Protein Alignment Octbeta1R and Chrm5

DIOPT Version :10

• Sequence 1: NP_651057.1
• Gene: Octbeta1R / 42652
• FlyBaseID: FBgn0038980
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_991352.2
• Gene: Chrm5 / 213788
• MGIID: 109248
• Length: 532
• Species: Mus musculus
• Alignment Length: 532
• Identity: 121/532 - (22%)
• Similarity: 194/532 - (36%)
• Gaps: 203/532 - (38%)

  Fly   102 SHLAL-------VFVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALC 159
            :|.||       |.....:...:.|..|:||:||::|...:.:|:.:.||:::|||.||:::.:.
Mouse    18 NHQALERHGLWEVITIAAVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIF 82

  Fly   160 AMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRV 224
            :|....:.::.|:|:.||:.||:|.:.|...|.||:|:|..||.|||::|.:||.|....|.:|.
Mouse    83 SMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRA 147

  Fly   225 FIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSN----PHIC--EFKVNKAYAIVSSSMSFWI 283
            .||:.:.||...:|        |......::||...    |..|  :|.........::..:|:|
Mouse   148 GIMIGLAWLVSFIL--------WAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYI 204

  Fly   284 PGIVMLSMYYRIYQEADRQER----LVYRSKVAALLLEK--H--LQISQIPKPRPSIQV---EQS 337
            |..||..:|.|||:|.:::.:    |.....||.:...|  |  |..|....||||:..   .|:
Mouse   205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEVKKRKPAHRTLLRSFFSCPRPSLAQRVRNQA 269

  Fly   338 TISTMRR---------------------------------------------------------- 344
            :.|:.||
Mouse   270 SWSSSRRSTSTTGKPTQATDLSADWEKAEQVTNCSSCPSSEDEAKATTDPVFQVVCKNEAKESPG 334

  Fly   345 ----------------------------------------------------------------- 344
                                                                             
Mouse   335 KEFNTQETKETFVSPRTENNDYDTPKYFLSPGAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRK 399

  Fly   345 -------------------------------------ERKAARTLGIIMSAFLICWLPFFLWYIV 372
                                                 |||||:||..|:.||:|.|.|:.:..:|
Mouse   400 VKIMPCSFPVSKDPSTKGLDPHLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLV 464

  Fly   373 SSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKTLKSLFPYAFYFCRRGRGRD 437
            |:.||.|: |..|..:.:|:.|.||.:|||.||..||.||..||..|         .||..:.:.
Mouse   465 STFCDKCV-PVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLL---------LCRWKKKKV 519

  Fly   438 DDRDLEFGGPSR 449
            ::: |.:.|.|:
Mouse   520 EEK-LYWQGNSK 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_651057.1	7tmA_DmOct-betaAR-like	109..415	CDD:320194	109/482 (23%)
		TM helix 1	109..135	CDD:320194	7/25 (28%)
		TM helix 2	142..168	CDD:320194	8/25 (32%)
		TM helix 3	180..210	CDD:320194	14/29 (48%)
		TM helix 4	222..245	CDD:320194	6/22 (27%)
		TM helix 5	269..298	CDD:320194	9/28 (32%)
		TM helix 6	343..373	CDD:320194	15/189 (8%)
		TM helix 7	383..408	CDD:320194	10/24 (42%)
Chrm5	NP_991352.2	7tmA_mAChR_M5	31..>225	CDD:320427	61/201 (30%)
		TM helix 1	32..58	CDD:320427	7/25 (28%)
		TM helix 2	65..91	CDD:320427	8/25 (32%)
		TM helix 3	103..133	CDD:320427	14/29 (48%)
		TM helix 4	145..168	CDD:320427	7/30 (23%)
		TM helix 5	190..219	CDD:320427	9/28 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	265..290		4/24 (17%)
		7tm_GPCRs	<435..514	CDD:475119	37/88 (42%)
		TM helix 6	441..463	CDD:410628	9/21 (43%)
		TM helix 7	474..499	CDD:410628	10/24 (42%)