DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta1R and adrb2b

DIOPT Version :9

Sequence 1:	NP_001262843.1	Gene:	Octbeta1R / 42652	FlyBaseID:	FBgn0038980	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001082940.2	Gene:	adrb2b / 100037315	ZFINID:	ZDB-GENE-070410-32	Length:	409	Species:	Danio rerio

Alignment Length:	431	Identity:	138/431 - (32%)
Similarity:	221/431 - (51%)	Gaps:	60/431 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 EGLGSAVGSGSSIAVSVEDVVAG--QAQDIQASEGSTDDADGSSHLALVFVKCFIIGFIILAAIL 123
            ||..:.:...:|:.:::.   ||  .:..:..|.....||:       |.:...:||.::|..:.
Zfish     2 EGDNTLITENTSLYMNIS---AGLNASSPVSLSVSEYSDAE-------VVLISILIGILVLVIVF 56

  Fly   124 GNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDV 188
            ||.|||.:::|.::|:.:||||:.|||.||:::.|..:.|.|..::...|.||:..|:.|.:.||
Zfish    57 GNALVISAIVRFQRLQTVTNYFISSLACADLVMGLMVVPFGACYILLNTWHFGNFFCEFWTATDV 121

  Fly   189 YFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTE- 252
            ...||||..||.|::|||.||:.||.|..::|:|:...|::.||...||:|||||...|:.:.|
Zfish   122 LCVTASIETLCVIALDRYIAIMWPLRYQSMLTKRKACGMVIGVWAVAALISFLPIHMEWWVSDEP 186

  Fly   253 NYKYLKSNPHICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLE 317
            ........|..|:|..|.|||:.||.:||:||.::|..:|.|::|||.||.:.:.|       :|
Zfish   187 EALSCLEEPTCCDFNTNAAYAVTSSIISFYIPLVIMAFVYSRVFQEARRQLQKIDR-------IE 244

  Fly   318 KHLQISQIPKPRPSIQVEQSTISTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSL--CDSCI 380
            ..:: :|....:...:::........::.||.:||||||..|.:||||||:..:|:::  .|:.:
Zfish   245 GRIR-TQSLSTQEGNEIKNRRTKFCMKDHKALKTLGIIMGTFTLCWLPFFVLNVVAAIWKMDNIM 308

  Fly   381 TPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKTLKSLFPYAFYFCRRGRGRDDDRDLEFG 445
            .|   ..||.||||.|||.||:||.. :.:||.||::.|          |.|....
Zfish   309 LP---FRILNWIGYANSAFNPLIYCR-SPEFRCAFQEIL----------CWRPSHL--------- 350

  Fly   446 GPSRRGTNGAQRTGSGSAEMANCVNSTASSEIHMSVMRARQ 486
             ||.|...|...:|.             |.::|....|.|:
Zfish   351 -PSTRSKKGYLYSGH-------------SWKVHTKTTRPRE 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta1R	NP_001262843.1	7tm_4	112..>231	CDD:304433	47/118 (40%)
Octbeta1R	NP_001262843.1	7tm_1	124..404	CDD:278431	108/282 (38%)
adrb2b	NP_001082940.2	7tm_GPCRs	41..339	CDD:333717	115/309 (37%)
		TM helix 1	43..67	CDD:320095	8/23 (35%)
		TM helix 2	76..98	CDD:320095	10/21 (48%)
		TM helix 3	114..136	CDD:320095	10/21 (48%)
		TM helix 4	159..175	CDD:320095	7/15 (47%)
		TM helix 5	204..227	CDD:320095	10/22 (45%)
		TM helix 6	272..297	CDD:320095	15/24 (63%)
		TM helix 7	308..333	CDD:320095	14/28 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X822
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010