DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta1R and adrb2

DIOPT Version :9

Sequence 1:	NP_001262843.1	Gene:	Octbeta1R / 42652	FlyBaseID:	FBgn0038980	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001116897.2	Gene:	adrb2 / 100144654	XenbaseID:	XB-GENE-494302	Length:	419	Species:	Xenopus tropicalis

Alignment Length:	389	Identity:	137/389 - (35%)
Similarity:	209/389 - (53%)	Gaps:	40/389 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 SVEDVVAGQAQDIQASEGSTDDADGSSHLALVFVKCFIIGFIILAAILGNMLVIVSVMRHRKLRI 140
            ::|.:|:..:....||     |..|.:.:..:.:   |:..|:|..:|||:|||.::.:.::|:.
Frog    14 TLEQLVSNVSNTSNAS-----DKPGDAWMVGMGI---IMSCIVLVIVLGNVLVITAIAKFQRLQT 70

  Fly   141 ITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDR 205
            :||||:.|||.||:|:.|..:.|.||.:|...|:|.:..|:.|.|.|:...||||..||.|:|||
Frog    71 VTNYFITSLACADLLMGLIVVPFGASSIILDTWVFNNFWCEFWTSVDILCVTASIETLCVIAVDR 135

  Fly   206 YYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWY-TTTENYKYLKSNPHICEFKVN 269
            |:||..|..|..::|:.:..|::|:||:...|.|||||...|| ...|:..:...:|..|.|..|
Frog   136 YFAITSPFRYQSLLTKCKARIVILLVWVVSTLTSFLPIYMHWYRIEEESALHCYDDPSCCFFFTN 200

  Fly   270 KAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQISQIPKPRPSIQV 334
            .||||.||.:||::|.:||:.:|.|::|||.:|.:.:.:|:.     ..|.|.:|  :.....|.
Frog   201 PAYAISSSIISFYLPLVVMIFVYARVFQEAKKQLKKIDKSEG-----RFHNQNNQ--QDTNGKQG 258

  Fly   335 EQSTISTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSAL 399
            .:.|.....:|.||.:||||||..|.:||||||:..||..:....| |..:...|.|:||.|||.
Frog   259 NKRTSKFWLKEHKALKTLGIIMGTFTLCWLPFFIVNIVQVMHKDFI-PVKVYNFLNWVGYVNSAF 322

  Fly   400 NPIIYAYFNRDFRAAFKKTLKSLFPYAFYFCRRGRGRDDDRDLEFGGPSRRGTNGAQRTGSGSA 463
            ||:||.. :.|||..|::.|          |.|..|            |:...||..::...||
Frog   323 NPLIYCR-SPDFRYTFQELL----------CLRKPG------------SKAYANGYPQSNGNSA 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_001262843.1	7tm_4	112..>231	CDD:304433	49/118 (42%)
Octbeta1R	NP_001262843.1	7tm_1	124..404	CDD:278431	112/280 (40%)
adrb2	NP_001116897.2	7tmA_Beta2_AR	38..337	CDD:341355	121/310 (39%)
		TM helix 1	39..65	CDD:341355	9/28 (32%)
		TM helix 2	72..99	CDD:341355	14/26 (54%)
		TM helix 3	110..140	CDD:341355	16/29 (55%)
		TM helix 4	152..175	CDD:341355	10/22 (45%)
		TM helix 5	200..232	CDD:341355	17/31 (55%)
		TM helix 6	267..297	CDD:341355	17/29 (59%)
		TM helix 7	306..331	CDD:341355	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm14086
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X822
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010