DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT1 and CCT2

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_012124.1	Gene:	CCT2 / 854664	SGDID:	S000001404	Length:	527	Species:	Saccharomyces cerevisiae

Alignment Length:	538	Identity:	177/538 - (32%)
Similarity:	297/538 - (55%)	Gaps:	41/538 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 TRQSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDV-TVTNDGATILRLLEVEHPAAK 76
            |.:...:.|....:.|:::.::|||:|||.|:||:|.....:. .|||||||||:.:.:::||||
Yeast    11 TEERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDGATILKSIPLDNPAAK 75

  Fly    77 VLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQ-KIHPTSIISGYRIACKEACKYISEHLT 140
            |||.::::||:|||||||||.:|:||||:.|::|:.| ||||.:||.|||:|...|...:::
Yeast    76 VLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTIIEGYRLASAAALDALTK--- 137

  Fly   141 APVDE-----LGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKAINV 200
            |.||.     :.|:.||:||||::||||:..|.:.|:.:..:|...:|       .:.:::.|.:
Yeast   138 AAVDNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNAILRLK-------GSTNLEHIQI 195

  Fly   201 LKAHGKSARESVLIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKMKM-GVQVLINDPDKLE 264
            :|..|....:|.|..|:.|.....:.| ||:|.||||...:.:|...|:|: |.:..::...||.
Yeast   196 IKILGGKLSDSFLDEGFILAKKFGNNQ-PKRIENAKILIANTTLDTDKVKIFGTKFKVDSTAKLA 259

  Fly   265 AIRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATGAA 329
            .:...|.:..|.:|..|...|:|..:....:.|...:.|.:.|..::.......::.:|..||..
Yeast   260 QLEKAEREKMKNKIAKISKFGINTFINRQLIYDYPEQLFTDLGINSIEHADFEGVERLALVTGGE 324

  Fly   330 FITSLTNMDGEESFD---ASMVGEAAEVAQERICDDELILIKGTKARAAASIILRGPNDFYCDEM 391
            .::         :||   ...:||...:.:..:.:...:...|.||..|.:|:|||..|...||.
Yeast   325 VVS---------TFDEPSKCKLGECDVIEEIMLGEQPFLKFSGCKAGEACTIVLRGATDQTLDEA 380

  Fly   392 ERSVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKTLS 456
            |||:||||.|:.:..:..:.|.||||.|..:|..::..|.::..::.||:..||::|..:|..|:
Yeast   381 ERSLHDALSVLSQTTKETRTVLGGGCAEMVMSKAVDTEAQNIDGKKSLAVEAFARALRQLPTILA 445

  Fly   457 VNAAKDATDLVAKLR-SYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKFA 520
            .||..|:::||:||| |.:|...|         :||||..|.:.|.::.|::|....|...:..|
Yeast   446 DNAGFDSSELVSKLRSSIYNGIST---------SGLDLNNGTIADMRQLGIVESYKLKRAVVSSA 501

  Fly   521 TEAAITILRIDDMIKLNP 538
            :|||..:||:|::|:..|
Yeast   502 SEAAEVLLRVDNIIRARP 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	176/536 (33%)
CCT2	NP_012124.1	TCP1_beta	5..520	CDD:239452	177/538 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820