DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta1R and htr4

DIOPT Version :9

Sequence 1:	NP_001262843.1	Gene:	Octbeta1R / 42652	FlyBaseID:	FBgn0038980	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_002939852.1	Gene:	htr4 / 100493952	XenbaseID:	XB-GENE-993770	Length:	386	Species:	Xenopus tropicalis

Alignment Length:	323	Identity:	141/323 - (43%)
Similarity:	187/323 - (57%)	Gaps:	29/323 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 VFVKCFIIGFI---ILAAILGNMLVIVSVMRHRKLR-IITNYFVVSLAVADMLVALCAMTFNASV 167
            |..:..:|.||   ||..||||:||:|:|.|.|:|| |.||||:||||.||:||::..|.|.|..
Frog    15 VAARIVLISFISAVILMTILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 79

  Fly   168 MISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAI-VQPLDYPLIMTQRRVFIMLLMV 231
            ::..||::|.:.|.:..|.||..:||||:||||||:|||||| .|||.|...||..|:.:||...
Frog    80 LVQEKWIYGEMFCLVRTSLDVLLTTASILHLCCISLDRYYAICCQPLVYRNKMTPLRITLMLSGC 144

  Fly   232 WLSPALLSFLPICSGWYT-----TTENYKYLK-SNPHICEFKVNKAYAIVSSSMSFWIPGIVMLS 290
            |:.|..:|||||..||.:     ..|..||.| ||...|.|.|||.|||..|.::|:||..:|:.
Frog   145 WIIPTFISFLPIMQGWNSIGILDLIETRKYNKSSNSTNCIFMVNKPYAITCSVVAFYIPFFLMVL 209

  Fly   291 MYYRIY---QEADRQERLVYRSKVAALLLEKHLQISQIPKPRPSIQVEQSTISTMRRERKAARTL 352
            .|||||   :|..||..::.|:...|....:|              .:|.|...|:.|.|||:||
Frog   210 AYYRIYITAREHARQIGVLQRAGAPADHRHQH--------------PDQHTTHRMKTETKAAKTL 260

  Fly   353 GIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAF 415
            .|||..|.:||.|||:..:|....:..:...|....| |:||.||.|||.:||:.|:.||.||
Frog   261 CIIMGCFCLCWAPFFITNVVDPFINYSVPVELWTAFL-WLGYINSGLNPFLYAFLNKSFRRAF 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_001262843.1	7tm_4	112..>231	CDD:304433	65/123 (53%)
Octbeta1R	NP_001262843.1	7tm_1	124..404	CDD:278431	126/290 (43%)
htr4	XP_002939852.1	7tmA_5-HT4	19..322	CDD:320184	138/317 (44%)
		TM helix 1	20..46	CDD:320184	13/25 (52%)
		TM helix 2	54..80	CDD:320184	15/25 (60%)
		TM helix 3	92..122	CDD:320184	19/29 (66%)
		TM helix 4	135..158	CDD:320184	10/22 (45%)
		TM helix 5	188..217	CDD:320184	15/28 (54%)
		TM helix 6	251..281	CDD:320184	15/29 (52%)
		TM helix 7	290..315	CDD:320184	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20243
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328277at33208
OrthoFinder	1	1.000	-	-		FOG0005484
OrthoInspector	1	1.000	-	-		mtm14086
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010