/333 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MSAKPSTSSSAAAGSS-MAVDKTADQNPQPQGNIMAAAGTSGSVTISLHPLVIMNISEHWTRFRA 73
            |:|..:..::.:.||| |.||.....        :.|:|.:|||:::||||||:|||:||.|.|:
Mouse     1 MAAAAAAGANGSGGSSGMEVDAAVPS--------VMASGVTGSVSVALHPLVILNISDHWIRMRS 57

  Fly    74 QHGEPRQVYGALIGKQKGRNIEIMNSFELKTDVIGDETVINKDYYNKKEQQYKQVFSDLDFIGWY 138
            |.|.|.||.|||||||:|||||:||||||.:..:.::.:|:|:||..||:|:||||.:|:|:|||
Mouse    58 QEGRPMQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWY 122

  Fly   139 TTGDNPTADDIKIQRQIAAINECPIMLQLNPLSRSVDHLPLKLFESLIDLVDGEATMLFVPLTYT 203
            |||..|...||.:.:|:..|.|.|:.|:|||:::..| ||:.:|||:||:::|||||||..||||
Mouse   123 TTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTD-LPVSVFESVIDIINGEATMLFAELTYT 186

  Fly   204 LATEEAERIGVDHVARMTSNESGEKSVVAEHLVAQDSAIKMLNTRIKIVLQYIRDVEAGKLRANQ 268
            ||||||||||||||||||:..|||.|.|||||:||.||||||::|:|::|:|::..|||::..|.
Mouse   187 LATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNH 251

  Fly   269 EILREAYALCHRLPVMQVPAFQEEFYTQCNDVGLISYLGTLTKGCNDMHHFVNKFNMLYDRQGSA 333
            |||||||||||.|||:....|:.:||.|||||||::||||:||.||.|:.||||||:||||||..
Mouse   252 EILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIG 316

  Fly   334 RRMRGLYY 341
            ||||||::
Mouse   317 RRMRGLFF 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN6	NP_524451.1	MPN_CSN6	52..335	CDD:163694	174/282 (62%)
Cops6	NP_036132.1	MPN_CSN6	36..318	CDD:163694	174/282 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837266
Domainoid	1	1.000	158	1.000	Domainoid score	I4142
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4977
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1938
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55514
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005913
OrthoInspector	1	1.000	-	-		oto94427
orthoMCL	1	0.900	-	-		OOG6_103125
Panther	1	1.100	-	-	LDO	PTHR10540
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4523
SonicParanoid	1	1.000	-	-		X4896
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790