DRSC/TRiP Functional Genomics Resources

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Protein Alignment Octbeta1R and Htr1a

DIOPT Version :10

Sequence 1:NP_651057.1 Gene:Octbeta1R / 42652 FlyBaseID:FBgn0038980 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_036717.2 Gene:Htr1a / 24473 RGDID:2845 Length:422 Species:Rattus norvegicus


Alignment Length:429 Identity:134/429 - (31%)
Similarity:200/429 - (46%) Gaps:92/429 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 GQAQDIQASE---GSTDDADGSSHLALVF--VKCFIIGFIILAAILGNMLVIVSVMRHRKLRIIT 142
            ||..:..||:   |:..:....|.:...:  :...::|.:|..|:|||..|:.::...|.|:.:.
  Rat     7 GQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVA 71

  Fly   143 NYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYY 207
            ||.:.||||.|::|::..:...|...:..||..|.|.||::.:.||...|:||:|||.|::|||:
  Rat    72 NYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYW 136

  Fly   208 AIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHICEFKVNKAY 272
            ||..|:||....|.||...::.:.||...|:|..|:. ||.|..:     :|:|..|....:..|
  Rat   137 AITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPML-GWRTPED-----RSDPDACTISKDHGY 195

  Fly   273 AIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQISQIPKPRPSIQ---- 333
            .|.|:..:|:||.::||.:|.||::.|..:.|...| ||........|..|..|.|:.|:.    
  Rat   196 TIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVR-KVEKKGAGTSLGTSSAPPPKKSLNGQPG 259

  Fly   334 -------VEQSTIST-------------------------------------------------- 341
                   .|...:.|                                                  
  Rat   260 SGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERK 324

  Fly   342 ------------MRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCD-SCITPRLLVGILFWIG 393
                        :.||||..:||||||..|::||||||:..:|...|: ||..|.||..|:.|:|
  Rat   325 NERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCENSCHMPALLGAIINWLG 389

  Fly   394 YFNSALNPIIYAYFNRDFRAAFKKTLKSLFPYAFYFCRR 432
            |.||.|||:||||||:||:.||||.:|.      .||||
  Rat   390 YSNSLLNPVIYAYFNKDFQNAFKKIIKC------KFCRR 422

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Octbeta1RNP_651057.1 7tmA_DmOct-betaAR-like 109..415 CDD:320194 119/379 (31%)
TM helix 1 109..135 CDD:320194 7/25 (28%)
TM helix 2 142..168 CDD:320194 9/25 (36%)
TM helix 3 180..210 CDD:320194 15/29 (52%)
TM helix 4 222..245 CDD:320194 7/22 (32%)
TM helix 5 269..298 CDD:320194 11/28 (39%)
TM helix 6 343..373 CDD:320194 17/29 (59%)
TM helix 7 383..408 CDD:320194 15/24 (63%)
Htr1aNP_036717.2 7tmA_5-HT1A_vertebrates 37..411 CDD:320453 119/380 (31%)
TM helix 1 38..64 CDD:320453 7/25 (28%)
TM helix 2 71..97 CDD:320453 9/25 (36%)
TM helix 3 109..139 CDD:320453 15/29 (52%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 133..135 1/1 (100%)
TM helix 4 151..173 CDD:320453 7/21 (33%)
TM helix 5 192..221 CDD:320453 11/28 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 235..261 5/25 (20%)
TM helix 6 338..368 CDD:320453 17/29 (59%)
TM helix 7 379..404 CDD:320453 15/24 (63%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 396..400 2/3 (67%)

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