DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT1 and CCT3

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_012520.1	Gene:	CCT3 / 853438	SGDID:	S000003551	Length:	534	Species:	Saccharomyces cerevisiae

Alignment Length:	540	Identity:	164/540 - (30%)
Similarity:	279/540 - (51%)	Gaps:	45/540 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RQSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEVEHPAAKVL 78
            |.:|...:..|:.||.::::::::.|||..:.|||:|.:|.:.:||||..|||.::|.|||||.:
Yeast    14 RTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSM 78

  Fly    79 VELAQLQDEEVGDGTTSVVILAAELLKN-ADELVKQKIHPTSIISGYRIACKEACKYISEHLTAP 142
            :||::.||||||||||:|:|||.|:|.. |..|:::.|||..||...:.|..:|.:.|.: ::.|
Yeast    79 LELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQ-VSKP 142

  Fly   143 VDELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKI---TDPRGQAAYSI---KAINVL 201
            ||.....::..:.:.|:.:|.:...:|....:.:||.::|:.   ....|:..:.|   :.:.|.
Yeast   143 VDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDIKRYVRVE 207

  Fly   202 KAHGKSARESVLIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKMKMGVQVLINDPDKLEAI 266
            |..|....:|.::.|..||..:...:|.:.|.|.::..||..|:..|.:....:.|...:....|
Yeast   208 KIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRI 272

  Fly   267 RARELDITKERINM----ILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATG 327
                |.|.:|::.:    ||.....:|:...||.||...|.::.|...:|||||||...||:.||
Yeast   273 ----LQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTG 333

  Fly   328 AAFITSLTNMDGEES--------FDASMVGEAAEVAQERICDDELILIKGTKARAAASIILRGPN 384
            |..:..:.::  :||        |...|:|           |:....:...|...|.:|:|||.:
Yeast   334 ATIVNRVEDL--KESDVGTNCGLFKVEMIG-----------DEYFSFLDNCKEPKACTIMLRGGS 385

  Fly   385 DFYCDEMERSVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLL 449
            ....:|::|::.||:.|.:.|:.|..:..|||..|.|:|:.|...|..|...:|......|.::.
Yeast   386 KDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAME 450

  Fly   450 VIPKTLSVNAAKDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKI 514
            .||:||..||..|...|:::||:.|......        ||:|..:|.:.|....|:.||.:.|.
Yeast   451 CIPRTLIQNAGGDPIRLLSQLRAKHAQGNFT--------TGIDGDKGKIVDMVSYGIWEPEVIKQ 507

  Fly   515 KSLKFATEAAITILRIDDMI 534
            :|:|.|.|:|..:||:||::
Yeast   508 QSVKTAIESACLLLRVDDIV 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	164/540 (30%)
CCT3	NP_012520.1	chap_CCT_gamma	4..533	CDD:274085	164/540 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810