DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Octbeta1R and Adrb3

DIOPT Version :9

Sequence 1:	NP_001262843.1	Gene:	Octbeta1R / 42652	FlyBaseID:	FBgn0038980	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_038490.2	Gene:	Adrb3 / 11556	MGIID:	87939	Length:	400	Species:	Mus musculus

Alignment Length:	348	Identity:	130/348 - (37%)
Similarity:	191/348 - (54%)	Gaps:	38/348 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 IILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCD 181
            :.||.:.||:|||:::.|..:|:.|||.||.|||.||::|.|..|...|::.::|.|..|...|:
Mouse    44 LALATVGGNLLVIIAIARTPRLQTITNVFVTSLAAADLVVGLLVMPPGATLALTGHWPLGETGCE 108

  Fly   182 MWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSG 246
            :|.|.||...||||..||.::||||.|:..||.|..::|:||....:::||:..|.:||.||.|.
Mouse   109 LWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSAAVSFAPIMSQ 173

  Fly   247 WYTTTENYKYLK--SNPHICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRS 309
            |:....:.:..:  |||..|.|..|..||::|||:||::|.:|||.:|.|::..|.||..|: |.
Mouse   174 WWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRHLL-RR 237

  Fly   310 KVAALLLEKHLQISQIPKPRPSIQVEQSTISTMR------------------RERKAARTLGIIM 356
            ::.....|:       ..|.||.....:|..|..                  ||.:|.||||:||
Mouse   238 ELGRFSPEE-------SPPSPSRSPSPATGGTPAAPDGVPPCGRRPARLLPLREHRALRTLGLIM 295

  Fly   357 SAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKTLKS 421
            ..|.:|||||||..::.:|....:.|..:...|.|:||.|||.||:||.. :.|||.||::.|.|
Mouse   296 GIFSLCWLPFFLANVLRALAGPSLVPSGVFIALNWLGYANSAFNPVIYCR-SPDFRDAFRRLLCS 359

  Fly   422 LFPYAFYFCRRGRGRDDDRDLEF 444
               |.      |||.::.|.:.|
Mouse   360 ---YG------GRGPEEPRAVTF 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_001262843.1	7tm_4	112..>231	CDD:304433	48/113 (42%)
Octbeta1R	NP_001262843.1	7tm_1	124..404	CDD:278431	113/299 (38%)
Adrb3	NP_038490.2	7tm_GPCRs	48..353	CDD:391938	118/313 (38%)
		TM helix 2	70..92	CDD:341315	11/21 (52%)
		TM helix 3	108..130	CDD:341315	10/21 (48%)
		TM helix 4	153..169	CDD:341315	5/15 (33%)
		TM helix 5	199..222	CDD:341315	11/22 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	241..271		6/36 (17%)
		TM helix 6	285..310	CDD:341315	15/24 (63%)
		TM helix 7	322..347	CDD:341315	11/25 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..400		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	228	1.000	Domainoid score	I2479
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8780
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X822
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010