Protein Alignment Octbeta1R and dop-3

DIOPT Version :10

• Sequence 1: NP_651057.1
• Gene: Octbeta1R / 42652
• FlyBaseID: FBgn0038980
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001024908.2
• Gene: dop-3 / 188499
• WormBaseID: WBGene00020506
• Length: 607
• Species: Caenorhabditis elegans
• Alignment Length: 574
• Identity: 118/574 - (20%)
• Similarity: 178/574 - (31%)
• Gaps: 284/574 - (49%)

  Fly   121 AILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISG-KWMFGSVMCDMWN 184
            |:.||:|||:||.|.|.|:.:||..:|||||:|.:||:..|:|......:. ||..||..|.::.
 Worm    35 AVFGNVLVIMSVFRERSLQTVTNMLIVSLAVSDFMVAIGVMSFGVYYEWNDFKWGLGSFFCHVYQ 99

  Fly   185 SFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQ-RRVFIMLLMVW-LSPALLSFLPICSGW 247
            :.||..|||||::|..||:|||.||..|:.|.....: .|..|.:.:|| :|.|:.  ||:..|.
 Worm   100 ALDVACSTASILNLLAISLDRYIAIGHPISYAQYGARGGRAMISITIVWGVSVAVA--LPLLLGV 162

  Fly   248 YTTTENYKYLKSNPHICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERL------- 305
            ....||      :...||. .|..:.::||..||:||.|.|:.:|..|::...::||.
 Worm   163 NPMEEN------DLQECEL-ANPYFNMISSIFSFFIPCIAMIILYTIIFRRLRQRERARSLRQAQ 220

  Fly   306 -----------------------VYRSKVAALLLEKHLQISQIP--------------------- 326
                                   .::::...:|||...|.|..|
 Worm   221 RSENDKISSALLGGAQIARQMGKHFKNRTDQILLEISFQTSSFPTMSESSEDASTISPMINSFNN 285

  Fly   327 ----------------------------------------------------------------- 326
                                                                             
 Worm   286 FLPKKTPYPSTSIPAIPECGSMPNLTIIERPEAEKEKEISIMDLRDTVEMLDDKYSSAILTSFQT 350

  Fly   327 ----------------------------------------------------------------- 326
                                                                             
 Worm   351 SRSFGEELEEILPFIDGSNSVKHSREQLHTTRSNTSTTRLLDVKPELRSISVPSIQDEKKLSQKS 415

  Fly   327 ----------------------------------------------------------------- 326
                                                                             
 Worm   416 NDLPFSHQNGTHKQKLLPNPGILMKSKSTTLLKTNGYMDTDSLNRNSHKKSLADLLANDEFSFSD 480

  Fly   327 ---------------------KPRPSIQVEQSTISTMRRERKAARTLGIIMSAFLICWLPFFLWY 370
                                 |||||..:.:.....||||.||..||.::::.||.||||||:.:
 Worm   481 SMRVYKNRLFKSLSRATSGWNKPRPSRHMVKKATKQMRREHKATVTLAVVLAVFLFCWLPFFVLH 545

  Fly   371 IVSSLC-----DSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKTL 419
            :.:|:|     :|.....|.:.:..|:||.||:|||:||..|::.||.||:..|
 Worm   546 LSNSICLIIDENSACVGFLPLYLATWLGYLNSSLNPLIYTVFDQRFRNAFRNIL 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_651057.1	7tmA_DmOct-betaAR-like	109..415	CDD:320194	115/568 (20%)
		TM helix 1	109..135	CDD:320194	8/13 (62%)
		TM helix 2	142..168	CDD:320194	12/25 (48%)
		TM helix 3	180..210	CDD:320194	15/29 (52%)
		TM helix 4	222..245	CDD:320194	8/23 (35%)
		TM helix 5	269..298	CDD:320194	11/28 (39%)
		TM helix 6	343..373	CDD:320194	15/29 (52%)
		TM helix 7	383..408	CDD:320194	11/24 (46%)
dop-3	NP_001024908.2	7tmA_D2-like_dopamine_R	22..>204	CDD:320181	68/177 (38%)
		TM helix 1	23..49	CDD:320181	8/13 (62%)
		TM helix 2	56..82	CDD:320181	12/25 (48%)
		TM helix 3	95..125	CDD:320181	15/29 (52%)
		TM helix 4	138..161	CDD:320181	8/24 (33%)
		TM helix 5	177..204	CDD:320181	10/26 (38%)
		7tm_GPCRs	<515..595	CDD:475119	33/79 (42%)
		TM helix 6	524..546	CDD:410628	10/21 (48%)
		TM helix 7	563..588	CDD:410628	11/24 (46%)