Protein Alignment Octbeta1R and TAAR1

DIOPT Version :10

• Sequence 1: NP_651057.1
• Gene: Octbeta1R / 42652
• FlyBaseID: FBgn0038980
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_612200.1
• Gene: TAAR1 / 134864
• HGNCID: 17734
• Length: 339
• Species: Homo sapiens
• Alignment Length: 355
• Identity: 115/355 - (32%)
• Similarity: 171/355 - (48%)
• Gaps: 54/355 - (15%)

  Fly    75 VSVEDVVAGQAQDIQASEGSTDDADGSSHLALVFVKCFIIGFIILAAILGNMLVIVSVMRHRKLR 139
            :::..|....:.|::||..|                  ::..|||..::||::||||:...::|.
Human     9 INISCVKNNWSNDVRASLYS------------------LMVLIILTTLVGNLIVIVSISHFKQLH 55

  Fly   140 IITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVD 204
            ..||:.:.|:|..|.|:....|.::........|.||.|.|.:..|.|:..|:|||.||..||:|
Human    56 TPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID 120

  Fly   205 RYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYK-----YLKSNPHI- 263
            ||||:..||.|...|....:.:|:.:.|..||:.:|     |......|:|     |.|   |:
Human   121 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAF-----GMIFLELNFKGAEEIYYK---HVH 177

  Fly   264 ----CEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQISQ 324
                |....:|...:::...||:|||.:||.:|||||..|..|.||:..:       .:.|||.
Human   178 CRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDA-------NQKLQIG- 234

  Fly   325 IPKPRPSIQVEQSTISTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGIL 389
                     :|.....:..:||||.:||||:|..|||||.|||:..::.......|.| .|..:|
Human   235 ---------LEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPP-TLNDVL 289

  Fly   390 FWIGYFNSALNPIIYAYFNRDFRAAFKKTL 419
            .|.||.||..||::||:|...||.|.|..|
Human   290 IWFGYLNSTFNPMVYAFFYPWFRKALKMML 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_651057.1	7tmA_DmOct-betaAR-like	109..415	CDD:320194	107/315 (34%)
		TM helix 1	109..135	CDD:320194	9/25 (36%)
		TM helix 2	142..168	CDD:320194	7/25 (28%)
		TM helix 3	180..210	CDD:320194	16/29 (55%)
		TM helix 4	222..245	CDD:320194	5/22 (23%)
		TM helix 5	269..298	CDD:320194	13/28 (46%)
		TM helix 6	343..373	CDD:320194	17/29 (59%)
		TM helix 7	383..408	CDD:320194	11/24 (46%)
TAAR1	NP_612200.1	7tmA_TAAR1	26..315	CDD:320438	108/332 (33%)
		TM helix 1	26..51	CDD:320438	10/42 (24%)
		TM helix 2	58..84	CDD:320438	7/25 (28%)
		TM helix 3	96..126	CDD:320438	16/29 (55%)
		TM helix 4	138..161	CDD:320438	6/27 (22%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465	175..186		2/10 (20%)
		TM helix 5	187..216	CDD:320438	13/28 (46%)
		TM helix 6	244..274	CDD:320438	17/29 (59%)
		TM helix 7	283..308	CDD:320438	12/25 (48%)