DRSC/TRiP Functional Genomics Resources

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Protein Alignment tHMG1 and HMGB2

DIOPT Version :9

Sequence 1:NP_651055.1 Gene:tHMG1 / 42650 FlyBaseID:FBgn0038978 Length:126 Species:Drosophila melanogaster
Sequence 2:NP_001124160.1 Gene:HMGB2 / 3148 HGNCID:5000 Length:209 Species:Homo sapiens


Alignment Length:68 Identity:27/68 - (39%)
Similarity:41/68 - (60%) Gaps:5/68 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 PKKPMSAFMLWMNSTGRKHIKAEHPDFSVQEVSVKGGEMWRAMADEDKIVWQESATTAMAEYKEK 72
            ||:|.|||.|:. |..|..||:|||..|:.:.:.|.||||...:.:||..:::.|    |:.|||
Human    95 PKRPPSAFFLFC-SEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKA----AKLKEK 154

  Fly    73 LKQ 75
            .::
Human   155 YEK 157

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tHMG1NP_651055.1 HMGB-UBF_HMG-box 8..74 CDD:238686 27/65 (42%)
Herpes_U55 <55..>116 CDD:253772 6/21 (29%)
HMGB2NP_001124160.1 HMG_box_2 6..78 CDD:401091
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 52..150 23/59 (39%)
HMG_box 95..162 CDD:395407 27/68 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 162..209
Required for chemotactic activity. /evidence=ECO:0000269|PubMed:19811285 165..180
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5648
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1641977at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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