Protein Alignment Octbeta1R and Chrm1

DIOPT Version :10

• Sequence 1: NP_651057.1
• Gene: Octbeta1R / 42652
• FlyBaseID: FBgn0038980
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_031724.2
• Gene: Chrm1 / 12669
• MGIID: 88396
• Length: 460
• Species: Mus musculus
• Alignment Length: 434
• Identity: 111/434 - (25%)
• Similarity: 186/434 - (42%)
• Gaps: 137/434 - (31%)

  Fly   115 GFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVM 179
            |.:.||.:.||:||::|...:.:|:.:.|||::|||.||:::...:|....:.::.|.|..|::.
Mouse    33 GLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLA 97

  Fly   180 CDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWL------SPALL 238
            ||:|.:.|...|.||:|:|..||.|||:::.:||.|....|.||..:|:.:.||      :||:|
Mouse    98 CDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAIL 162

  Fly   239 SFLPICSGWYTTTENYKYLK--SNPHICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADR 301
             |.....|..|......|::  |.|.|         ...::..:|::|..||.::|:|||:|.:.
Mouse   163 -FWQYLVGERTVLAGQCYIQFLSQPII---------TFGTAMAAFYLPVTVMCTLYWRIYRETEN 217

  Fly   302 QERLVYRSKVAAL------------------------------------------LLEKH----- 319
            :.|     ::|||                                          ||:.:
Mouse   218 RAR-----ELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEE 277

  Fly   320 ----------LQISQIPKP----------------RPSIQVEQSTISTMRR-------------- 344
                      |..|:..:|                .|:.|..:|:.:|::|
Mouse   278 EEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQK 342

  Fly   345 -----------------ERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWI 392
                             |:||||||..|:.||::.|.|:.:..:||:.|..|: |..|..:.:|:
Mouse   343 PRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCV-PETLWELGYWL 406

  Fly   393 GYFNSALNPIIYAYFNRDFRAAFKKTLKSLFPYAFYFCRRGRGR 436
            .|.||.:||:.||..|:.||..|:..|         .||..:.|
Mouse   407 CYVNSTVNPMCYALCNKAFRDTFRLLL---------LCRWDKRR 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_651057.1	7tmA_DmOct-betaAR-like	109..415	CDD:320194	106/411 (26%)
		TM helix 1	109..135	CDD:320194	8/19 (42%)
		TM helix 2	142..168	CDD:320194	9/25 (36%)
		TM helix 3	180..210	CDD:320194	14/29 (48%)
		TM helix 4	222..245	CDD:320194	9/28 (32%)
		TM helix 5	269..298	CDD:320194	8/28 (29%)
		TM helix 6	343..373	CDD:320194	13/60 (22%)
		TM helix 7	383..408	CDD:320194	9/24 (38%)
Chrm1	NP_031724.2	7tmA_mAChR_M1	26..429	CDD:341356	106/411 (26%)
		TM helix 1	27..53	CDD:341356	8/19 (42%)
		TM helix 2	60..86	CDD:341356	9/25 (36%)
		TM helix 3	98..128	CDD:341356	14/29 (48%)
		TM helix 4	140..163	CDD:341356	8/23 (35%)
		TM helix 5	185..214	CDD:341356	10/37 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..257		1/31 (3%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..297		2/22 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	310..351		5/40 (13%)
		TM helix 6	358..388	CDD:341356	12/29 (41%)
		TM helix 7	397..422	CDD:341356	9/24 (38%)