DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tHMG2 and Tox4

DIOPT Version :9

Sequence 1:	NP_001163689.1	Gene:	tHMG2 / 42651	FlyBaseID:	FBgn0038979	Length:	134	Species:	Drosophila melanogaster
Sequence 2:	NP_775446.2	Gene:	Tox4 / 286990	RGDID:	708449	Length:	619	Species:	Rattus norvegicus

Alignment Length:	116	Identity:	33/116 - (28%)
Similarity:	58/116 - (50%)	Gaps:	16/116 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PKKPMSAFMLWMNSTGRKNIRAEHPDFSVQEVSVKGGEMWRAMADEHKIVWQ---ESAS----KA 66
            |:||:||:.|:...| :..|:.::|:.:..|||.....||.::.:|.|.|::   |:|.    ||
  Rat   223 PQKPVSAYALFFRDT-QAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKA 286

  Fly    67 MAEYKEKLE--------KWNAFKEHQTESFPHIYEAPLSSRFSKTNQRPTL 109
            :|.||:..|        :.:...:.||.|.|.:..|..:|....:.:.|.|
  Rat   287 LAAYKDNQECQATVETVELDPVPQSQTPSPPPVTTADPASPAPASTESPAL 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tHMG2	NP_001163689.1	HMGB-UBF_HMG-box	9..75	CDD:238686	24/72 (33%)
Tox4	NP_775446.2	NHP6B	140..>306	CDD:227935	25/83 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..227		2/3 (67%)
		Nuclear localization signal. /evidence=ECO:0000255	213..218
		HMG-box	223..288	CDD:238037	21/65 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..335		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..458
		PHA03160	<464..530	CDD:165431
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810