DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta1R and adrb3b

DIOPT Version :9

Sequence 1:	NP_001262843.1	Gene:	Octbeta1R / 42652	FlyBaseID:	FBgn0038980	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_021334880.1	Gene:	adrb3b / 792519	ZFINID:	ZDB-GENE-081022-154	Length:	417	Species:	Danio rerio

Alignment Length:	420	Identity:	129/420 - (30%)
Similarity:	218/420 - (51%)	Gaps:	73/420 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 IGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSV 178
            :..:|...::||:|||:::.|...|...||.|::|:|.||:::.........|::::|||:.|:.
Zfish    21 LALVIFLTVIGNLLVILAIARTPLLHTTTNVFIISMAFADLIMGCVVQPLGLSMVVAGKWVLGNP 85

  Fly   179 MCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPI 243
            |||:|.|.||:..||||..||.|:|:||.||.:||::.:::.:||...::..||:..:|:||:||
Zfish    86 MCDLWTSLDVFCVTASIETLCAIAVERYIAITRPLEHQVLLGKRRAAYIVCTVWIVSSLVSFVPI 150

  Fly   244 CSGWYTTTENYKYLK---SNPHICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERL 305
            .:  :.:..||....   :|...|:|..|:.|||.||.:||::|.:||:.:|.:::..|::|.:|
Zfish   151 MN--HNSRANYLAANDCYNNSECCDFHTNQHYAIFSSVVSFYVPLLVMVFLYGKVFAIANKQLKL 213

  Fly   306 VYRSKVAALLLEKHLQISQIPKPRPSIQVEQSTISTMRR-------ERKAARTLGIIMSAFLICW 363
            :.:.:: ..|...:....:||        |.|..|..||       |.||.:||||||..|.:||
Zfish   214 IGKDRL-RFLSSCNEDSCEIP--------EGSARSYSRRTTKHVVKEHKALKTLGIIMGIFSLCW 269

  Fly   364 LPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKTLKSLFP---- 424
            ||||::.|:.|. :..:..:|:..:|.|:||.||.||||||.: :.::|.||...|....|
Zfish   270 LPFFIFNIIKSF-NPEVPTQLVFLLLNWLGYANSGLNPIIYCH-SPEYRNAFFNLLGCKKPKHFN 332

  Fly   425 --------YAFYFCRRGR--------GRDDDRDLEFGGPSRRGTNGAQRTGSGSAEMANCVNSTA 473
                    .:|..|.:..        |..|        |..||       |:..::|:
Zfish   333 QTTVNKHLQSFTSCIQSNSSVRMDCMGHKD--------PIARG-------GNTCSDMS------- 375

  Fly   474 SSEIHMSVMRARQYAVNVTPTTDAQMQQLH 503
                  ||::..:  |.:.|..|:.|..::
Zfish   376 ------SVLKGEE--VEIQPHNDSTMTMIN 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_001262843.1	7tm_4	112..>231	CDD:304433	43/116 (37%)
Octbeta1R	NP_001262843.1	7tm_1	124..404	CDD:278431	106/289 (37%)
adrb3b	XP_021334880.1	7tmA_Beta_AR	25..319	CDD:320186	110/306 (36%)
		TM helix 2	49..76	CDD:320186	8/26 (31%)
		TM helix 3	87..117	CDD:320186	17/29 (59%)
		TM helix 4	131..149	CDD:320186	5/17 (29%)
		TM helix 5	177..209	CDD:320186	13/31 (42%)
		TM helix 6	249..279	CDD:320186	17/29 (59%)
		TM helix 7	288..313	CDD:320186	13/25 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328277at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107218
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X822
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920