DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdipoR and IZH1

DIOPT Version :9

Sequence 1:	NP_001247239.1	Gene:	AdipoR / 42656	FlyBaseID:	FBgn0038984	Length:	444	Species:	Drosophila melanogaster
Sequence 2:	NP_010780.1	Gene:	IZH1 / 852102	SGDID:	S000002900	Length:	316	Species:	Saccharomyces cerevisiae

Alignment Length:	287	Identity:	97/287 - (33%)
Similarity:	149/287 - (51%)	Gaps:	16/287 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 VWEASWKVCHYKNLPKWLQDNDFLHRGHRPPLPSFRACFKSIFRVHTETGNIWTHLLGCIAFIGV 220
            |:|....:.::..||:|.:|||.:..|:.....|::.|..|:|..:.||.||:|||:..|.:...
Yeast    33 VFEKQKLLHNFDELPEWQKDNDKILTGYVRETLSWKKCLYSLFYWNNETVNIYTHLVPAIVYFVF 97

  Fly   221 AL----YFISRPSVEIQTQEKIVFGAFFIGAIVCLGFSFAFHTLSCHSVEMGRLFSKLDYCGIAL 281
            |:    ||:..........:..|...|.:||..||..|..||.:..||.:....:|||||.||..
Yeast    98 AITLTNYFLIPVFPSTSWSDYTVINIFLMGAFSCLMCSSCFHCMKQHSEKQSNFWSKLDYLGIIS 162

  Fly   282 LIMGSFVPWLYYGFYCHYQPKVIYLSVVSILGILSIVVSLWDKFSEPALRPLRAGVFMSFGLSGV 346
            ||..|.:|.:|:|::.|.....::..|..:|.....|..|.|||:....||.||..|:.||.||:
Yeast   163 LISCSMIPIIYFGYFDHISYFSLFTIVTLVLATFCTVCVLHDKFNTSTFRPFRAMFFILFGFSGL 227

  Fly   347 IPAIHYSIMEGWF-----SQMSRASLGWLILMGLLYILGALLYALRVPERWFPGKFDIWGQSHQI 406
            :|     :..|:|     ..::|..:.::....|.||.||::|..|:||...|||||.:|.||||
Yeast   228 LP-----LTTGFFKFGIQGVLNRIKVSFVFWEALFYISGAVIYGFRIPETLAPGKFDFFGSSHQI 287

  Fly   407 FHILVIAAAFVHYHGISEMAMYRVMYS 433
            |||:|:..:..|...|.:  .|::|:|
Yeast   288 FHIMVVLGSVCHLKAIID--SYKLMHS 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdipoR	NP_001247239.1	HlyIII	198..419	CDD:397239	80/229 (35%)
IZH1	NP_010780.1	HlyIII	75..300	CDD:397239	80/229 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344041
Domainoid	1	1.000	175	1.000	Domainoid score	I739
eggNOG	1	0.900	-	-		E1_COG1272
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I830
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53658
OrthoFinder	1	1.000	-	-		FOG0001022
OrthoInspector	1	1.000	-	-		otm46495
orthoMCL	1	0.900	-	-		OOG6_100486
Panther	1	1.100	-	-	O	PTHR20855
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X679
TreeFam	1	0.960	-	-
	13	12.760