DRSC/TRiP Functional Genomics Resources

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Protein Alignment tHMG1 and Hmgb1

DIOPT Version :9

Sequence 1:NP_651055.1 Gene:tHMG1 / 42650 FlyBaseID:FBgn0038978 Length:126 Species:Drosophila melanogaster
Sequence 2:NP_001300823.1 Gene:Hmgb1 / 15289 MGIID:96113 Length:215 Species:Mus musculus


Alignment Length:68 Identity:29/68 - (42%)
Similarity:41/68 - (60%) Gaps:5/68 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 PKKPMSAFMLWMNSTGRKHIKAEHPDFSVQEVSVKGGEMWRAMADEDKIVWQESATTAMAEYKEK 72
            ||:|.|||.|:. |..|..||.|||..|:.:|:.|.||||...|.:||..:::.|    |:.|||
Mouse    95 PKRPPSAFFLFC-SEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKA----AKLKEK 154

  Fly    73 LKQ 75
            .::
Mouse   155 YEK 157

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
tHMG1NP_651055.1 HMGB-UBF_HMG-box 8..74 CDD:238686 29/65 (45%)
Herpes_U55 <55..>116 CDD:253772 6/21 (29%)
Hmgb1NP_001300823.1 Sufficient for interaction with HAVCR2. /evidence=ECO:0000269|PubMed:22842346 1..97 1/1 (100%)
Heparin-binding. /evidence=ECO:0000250|UniProtKB:P10103 1..10
LPS binding (delipidated). /evidence=ECO:0000250|UniProtKB:P09429 3..15
HMG_box_2 6..78 CDD:401091
NLS 1. /evidence=ECO:0000250|UniProtKB:P63159 27..43
Nuclear localization signal (NLS) 1. /evidence=ECO:0000250|UniProtKB:P63159 27..43
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 76..95 29/68 (43%)