DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta1R and si:dkey-247m21.3

DIOPT Version :9

Sequence 1:	NP_001262843.1	Gene:	Octbeta1R / 42652	FlyBaseID:	FBgn0038980	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_017208337.2	Gene:	si:dkey-247m21.3 / 559089	ZFINID:	ZDB-GENE-091204-249	Length:	390	Species:	Danio rerio

Alignment Length:	412	Identity:	148/412 - (35%)
Similarity:	218/412 - (52%)	Gaps:	54/412 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 ASEGSTDDADG--SSHLALVFVKCFIIGFIILAAILGNMLVIVSVMRHRKLR-IITNYFVVSLAV 151
            ||:.:.|..|.  |.|.:.:.:...::..||:.| |||:||:|::.:.|:|| ..||:|:||||.
Zfish     4 ASDSAEDSVDEVVSKHTSRITLSIVLVTIIIMTA-LGNLLVMVALCKDRQLRKKKTNFFIVSLAF 67

  Fly   152 ADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAI-VQPLDY 215
            ||:||||..|...|..:.:|||.:|...|.:..|.||..:||||:|||||::|||||| .|||.|
Zfish    68 ADLLVALVVMPLAAIELTTGKWNYGETFCLVRTSLDVLLTTASILHLCCIALDRYYAICCQPLVY 132

  Fly   216 PLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTT-----TENYKYLKSNPHICEFKVNKAYAIV 275
            ...||..||.:||:..|:.|..:|||||...|.|.     .|..|...|....|.|.||:.||:|
Zfish   133 NNKMTPVRVSLMLVGCWVIPFFISFLPIMQSWNTIGIESFIEQRKLNSSRNSTCVFMVNQPYALV 197

  Fly   276 SSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQISQIPKPRPSIQVEQSTIS 340
            .|:::|::|.::|:..|.|||..|     :.:..::.:|........|..|..      :|...|
Zfish   198 CSAVAFYVPLVLMVLAYQRIYVTA-----MGHARRIGSLHRAGSAPTSTYPNN------DQHGSS 251

  Fly   341 TMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYA 405
            .::.|.|||:||.:||..|.:||.|||:..:|....:..:..::....| |:||.||.|||.:||
Zfish   252 RIKNETKAAKTLAVIMGCFCLCWAPFFVTNVVDPFINYSVPWQMWTAWL-WLGYINSGLNPFLYA 315

  Fly   406 YFNRDFRAAFKKTLKSLFPYAFYFCRRGRGRDDDRDLEFGG--PSRRGTNGAQRTGSGSAEMANC 468
            :.||.||.||...|         .|      .|:|....||  |||              :.:..
Zfish   316 FLNRAFRRAFLMIL---------CC------GDERYARQGGFSPSR--------------QCSES 351

  Fly   469 VNSTASSEIHMSVMRARQYAVN 490
            ||.|:.| :.:|.:::|:|:.|
Zfish   352 VNGTSIS-LRLSFLQSRRYSDN 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_001262843.1	7tm_4	112..>231	CDD:304433	60/120 (50%)
Octbeta1R	NP_001262843.1	7tm_1	124..404	CDD:278431	113/286 (40%)
si:dkey-247m21.3	XP_017208337.2	7tmA_5-HT4	23..325	CDD:320184	123/314 (39%)
		TM helix 1	24..50	CDD:320184	9/26 (35%)
		TM helix 2	58..84	CDD:320184	15/25 (60%)
		TM helix 3	96..126	CDD:320184	18/29 (62%)
		TM helix 4	139..162	CDD:320184	11/22 (50%)
		TM helix 5	191..220	CDD:320184	12/28 (43%)
		TM helix 6	254..284	CDD:320184	14/29 (48%)
		TM helix 7	293..318	CDD:320184	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328277at33208
OrthoFinder	1	1.000	-	-		FOG0005484
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920