Protein Alignment Octbeta1R and chrm5

DIOPT Version :10

• Sequence 1: NP_651057.1
• Gene: Octbeta1R / 42652
• FlyBaseID: FBgn0038980
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: XP_017952476.1
• Gene: chrm5 / 100498518
• XenbaseID: XB-GENE-986590
• Length: 525
• Species: Xenopus tropicalis
• Alignment Length: 477
• Identity: 106/477 - (22%)
• Similarity: 172/477 - (36%)
• Gaps: 179/477 - (37%)

  Fly   113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGS 177
            :...:.|..|:||:||:||...:.:|:.:.||:::|||.||:::.:.:|....|.::.|.|..||
 Frog    31 VSAIVSLITIVGNILVMVSFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILIGHWSLGS 95

  Fly   178 VMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWL------SPA 236
            :.||:|.:.|...|.||:|:|..||.|||::|.:||.|....|.:|..:|:.:.|.      :||
 Frog    96 LACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGLMIGLAWFISFILWAPA 160

  Fly   237 LLSFLPICSGWYTTTENYKYLKSNPHICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEAD- 300
            :|.:.....|.....|..:        .:|.........::..:|::|..||..:|.|||:|.:
 Frog   161 ILCWQYFVGGRTVPPEECQ--------IQFLYEPIITFGTAIAAFYLPVSVMTILYCRIYKETEK 217

  Fly   301 ---------------------------------------RQERL--------------------- 305
                                                   ::||.
 Frog   218 RTKDLAELQGSESVADFEMMRPQGTLFKSCFSCKQQTRTKRERCQASWSSSSRSTTTTVKITHSP 282

  Fly   306 -----------------------------------VYRSKVAALLLEKHLQI------------- 322
                                               .|.::..|...|:..||
 Frog   283 NTCNEWIKEDQLTTCSSYPSSDDEDKQTKEAVFQGAYENQTEAQKEEETKQILTKEQPGLSNYES 347

  Fly   323 ------------SQIPK-------------------------------------------PRPSI 332
                        .:.||                                           |..|.
 Frog   348 ERFFLTPGKGHSQKSPKCVSYKFRIVVNDDGSQEVNNGCRKVKITPCSSMSKGHSLRSMDPSISH 412

  Fly   333 QVEQSTISTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNS 397
            |:.:.....:.:|||||:||..|:.||:|.|.|:.:..:||:.|..|| |..|..:.:|:.|.||
 Frog   413 QITKRKRMVLIKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCSDCI-PSSLWHLGYWLCYVNS 476

  Fly   398 ALNPIIYAYFNRDFRAAFKKTL 419
            .:|||.||..|:.||..||..|
 Frog   477 TVNPICYALCNKTFRKTFKMLL 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_651057.1	7tmA_DmOct-betaAR-like	109..415	CDD:320194	103/471 (22%)
		TM helix 1	109..135	CDD:320194	8/21 (38%)
		TM helix 2	142..168	CDD:320194	9/25 (36%)
		TM helix 3	180..210	CDD:320194	14/29 (48%)
		TM helix 4	222..245	CDD:320194	6/28 (21%)
		TM helix 5	269..298	CDD:320194	8/28 (29%)
		TM helix 6	343..373	CDD:320194	13/29 (45%)
		TM helix 7	383..408	CDD:320194	10/24 (42%)
chrm5	XP_017952476.1	7tm_GPCRs	26..>220	CDD:475119	59/196 (30%)
		TM helix 1	28..52	CDD:320427	8/20 (40%)
		TM helix 2	61..83	CDD:320427	8/21 (38%)
		TM helix 3	99..121	CDD:320427	9/21 (43%)
		TM helix 4	144..160	CDD:320427	2/15 (13%)
		TM helix 5	186..209	CDD:320427	4/22 (18%)
		7tm_GPCRs	<423..502	CDD:475119	35/77 (45%)
		TM helix 6	429..451	CDD:320426	9/21 (43%)
		TM helix 7	462..487	CDD:320426	10/24 (42%)