DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta1R and drd1c

DIOPT Version :9

Sequence 1:	NP_001262843.1	Gene:	Octbeta1R / 42652	FlyBaseID:	FBgn0038980	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_004915948.1	Gene:	drd1c / 100124855	XenbaseID:	XB-GENE-5919679	Length:	465	Species:	Xenopus tropicalis

Alignment Length:	338	Identity:	134/338 - (39%)
Similarity:	195/338 - (57%)	Gaps:	27/338 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 DAD-GSSHLALVFVKCFIIGFIILAAILGNMLVIVSVMRHRKLRI-ITNYFVVSLAVADMLVALC 159
            |.| |||.|:|..:...::..:||:.:|||.||.::|::.|.||. :||:||:||||:|:.|||.
Frog    17 DLDVGSSDLSLRALTGLLLSLLILSTLLGNTLVCLAVIKFRHLRSKVTNFFVISLAVSDLFVALL 81

  Fly   160 AMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRV 224
            .|.:.|...::|.|:||. .||.|.:||:..|||||::||.||:|||:||..|..|...||||..
Frog    82 VMPWKAVTEVAGYWLFGD-FCDTWVAFDIMCSTASILNLCIISLDRYWAIASPFRYERKMTQRVA 145

  Fly   225 FIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHI--CEFKVNKAYAIVSSSMSFWIPGIV 287
            |||:.:.|....|:||:|:...|:.:.|..:.|.:..|.  |:..:|:.|||.||.:||:||.::
Frog   146 FIMIGVAWTLSILISFIPVQLSWHKSQEVDEELNAINHTENCDSSLNRTYAISSSLISFYIPVVI 210

  Fly   288 MLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQISQIPKPRPSIQVEQSTISTMRRERKAARTL 352
            |:..|.|||:.|..|.|.:..       ||:.::.:|  ...|....|.|..::.|:|.|..:||
Frog   211 MIGTYTRIYRIAQTQIRRISS-------LERAVEHAQ--SGHPDCSNENSLKTSFRKETKVLKTL 266

  Fly   353 GIIMSAFLICWLPFFLWYIVSSLC-----------DSCITPRLLVGILFWIGYFNSALNPIIYAY 406
            .|||..|:.||||||:...:...|           ..|:: .....|..|.|:.||:|||:|||
Frog   267 SIIMGVFVFCWLPFFVLNCMIPFCHMSLPGQNEPEPPCVS-ETTFNIFVWFGWANSSLNPVIYA- 329

  Fly   407 FNRDFRAAFKKTL 419
            ||.|||.||...|
Frog   330 FNADFRKAFTTIL 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_001262843.1	7tm_4	112..>231	CDD:304433	57/119 (48%)
Octbeta1R	NP_001262843.1	7tm_1	124..404	CDD:278431	113/293 (39%)
drd1c	XP_004915948.1	7tmA_D1-like_dopamine_R	46..338	CDD:320185	120/303 (40%)
		TM helix 2	64..91	CDD:320185	14/26 (54%)
		TM helix 3	101..131	CDD:320185	18/29 (62%)
		TM helix 4	143..163	CDD:320185	8/19 (42%)
		TM helix 5	192..222	CDD:320185	15/29 (52%)
		TM helix 6	257..287	CDD:320185	15/29 (52%)
		TM helix 7	307..332	CDD:320185	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010