DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT1 and Mkks

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_001135418.1	Gene:	Mkks / 59030	MGIID:	1891836	Length:	570	Species:	Mus musculus

Alignment Length:	588	Identity:	118/588 - (20%)
Similarity:	225/588 - (38%)	Gaps:	103/588 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 TQNVMAALSI-SNIVKSSLGPVGLDKMLVDDIGD-VTVTNDGATILRLLEVEHPAAKVLVELAQL 84
            ::.|.:.||: ..::.|..||.|..|.|.:.:|. |..|:..:.:||.|.|.||..|:|....|.
Mouse    19 SEKVRSTLSVLKGVIASCYGPSGRLKQLHNGLGGCVYTTSQSSALLRNLSVTHPVLKILTSSVQN 83

  Fly    85 QDEEVGDGTTSVVILAAELLKNADEL-------VKQKIHPTSIISGYRIACKEACKYISEHLTAP 142
            ......|......||...|::|...|       :|...:..|:.:.|  ...|||.     ...|
Mouse    84 HVSCFSDCGLFTAILCCNLIENIQRLDLTPATAIKLNKYLLSLCTSY--LKSEACS-----CRIP 141

  Fly   143 VDELGRDSLINIAKTSMSSK----IIGADAEFFSAMVVDAAQSVKITDPRGQAAYSI--KAINVL 201
            ||.....:.:::..:.::||    :...:.:...|:::.|   ..:|.|.......:  |:| ::
Mouse   142 VDFRSTHTFLSLVHSILTSKPACMLTRKETDHIGALILKA---FLLTIPESTEERMVLGKSI-IV 202

  Fly   202 KAHGKSARESVLIPGYALNCTIASQQMPKKIVNAKIA--------CLDFSLQKTKMKMGVQVLIN 258
            ...|:...:|.::||..:.   ||:...::::..:.|        |...|...:....||.|...
Mouse   203 PLKGQRVTDSTVLPGLLIE---ASEVQLRRLLPTQKASGLRVALFCTSLSGDFSNAGEGVVVAHY 264

  Fly   259 DPDKLEAIRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIA 323
            ......|:..:.|::.:.    ::...|::||....:.....::|.|...||:.||..:.::.::
Mouse   265 QVSLENAVLEQLLNLGRR----LVTDHVDLVLCQKVIHPSLKQFFSERHVMAIDRVGVTLMESLS 325

  Fly   324 KATGAAFITSLTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKARAAASIILRGPNDFYC 388
            |.|||..|.||      ....::..|...:|...|........:...:| ...:::|...||...
Mouse   326 KVTGATPIGSL------NPIVSTTYGSVKDVCSARFGSKHFFHLLPNEA-TVCTLLLCSRNDTAW 383

  Fly   389 DEMERSVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLA-----------SREQLAIA 442
            :|::.:...|:.|::..::...|:.||||.|..|:.|:.:.....|           ::..:|..
Mouse   384 EELKLTCQTAMHVLQLTIKEPWVLLGGGCTETHLAAYVRHKVHHEAEAIVRDDGCTQAKLHVAAE 448

  Fly   443 EFAKSLLVIPKTLSVNAAKDATD--------LVAKLRSYHNSSQTKP--------ERSDLKWTGL 491
            .|..:|..:..:|..:..:...|        ..|...|..|.|.|..        .:.:|.|:
Mouse   449 AFCSALESVAGSLEHDGGEILIDTKYGHLWSCQADSASVGNWSDTLSRCGCGLYNSQEELSWS-- 511

  Fly   492 DLIEGVVRDNKKAGVLEPAM-----------------SKIKSLKFATEAAITILRIDDMIKLNPE 539
                 |:|........:..:                 :|:..|:.|.|.|..||.:..:|    |
Mouse   512 -----VLRSTYHPFAPQTCLPQAALGSASNLTVDCFTAKLSGLQVAVETANLILDLSYVI----E 567

  Fly   540 DKS 542
            ||:
Mouse   568 DKN 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	115/582 (20%)
Mkks	NP_001135418.1	Cpn60_TCP1	29..569	CDD:395068	113/575 (20%)
Mkks	NP_001135418.1	Substrate-binding apical domain. /evidence=ECO:0000250\|UniProtKB:Q9NPJ1	198..370		36/186 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810