DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT1 and Hsp60B

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_524925.1	Gene:	Hsp60B / 48572	FlyBaseID:	FBgn0011244	Length:	648	Species:	Drosophila melanogaster

Alignment Length:	605	Identity:	128/605 - (21%)
Similarity:	234/605 - (38%)	Gaps:	138/605 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PLSIAGTR----------QSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDG 61
            |.:|..:|          :.|:.||...:.....:::.|..::||.|...::........:|.||
  Fly     7 PKAITSSRCFARMYSKDVRFGSGVRAMMIRGVDILADAVAVTMGPKGRSVIVERPWTSPKITKDG 71

  Fly    62 ATILR--LLEVEHP--AAKVLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIIS 122
            .|:.|  .|:.:|.  .||::.::|...:|..|||||:..:||..:.|.....:....:|..|..
  Fly    72 FTVARSIALKDQHMNLGAKLVQDVADNTNESAGDGTTTATVLARAIAKEGFNQITMGANPVEIRR 136

  Fly   123 GYRIA---CKEACKYISEHLTAPVDELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKI 184
            |..:|   .|:..|.:|:.:..      |:.:..:|..|.:     .|.| ...::.:|...|
  Fly   137 GVMLAVDVVKDKLKEMSKAVET------REEIQQVATLSAN-----GDTE-IGRLIGEATDKV-- 187

  Fly   185 TDPRGQAAYSIKAINVLKAHGKSARESVLI-------PGYALNCTIASQQMPK-KIVNAKIACLD 241
             .|||         .:....||..::.:.|       .||.....:.|.:..| :..||.:.
  Fly   188 -GPRG---------TITVKDGKRLKDELNIIQGLRFDNGYVSPFFVNSSKGSKVEFANALVM--- 239

  Fly   242 FSLQKTKMKMGVQVLINDPDKLEAIRARE------LDITKERINMI----LGTGVNVVLVSGGVD 296
            .||:|.   .|:..::...:  :::|.|.      .||:.|.:|.:    |..|:.|..|.
  Fly   240 ISLKKI---TGLSQIVKGLE--QSLRQRRPLIIIAEDISGEALNALVLNKLRLGLQVCAVK---- 295

  Fly   297 DLCMKYFVEAGAMAVRRVKKSDLKIIAKATGAAFI---TSLTNMDGEESFDASMVGEAA------ 352
                       :.:....:|..:..|:.||||...   .:.:.|:..:..|...||||.
  Fly   296 -----------SPSYGHHRKELIGDISAATGATIFGDDINYSKMEEAKLEDLGQVGEAVISKDST 349

  Fly   353 ---------------------EVAQERICDDELILIK---GTKARAAASIILRGPNDFYCDEMER 393
                                 |:|:::|..::...::   ....:..|.:.:.|.::...:|.:.
  Fly   350 MLLQGKPKTGLLEMRIQQIQDELAEKQIKPEQRDRLRQRLSALTKGVAVLHIGGGSEVEVNEKKD 414

  Fly   394 SVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKTLSVN 458
            .|.|||...:..:| :.:|.|||........||:...|..|.. |..:.....:|.:..:|::.|
  Fly   415 RVVDALNATRAAIE-EGIVPGGGTAFLRCIPYLQELKTESADL-QKGVDIVCNALRMPCQTIAQN 477

  Fly   459 AAKDATDLVAKLRSYHNSSQTKPERSDLKWTGLD-----LIE-GVVRDNKKAGVLEPAMSK---I 514
            |..|...:|||:.   |.|:      |..:..:.     |:| |::...|   ||..|::.   :
  Fly   478 AGVDGPMVVAKVL---NGSE------DYGYDAMGDEYCRLVEKGIIDPTK---VLRTAITDAAGV 530

  Fly   515 KSLKFATEAAITILRIDDMI 534
            .||...||..||..|.||::
  Fly   531 ASLLSTTEVVITDSRNDDLL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	126/600 (21%)
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	127/603 (21%)
Hsp60B	NP_524925.1	GroEL	22..543	CDD:239460	121/581 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453464
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740