DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Octbeta1R and DRD1

DIOPT Version :9

Sequence 1:	NP_001262843.1	Gene:	Octbeta1R / 42652	FlyBaseID:	FBgn0038980	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_000785.1	Gene:	DRD1 / 1812	HGNCID:	3020	Length:	446	Species:	Homo sapiens

Alignment Length:	428	Identity:	145/428 - (33%)
Similarity:	219/428 - (51%)	Gaps:	36/428 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 VFVKCFIIGFIILAAILGNMLVIVSVMRHRKLRI-ITNYFVVSLAVADMLVALCAMTFNASVMIS 170
            :...|| :..:||:.:|||.||..:|:|.|.||. :||:||:||||:|:|||:..|.:.|...|:
Human    24 ILTACF-LSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIA 87

  Fly   171 GKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSP 235
            |.|.||| .|::|.:||:..|||||::||.||||||:||..|..|...||.:..||::.:.|...
Human    88 GFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLS 151

  Fly   236 ALLSFLPICSGWY------TTTENYKYLKSNPHICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYR 294
            .|:||:|:...|:      .:..|...|......|:..:::.|||.||.:||:||..:|:..|.|
Human   152 VLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTR 216

  Fly   295 IYQEADRQERLVYRSKVAALLLEKHLQISQIPKPRPSIQVEQSTISTMRRERKAARTLGIIMSAF 359
            ||:.|.:|.|.:...:.||:..:.....:...||....|.|.|...:.:||.|..:||.:||..|
Human   217 IYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVF 281

  Fly   360 LICWLPFFLWYIVSSLCDS------CITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKT 418
            :.||||||:...:...|.|      ||..... .:..|.|:.||:||||||| ||.|||.||...
Human   282 VCCWLPFFILNCILPFCGSGETQPFCIDSNTF-DVFVWFGWANSSLNPIIYA-FNADFRKAFSTL 344

  Fly   419 LKSLFPYAFYFCRRGRGRDDDRDLEFGGPSRRGTNGAQRTGSGSAE------MANCVNSTASSEI 477
            |.     .:..|.......:...:...|.:...::...| ||.|.|      :.:.|.|:...:.
Human   345 LG-----CYRLCPATNNAIETVSINNNGAAMFSSHHEPR-GSISKECNLVYLIPHAVGSSEDLKK 403

  Fly   478 HMSVMRAR-------QYAVNVTPTTDAQMQQLHPLYTN 508
            ..:...||       ..:|.:...||..::::.|:..|
Human   404 EEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQN 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_001262843.1	7tm_4	112..>231	CDD:304433	58/119 (49%)
Octbeta1R	NP_001262843.1	7tm_1	124..404	CDD:278431	113/292 (39%)
DRD1	NP_000785.1	7tmA_D1A_dopamine_R	23..341	CDD:320443	126/320 (39%)
		TM helix 1	26..50	CDD:320443	10/24 (42%)
		TM helix 2	60..82	CDD:320443	12/21 (57%)
		TM helix 3	97..119	CDD:320443	11/21 (52%)
		TM helix 4	142..158	CDD:320443	5/15 (33%)
		TM helix 5	192..215	CDD:320443	10/22 (45%)
		TM helix 6	271..293	CDD:320443	11/21 (52%)
		TM helix 7	310..335	CDD:320443	12/26 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.970