DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdipoR and ADIPOR2

DIOPT Version :9

Sequence 1:	NP_001247239.1	Gene:	AdipoR / 42656	FlyBaseID:	FBgn0038984	Length:	444	Species:	Drosophila melanogaster
Sequence 2:	NP_001362292.1	Gene:	ADIPOR2 / 79602	HGNCID:	24041	Length:	419	Species:	Homo sapiens

Alignment Length:	405	Identity:	195/405 - (48%)
Similarity:	246/405 - (60%)	Gaps:	77/405 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 EDDAGCPLPSTPE-----------------DTQLIEAEMTEVLKAGVL-------------SDEI 136
            |:..||  ..|||                 |....:.::..:|:|.||             |||.
Human     6 ENRLGC--SRTPEPDIRLRKGHQLDGTRRGDNDSHQGDLEPILEASVLSSHHKKSSEEHEYSDEA 68

  Fly   137 ---DLGAL-------AHNAAEQAEEFVRKVWEASWKVCHYKNLPKWLQDNDFLHRGHRPPLPSFR 191
               |.|.:       ||:|.|:.||||.||||..|:|..:..||.||:|||||..|||||:||||
Human    69 PQEDEGFMGMSPLLQAHHAMEKMEEFVCKVWEGRWRVIPHDVLPDWLKDNDFLLHGHRPPMPSFR 133

  Fly   192 ACFKSIFRVHTETGNIWTHLLGCIAFIGVALYFISRPSVEI--QTQEKIVFGAFFIGAIVCLGFS 254
            ||||||||:||||||||||||||:.|:.:.::::.||::..  ..|||:|||.||:|||:||.||
Human   134 ACFKSIFRIHTETGNIWTHLLGCVFFLCLGIFYMFRPNISFVAPLQEKVVFGLFFLGAILCLSFS 198

  Fly   255 FAFHTLSCHSVEMGRLFSKLDYCGIALLIMGSFVPWLYYGFYCHYQPKVIYLSVVSILGILSIVV 319
            :.|||:.|||..:.||||||||.||||||||||||||||.|||:.||..|||.|:.:|||.:|:|
Human   199 WLFHTVYCHSEGVSRLFSKLDYSGIALLIMGSFVPWLYYSFYCNPQPCFIYLIVICVLGIAAIIV 263

  Fly   320 SLWDKFSEPALRPLRA---------------------------------GVFMSFGLSGVIPAIH 351
            |.||.|:.|..|.:||                                 |||:..||||:||.:|
Human   264 SQWDMFATPQYRGVRAVLLCSPGWSAVVPSWLLTSSDLPASASQSAGITGVFLGLGLSGIIPTLH 328

  Fly   352 YSIMEGWFSQMSRASLGWLILMGLLYILGALLYALRVPERWFPGKFDIWGQSHQIFHILVIAAAF 416
            |.|.||:....:...:|||:||..|||.||.|||.|:|||:||||.|||..|||:|||.|:|.||
Human   329 YVISEGFLKAATIGQIGWLMLMASLYITGAALYAARIPERFFPGKCDIWFHSHQLFHIFVVAGAF 393

  Fly   417 VHYHGISEMAMYRVM 431
            ||:||:|.:..:|.|
Human   394 VHFHGVSNLQEFRFM 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdipoR	NP_001247239.1	HlyIII	198..419	CDD:397239	135/255 (53%)
ADIPOR2	NP_001362292.1	HlyIII	140..396	CDD:367292	135/255 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I1437
eggNOG	1	0.900	-	-		E1_COG1272
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	394	1.000	Inparanoid score	I1980
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53658
OrthoDB	1	1.010	-	-		D1524940at2759
OrthoFinder	1	1.000	-	-		FOG0001022
OrthoInspector	1	1.000	-	-		otm40326
orthoMCL	1	0.900	-	-		OOG6_100486
Panther	1	1.100	-	-	LDO	PTHR20855
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R26
SonicParanoid	1	1.000	-	-		X679
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870