DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdipoR and IZH2

DIOPT Version :9

Sequence 1:	NP_001247239.1	Gene:	AdipoR / 42656	FlyBaseID:	FBgn0038984	Length:	444	Species:	Drosophila melanogaster
Sequence 2:	NP_014641.2	Gene:	IZH2 / 854160	SGDID:	S000005362	Length:	317	Species:	Saccharomyces cerevisiae

Alignment Length:	292	Identity:	117/292 - (40%)
Similarity:	169/292 - (57%)	Gaps:	19/292 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 GALAHNAAE--QAEEFVRKVWEASWKVCHYKNLPKWLQDNDFLHRGHRPPLPSFRACFKSIFRVH 201
            |..:.|.||  :|::.:|:::  ||     ..:|:|.:||||:..|:.....||...|||:|.:|
Yeast    20 GKTSANPAEVAKAKKVLRRLY--SW-----DEIPEWQRDNDFILHGYVKETSSFIETFKSLFYLH 77

  Fly   202 TETGNIWTHLLGCIAFIGVALYFISRPSVEIQTQ--EKIVFGAFFIGAIVCLGFSFAFHTLSCHS 264
            .|:.||::||:..:.|..|.|...|...|...|.  :.:|...|:.||..||..|.:||.|..||
Yeast    78 NESVNIYSHLIPALGFFTVLLLDKSTIKVFATTTWLDHMVIDLFYSGAFACLILSSSFHCLKSHS 142

  Fly   265 VEMGRLFSKLDYCGIALLIMGSFVPWLYYGFYCHYQPKVIYLSVVSILGILSIVVSLWDKFSEPA 329
            :.:..|.:||||.||.:||:.|.|..||||::..:....::..:....||...:|||.|||.:..
Yeast   143 LRIATLGNKLDYLGICILIVTSMVSILYYGYFEKFSLFCLFALITVSFGIACSIVSLKDKFRKRE 207

  Fly   330 LRPLRAGVFMSFGLSGVIPAIH----YSIMEGWFSQMSRASLGWLILMGLLYILGALLYALRVPE 390
            .||.|||:|:.||||.:||...    ||..|.|    ::..|.|::|.|:|||:||:||.:|.||
Yeast   208 WRPYRAGLFVCFGLSSIIPIFSGLYCYSFSEIW----TQIQLFWVLLGGVLYIIGAVLYGMRFPE 268

  Fly   391 RWFPGKFDIWGQSHQIFHILVIAAAFVHYHGI 422
            :..||||||||.|||:||.||:.||..|..|:
Yeast   269 KICPGKFDIWGHSHQLFHFLVVIAALCHLRGL 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdipoR	NP_001247239.1	HlyIII	198..419	CDD:397239	95/226 (42%)
IZH2	NP_014641.2	HlyIII	74..297	CDD:397239	95/226 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344040
Domainoid	1	1.000	175	1.000	Domainoid score	I739
eggNOG	1	0.900	-	-		E1_COG1272
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69199
Inparanoid	1	1.050	206	1.000	Inparanoid score	I830
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53658
OrthoFinder	1	1.000	-	-		FOG0001022
OrthoInspector	1	1.000	-	-		otm46495
orthoMCL	1	0.900	-	-		OOG6_100486
Panther	1	1.100	-	-	LDO	PTHR20855
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R26
SonicParanoid	1	1.000	-	-		X679
TreeFam	1	0.960	-	-
	15	14.790