DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta1R and Drd5

DIOPT Version :9

Sequence 1:	NP_001262843.1	Gene:	Octbeta1R / 42652	FlyBaseID:	FBgn0038980	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_036900.1	Gene:	Drd5 / 25195	RGDID:	2523	Length:	475	Species:	Rattus norvegicus

Alignment Length:	377	Identity:	132/377 - (35%)
Similarity:	199/377 - (52%)	Gaps:	48/377 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 QAQDIQASEGSTDDADGSSHLALVFVKCFIIGFIILAAILGNMLVIVSVMRHRKLRI-ITNYFVV 147
            |...:.|..||.... |.:.:    |...::..:|:..:|||:||..:::|.|.||. :||.|:|
  Rat    20 QLAQVDAPAGSATPL-GPAQV----VTAGLLTLLIVWTLLGNVLVCAAIVRSRHLRAKMTNIFIV 79

  Fly   148 SLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQP 212
            ||||:|:.|||..|.:.|...::|.|.||: .||:|.:||:..|||||::||.||||||:||.:|
  Rat    80 SLAVSDLFVALLVMPWKAVAEVAGYWPFGT-FCDIWVAFDIMCSTASILNLCIISVDRYWAISRP 143

  Fly   213 LDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWY----------------TTTENYKYLKSNP 261
            ..|...||||...:|:.:.|....|:||:|:...|:                |..|....|:...
  Rat   144 FRYERKMTQRVALVMVGLAWTLSILISFIPVQLNWHRDKAGSQGQEGLLSNGTPWEEGWELEGRT 208

  Fly   262 HICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQISQIP 326
            ..|:..:|:.|||.||.:||:||..:|:..|.|||:.|..|.|.:..       ||:..:.:|..
  Rat   209 ENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISS-------LERAAEHAQSC 266

  Fly   327 KPRPSIQVEQSTISTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDS-----------CI 380
            :.|.:.:.:.|..:::::|.|..:||.:||..|:.||||||:...:...|.|           |:
  Rat   267 RSRGAYEPDPSLRASIKKETKVFKTLSMIMGVFVCCWLPFFILNCMVPFCSSGDAEGPKTGFPCV 331

  Fly   381 TPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKTLKSLFPYAFYFCRR 432
            : .....|..|.|:.||:||||||| ||.|||..|.:.|.     ..:||.|
  Rat   332 S-ETTFDIFVWFGWANSSLNPIIYA-FNADFRKVFAQLLG-----CSHFCFR 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_001262843.1	7tm_4	112..>231	CDD:304433	55/119 (46%)
Octbeta1R	NP_001262843.1	7tm_1	124..404	CDD:278431	111/307 (36%)
Drd5	NP_036900.1	7tm_1	55..354	CDD:278431	111/307 (36%)
		7tm_4	<121..>173	CDD:304433	26/51 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.970