DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT1 and CCT4

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_010138.1	Gene:	CCT4 / 851412	SGDID:	S000002302	Length:	528	Species:	Saccharomyces cerevisiae

Alignment Length:	535	Identity:	165/535 - (30%)
Similarity:	288/535 - (53%)	Gaps:	39/535 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RQSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEVEHPAAKVL 78
            ::....||..|::||.|:::.:::||||.|:|||:....|::.::|||.|||:.:.:.||.|::|
Yeast    14 KEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARML 78

  Fly    79 VELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACKYISE--HLTA 141
            ||::..||.|.||||||||||...||..|:.|:.:.||||.|...::.|.|.:...:.|  |..:
Yeast    79 VEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVS 143

  Fly   142 PVDELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKAINVLKAHGK 206
            ..|   |:.|:..|.||:||||:...:.|.:.:.||:.  :||:|...:.. .:..|.::|..|.
Yeast   144 LSD---REQLVRAASTSLSSKIVSQYSSFLAPLAVDSV--LKISDENSKNV-DLNDIRLVKKVGG 202

  Fly   207 SARESVLIPGYALNCT-IASQQMPKKIVNAKIACLDFSLQKTKMKMGVQVLINDPDKLEAI---- 266
            :..::.:|.|..|..| |.|...|.:...|||..:.|.:...|......:::||..:::.|
Yeast   203 TIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEE 267

  Fly   267 RARELDITKE----RINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATG 327
            ||..|:|.|:    :.|::|   :...::...|:||.:.:..:...|.|:.:::.:::.::|..|
Yeast   268 RAYLLNICKKIKKAKCNVLL---IQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLG 329

  Fly   328 AAFITSLTNMDGEESFDASMVGEAAEVAQERICDDELIL----IKGTKARAAASIILRGPNDFYC 388
            ...|..:      |.|....:| :|::.:|...|...|:    |:...||...|:::||.|:...
Yeast   330 CKPIADI------ELFTEDRLG-SADLVEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMII 387

  Fly   389 DEMERSVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPK 453
            ||.|||:||||||::.:::.:.::||||..|..:|..|...|.|:...:.....|||.:|.|||.
Yeast   388 DETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPT 452

  Fly   454 TLSVNAAKDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLK 518
            ||:.||..::..:|.:|||.|.:.    |.:|    |:.:......:..:..:|:|.:....::.
Yeast   453 TLAENAGLNSIKVVTELRSKHENG----ELND----GISVRRSGTTNTYEEHILQPVLVSTSAIT 509

  Fly   519 FATEAAITILRIDDM 533
            .|:|...:||||||:
Yeast   510 LASECVKSILRIDDI 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	165/535 (31%)
CCT4	NP_010138.1	chap_CCT_delta	11..528	CDD:274083	165/535 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820