DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CSN6 and MYSM1

DIOPT Version :9

Sequence 1:	NP_524451.1	Gene:	CSN6 / 42661	FlyBaseID:	FBgn0028837	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001078956.1	Gene:	MYSM1 / 114803	HGNCID:	29401	Length:	828	Species:	Homo sapiens

Alignment Length:	317	Identity:	63/317 - (19%)
Similarity:	110/317 - (34%)	Gaps:	90/317 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 QGNIMAAAGT---SGSVTISLHPLVIMNISEHW--TRFRAQHGEPRQVYGALIGKQKGRNIEIMN 98
            :|:::||||.   ||..|.|:..      .:|:  :.:|.::|.........|.::....||.|
Human    11 EGDVVAAAGAQPGSGENTASVLQ------KDHYLDSSWRTENGLIPWTLDNTISEENRAVIEKM- 68

  Fly    99 SFELKTDVIGDETVINKDYYNKKEQQYKQVFSDLDFIGWYTTGDNPTADDIKIQRQIAAINECPI 163
                         ::.::||..|:.|.::|:.|            ...||.|..:.:....:..:
Human    69 -------------LLEEEYYLSKKSQPEKVWLD------------QKEDDKKYMKSLQKTAKIMV 108

  Fly   164 MLQLNPLSRSVDHL--PLKLFE----------SLIDLVDGEATMLFVPLTYTLATEEAERIGVD- 215
            .....|.|.||...  ..:|||          :.|..:.|..|:|.|........:...:.|:|
Human   109 HSPTKPASYSVKWTIEEKELFEQGLAKFGRRWTKISKLIGSRTVLQVKSYARQYFKNKVKCGLDK 173

  Fly   216 --------HVARMTSNESGEKSVVAEHLVAQDSAIKMLNTRIKIVLQYIRDVEAGKLRANQE--I 270
                    |..::.:.:.|.|:.....|  :..|...||.           |:..||..::|  |
Human   174 ETPNQKTGHNLQVKNEDKGTKAWTPSCL--RGRADPNLNA-----------VKIEKLSDDEEVDI 225

  Fly   271 LREAYALCHRLP--------VMQVP------AFQEEFYTQCNDVGLISYLGTLTKGC 313
            ..|...|..:.|        ::..|      ..|.||.|..:...|.|   ..::||
Human   226 TDEVDELSSQTPQKNSSSDLLLDFPNSKMHETNQGEFITSDSQEALFS---KSSRGC 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN6	NP_524451.1	MPN_CSN6	52..335	CDD:163694	56/301 (19%)
MYSM1	NP_001078956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		8/19 (42%)
		SANT	120..164	CDD:197842	8/43 (19%)
		Myb_DNA-binding	120..162	CDD:278669	8/41 (20%)
		SWIRM	382..461	CDD:282311
		MPN_2A_DUB	571..753	CDD:163698
		JAMM motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01182	656..669
		LXXLL motif	774..778
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900