DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT1 and CCT5

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_012598.1	Gene:	CCT5 / 853527	SGDID:	S000003825	Length:	562	Species:	Saccharomyces cerevisiae

Alignment Length:	535	Identity:	172/535 - (32%)
Similarity:	293/535 - (54%)	Gaps:	33/535 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RQSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEVEHPAAKVL 78
            ||.|...:..:::||.|:::|:|:||||.||||:|:...|::|:||||||||..:|:::..||:|
Yeast    40 RQHGLEAKKSHILAARSVASIIKTSLGPRGLDKILISPDGEITITNDGATILSQMELDNEIAKLL 104

  Fly    79 VELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACKYISE---HLT 140
            |:|::.||:|:|||||.||:||:.||..|.||:::.|||..|.:|:..|.|.|...:.|   .::
Yeast   105 VQLSKSQDDEIGDGTTGVVVLASALLDQALELIQKGIHPIKIANGFDEAAKLAISKLEETCDDIS 169

  Fly   141 APVDELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKAINVLKAHG 205
            |..|||.||.|:..||||:.|||:..|.:.|:.|.|:|..:|...|.:.      ...:::|..|
Yeast   170 ASNDELFRDFLLRAAKTSLGSKIVSKDHDRFAEMAVEAVINVMDKDRKD------VDFDLIKMQG 228

  Fly   206 K---SARESVLIPGYALNCTIASQQMPKKIV------NAKIACLDFSLQKTKMKMGVQVLINDPD 261
            :   |..:|.||.|..|:...:..||||.::      ..|:|.|....:..|.|...::.|:..:
Yeast   229 RVGGSISDSKLINGVILDKDFSHPQMPKCVLPKEGSDGVKLAILTCPFEPPKPKTKHKLDISSVE 293

  Fly   262 KLEAIRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKAT 326
            :.:.::..|.|..||.|:.:...|.:||:...|.||......::....|||.|...:|:.||.:|
Yeast   294 EYQKLQTYEQDKFKEMIDDVKKAGADVVICQWGFDDEANHLLLQNDLPAVRWVGGQELEHIAIST 358

  Fly   327 GAAFITSLTNMDGEESFDASMVGEAAEVAQERI--CDDELILIKGTKARAAASIILRGPNDFYCD 389
            ....:....::..::      :|..:.:.::..  ..|.:::|:.:|.....:..:||.|....|
Yeast   359 NGRIVPRFQDLSKDK------LGTCSRIYEQEFGTTKDRMLIIEQSKETKTVTCFVRGSNKMIVD 417

  Fly   390 EMERSVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKT 454
            |.||::||:||||:.:::..:||.|||..|..:|:.:...|......:|.|...||::|..||.|
Yeast   418 EAERALHDSLCVVRNLVKDSRVVYGGGAAEVTMSLAVSEEADKQRGIDQYAFRGFAQALDTIPMT 482

  Fly   455 LSVNAAKDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKF 519
            |:.|:..|....::.|:    |.|.|.:.|::   |:|.:.....|.|:..|::|.:.|.:.:..
Yeast   483 LAENSGLDPIGTLSTLK----SKQLKEKISNI---GVDCLGYGSNDMKELFVVDPFIGKKQQILL 540

  Fly   520 ATEAAITILRIDDMI 534
            ||:....||:||::|
Yeast   541 ATQLCRMILKIDNVI 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	172/535 (32%)
CCT5	NP_012598.1	TCP1_epsilon	23..555	CDD:239455	171/533 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820