Protein Alignment AdipoR and PAQR3

DIOPT Version :10

• Sequence 1: NP_651061.1
• Gene: AdipoR / 42656
• FlyBaseID: FBgn0038984
• Length: 444
• Species: Drosophila melanogaster
• Sequence 2: NP_001035292.1
• Gene: PAQR3 / 152559
• HGNCID: 30130
• Length: 311
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 84/268 - (31%)
• Similarity: 141/268 - (52%)
• Gaps: 5/268 - (1%)

  Fly   166 YKNLPKWLQDNDFLHRGHRPPLPSFRACFKSIFRVHTETGNIWTHLLGCIAFIGVALYFISR--P 228
            |:.:|..|:||.::..|:|..||| |.|.||:|.:..||.|||:||||...|..:.:|.::.  |
Human    33 YEQIPGSLKDNPYITDGYRAYLPS-RLCIKSLFILSNETVNIWSHLLGFFLFFTLGIYDMTSVLP 96

  Fly   229 SVEIQTQEKIVFGAFFIGAIVCLGFSFAFHTLSCH-SVEMGRLFSKLDYCGIALLIMGSFVPWLY 292
            |.....::.::.........||:..|..:|..||| |.:..|.:..|||.||::.|:|.:|..::
Human    97 SASASREDFVICSICLFCFQVCMLCSVGYHLFSCHRSEKTCRRWMALDYAGISIGILGCYVSGVF 161

  Fly   293 YGFYCHYQPKVIYLSVVSILGILSIVVSLWDKFSEPALRPLRAGVFMSFGLSGVIPAIHYSIMEG 357
            |.|||:...:.:||..|..:.:......:...:.....:.||:.:|.|....||||.:|:..:.|
Human   162 YAFYCNNYWRQVYLITVLAMILAVFFAQIHPNYLTQQWQRLRSIIFCSVSGYGVIPTLHWVWLNG 226

  Fly   358 WF-SQMSRASLGWLILMGLLYILGALLYALRVPERWFPGKFDIWGQSHQIFHILVIAAAFVHYHG 421
            .. :.:.:.....:|:|.::.:|..|.|..:||||:|||:.:..|.||||:|||.:...:..:..
Human   227 GIGAPIVQDFAPRVIVMYMIALLAFLFYISKVPERYFPGQLNYLGSSHQIWHILAVVMLYWWHQS 291

  Fly   422 ISEMAMYR 429
            ...:..||
Human   292 TVYVMQYR 299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdipoR	NP_651061.1	HlyIII	198..419	CDD:427098	68/224 (30%)
PAQR3	NP_001035292.1	Required for interaction with SREBF2. /evidence=ECO:0000269|PubMed:26311497	1..20
		Required for interaction with SCAP. /evidence=ECO:0000269|PubMed:26311497	41..60		8/19 (42%)
		Golgi targeting. /evidence=ECO:0000269|PubMed:18547165	61..71		4/9 (44%)
		HlyIII	64..283	CDD:427098	68/218 (31%)
		Golgi targeting. /evidence=ECO:0000269|PubMed:18547165	299..303		1/1 (100%)