DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta1R and Htr4

DIOPT Version :9

Sequence 1:	NP_001262843.1	Gene:	Octbeta1R / 42652	FlyBaseID:	FBgn0038980	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_032339.2	Gene:	Htr4 / 15562	MGIID:	109246	Length:	388	Species:	Mus musculus

Alignment Length:	331	Identity:	141/331 - (42%)
Similarity:	190/331 - (57%)	Gaps:	24/331 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 DADGSSHLALVFV-KCFIIGF---IILAAILGNMLVIVSVMRHRKLR-IITNYFVVSLAVADMLV 156
            ||:.||:.....| |..::.|   :||.|||||:||:|:|.|.|:|| |.||||:||||.||:||
Mouse     5 DANVSSNEGFRSVEKVVLLTFLAVVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLV 69

  Fly   157 ALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAI-VQPLDYPLIMT 220
            ::..|.|.|..::...|.:|.:.|.:..|.||..:||||.||||||:|||||| .|||.|...||
Mouse    70 SVLVMPFGAIELVQDIWAYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134

  Fly   221 QRRVFIMLLMVWLSPALLSFLPICSGW-----YTTTENYKYL-KSNPHICEFKVNKAYAIVSSSM 279
            ..|:.:||...|:.|..:|||||..||     ....|..|:. .||...|.|.|||.|||..|.:
Mouse   135 PLRIALMLGGCWVLPMFISFLPIMQGWNNIGIVDVIEKRKFSHNSNSTWCVFMVNKPYAITCSVV 199

  Fly   280 SFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQISQIPKPRPSIQVEQSTISTMRR 344
            :|:||.::|:..|||||..|....:.:...:.|....|.        :|:|:   :|.:...||.
Mouse   200 AFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSES--------RPQPA---DQHSTHRMRT 253

  Fly   345 ERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNR 409
            |.|||:||.:||..|..||.|||:..||....|..:..::....| |:||.||.|||.:||:.|:
Mouse   254 ETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEQVWTAFL-WLGYINSGLNPFLYAFLNK 317

  Fly   410 DFRAAF 415
            .||.||
Mouse   318 SFRRAF 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_001262843.1	7tm_4	112..>231	CDD:304433	63/123 (51%)
Octbeta1R	NP_001262843.1	7tm_1	124..404	CDD:278431	122/287 (43%)
Htr4	NP_032339.2	7tmA_5-HT4	20..323	CDD:320184	133/314 (42%)
		TM helix 1	21..47	CDD:320184	12/25 (48%)
		TM helix 2	55..81	CDD:320184	15/25 (60%)
		TM helix 3	93..123	CDD:320184	19/29 (66%)
		TM helix 4	136..159	CDD:320184	10/22 (45%)
		TM helix 5	189..218	CDD:320184	15/28 (54%)
		TM helix 6	252..282	CDD:320184	16/29 (55%)
		TM helix 7	291..316	CDD:320184	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20243
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005484
OrthoInspector	1	1.000	-	-		otm42843
orthoMCL	1	0.900	-	-		OOG6_107218
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4996
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.840