Protein Alignment Octbeta1R and GPR161

DIOPT Version :10

• Sequence 1: NP_651057.1
• Gene: Octbeta1R / 42652
• FlyBaseID: FBgn0038980
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001254538.1
• Gene: GPR161 / 23432
• HGNCID: 23694
• Length: 549
• Species: Homo sapiens
• Alignment Length: 375
• Identity: 91/375 - (24%)
• Similarity: 177/375 - (47%)
• Gaps: 56/375 - (14%)

  Fly    84 QAQDIQASEGSTDDADGSSHLALVFVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVS 148
            :..::...||.......:..:|::.:..|:        .|||::::|::.:...|..::|.||.|
Human    32 ELSNLTEEEGGEGGVIITQFIAIIVITIFV--------CLGNLVIVVTLYKKSYLLTLSNKFVFS 88

  Fly   149 LAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPL 213
            |.:::.|:::..:.|..:..|..:|:||.|.|:......:..|:||::.|..|::|||||::.|:
Human    89 LTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPM 153

  Fly   214 DYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHICEFK--VNKAYAIVS 276
            .||:.:|..|..:.|:.:||. :|:..||...||           |:....|||  ...|:....
Human   154 VYPMKITGNRAVMALVYIWLH-SLIGCLPPLFGW-----------SSVEFDEFKWMCVAAWHREP 206

  Fly   277 SSMSFW------IPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQISQIPKPRPSIQVE 335
            ...:||      .|.:|||..|..|::.|..:.|.|:...|  :::|:..|.:    .|.:....
Human   207 GYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTV--VIVEEDAQRT----GRKNSSTS 265

  Fly   336 QSTISTMR----------RERKAARTLGIIMSAFLICWLPFFLWYIVSSLC---DSCITPRLLVG 387
            .|:..:.|          .:.||..|:.:::.||::.|.|:.:  :::|..   .|.::|.|...
Human   266 TSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMV--VIASEALWGKSSVSPSLETW 328

  Fly   388 ILFWIGYFNSALNPIIYAYFNRDFRAAFKKTLKSLFPYAFY---FCRRGR 434
            .. |:.:.::..:|:||..:|:..|   |:.|...|...:|   |.:|.|
Human   329 AT-WLSFASAVCHPLIYGLWNKTVR---KELLGMCFGDRYYREPFVQRQR 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_651057.1	7tmA_DmOct-betaAR-like	109..415	CDD:320194	81/326 (25%)
		TM helix 1	109..135	CDD:320194	5/25 (20%)
		TM helix 2	142..168	CDD:320194	7/25 (28%)
		TM helix 3	180..210	CDD:320194	11/29 (38%)
		TM helix 4	222..245	CDD:320194	7/22 (32%)
		TM helix 5	269..298	CDD:320194	9/34 (26%)
		TM helix 6	343..373	CDD:320194	8/39 (21%)
		TM helix 7	383..408	CDD:320194	5/24 (21%)
GPR161	NP_001254538.1	7tmA_GPR161	49..355	CDD:320342	83/337 (25%)
		TM helix 1	49..75	CDD:320342	6/33 (18%)
		TM helix 2	82..107	CDD:320342	7/24 (29%)
		TM helix 3	120..150	CDD:320342	11/29 (38%)
		TM helix 4	162..184	CDD:320342	7/22 (32%)
		TM helix 5	205..234	CDD:320342	8/28 (29%)
		TM helix 6	283..313	CDD:320342	7/31 (23%)
		TM helix 7	323..348	CDD:320342	6/25 (24%)