DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta1R and drd1

DIOPT Version :9

Sequence 1:	NP_001262843.1	Gene:	Octbeta1R / 42652	FlyBaseID:	FBgn0038980	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_017947694.2	Gene:	drd1 / 100485463	XenbaseID:	XB-GENE-6035431	Length:	451	Species:	Xenopus tropicalis

Alignment Length:	330	Identity:	134/330 - (40%)
Similarity:	192/330 - (58%)	Gaps:	21/330 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 VFVKCFIIGFIILAAILGNMLVIVSVMRHRKLRI-ITNYFVVSLAVADMLVALCAMTFNASVMIS 170
            |...|| :..:||:.:|||.||..:|:|.|.||. :||:||:||||:|:|||:..|.:.|...|:
Frog    23 VLTGCF-LSVLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIA 86

  Fly   171 GKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSP 235
            |.|.||: .|::|.:||:..|||||::||.||||||:||..|..|...||.:..|||:.:.|...
Frog    87 GFWPFGT-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLS 150

  Fly   236 ALLSFLPICSGWY-TTTENYKYLKSNPH-----ICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYR 294
            .|:||:|:...|: ..|.::..|....|     .|:..:|:.|||.||.:||:||..:|:..|.|
Frog   151 ILISFIPVQLNWHKAKTTSFFDLNITLHGRTMDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTR 215

  Fly   295 IYQEADRQERLVYRSKVAALLLEKHLQISQIPKPRPSIQVEQSTIST-MRRERKAARTLGIIMSA 358
            ||:.|.:|.|.:...:.|| :..|:.|.|...:.....|..:|::.| .:||.|..:||.:||..
Frog   216 IYRIAAKQIRRISALERAA-VHAKNCQNSTGNRNSLDCQQPESSLKTSFKRETKVLKTLSVIMGV 279

  Fly   359 FLICWLPFFLWYIVSSLCDSCIT-----PRLLVGILF----WIGYFNSALNPIIYAYFNRDFRAA 414
            |:.||||||:...:...||..:|     |..:....|    |.|:.||:||||||| ||.|||.|
Frog   280 FVCCWLPFFILNCIVPFCDPSLTTSGTEPFCISSTTFDVFVWFGWANSSLNPIIYA-FNADFRKA 343

  Fly   415 FKKTL 419
            |...|
Frog   344 FSNLL 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_001262843.1	7tm_4	112..>231	CDD:304433	58/119 (49%)
Octbeta1R	NP_001262843.1	7tm_1	124..404	CDD:278431	117/296 (40%)
drd1	XP_017947694.2	7tmA_D1A_dopamine_R	22..344	CDD:320443	131/324 (40%)
		TM helix 1	25..49	CDD:320443	10/24 (42%)
		TM helix 2	59..81	CDD:320443	12/21 (57%)
		TM helix 3	96..118	CDD:320443	11/21 (52%)
		TM helix 4	141..157	CDD:320443	6/15 (40%)
		TM helix 5	191..214	CDD:320443	10/22 (45%)
		TM helix 6	270..292	CDD:320443	11/21 (52%)
		TM helix 7	313..338	CDD:320443	13/25 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010