Protein Alignment CSN6 and COPS6

DIOPT Version :10

• Sequence 1: NP_524451.1
• Gene: CSN6 / 42661
• FlyBaseID: FBgn0028837
• Length: 341
• Species: Drosophila melanogaster
• Sequence 2: NP_006824.2
• Gene: COPS6 / 10980
• HGNCID: 21749
• Length: 327
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 191/332 - (57%)
• Similarity: 255/332 - (76%)
• Gaps: 9/332 - (2%)

  Fly    11 SAKPSTSSSAAAGSS-MAVDKTADQNPQPQGNIMAAAGTSGSVTISLHPLVIMNISEHWTRFRAQ 74
            :|..:.:::...||| |.||.....:       :.|.|.:|||:::||||||:|||:||.|.|:|
Human     4 AAAAAAATNGTGGSSGMEVDAAVVPS-------VMACGVTGSVSVALHPLVILNISDHWIRMRSQ 61

  Fly    75 HGEPRQVYGALIGKQKGRNIEIMNSFELKTDVIGDETVINKDYYNKKEQQYKQVFSDLDFIGWYT 139
            .|.|.||.|||||||:|||||:||||||.:..:.::.:|:|:||..||:|:||||.:|:|:||||
Human    62 EGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYT 126

  Fly   140 TGDNPTADDIKIQRQIAAINECPIMLQLNPLSRSVDHLPLKLFESLIDLVDGEATMLFVPLTYTL 204
            ||..|...||.:.:|:..|.|.|:.|:|||:::..| ||:.:|||:||:::|||||||..|||||
Human   127 TGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTD-LPVSVFESVIDIINGEATMLFAELTYTL 190

  Fly   205 ATEEAERIGVDHVARMTSNESGEKSVVAEHLVAQDSAIKMLNTRIKIVLQYIRDVEAGKLRANQE 269
            |||||||||||||||||:..|||.|.|||||:||.||||||::|:|::|:|::..|||::..|.|
Human   191 ATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHE 255

  Fly   270 ILREAYALCHRLPVMQVPAFQEEFYTQCNDVGLISYLGTLTKGCNDMHHFVNKFNMLYDRQGSAR 334
            ||||||||||.|||:....|:.:||.|||||||::||||:||.||.|:.||||||:||||||..|
Human   256 ILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIGR 320

  Fly   335 RMRGLYY 341
            |||||::
Human   321 RMRGLFF 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CSN6	NP_524451.1	MPN_CSN6	52..335	CDD:163694	174/282 (62%)
COPS6	NP_006824.2	MPN_CSN6	39..321	CDD:163694	174/282 (62%)
		Interaction with Vpr	211..327		76/115 (66%)