DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT1 and CCT3

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	174/535 - (32%)
Similarity:	287/535 - (53%)	Gaps:	43/535 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RQSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEVEHPAAKVL 78
            |:||..|:.:|:.|..:|::::::.|||..:.|||:|.:|.:.:||||..|||.:.|:|||||.:
  Fly    17 RESGRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAILREITVQHPAAKSM 81

  Fly    79 VELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACKYISEHLTAPV 143
            :|:|:.||||||||||||::||.|:|..|:..::|:||||.||..||.|.::...::...|:..:
  Fly    82 IEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAYREALEDIVGHLQSQLSIQL 146

  Fly   144 DELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKA-INVLKAHGKS 207
            |...:..:.::.|..:.:|.||..::....:.:||.::|.::: .|:....||. ..|.|..|.:
  Fly   147 DVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSE-NGRLEVDIKRYAKVEKIPGGA 210

  Fly   208 ARESVLIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKMKMGVQV-LINDPDKLEAIRAREL 271
            ..||.::.|..:|..:...:|.:.|.|.:|..||.||:..|.:....| :|.:.|     ..|.|
  Fly   211 IEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEIIGEQD-----FTRML 270

  Fly   272 DITKERINM----ILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATGAAFIT 332
            .|.:|.:..    |:....::|....||.||...|.::||..|:||::|:|...||:|.||..:.
  Fly   271 QIEEEFVQRICADIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRRLRKTDNLRIARACGATIVN 335

  Fly   333 ---SLTNMDGEESFDASMVGEAAEVAQ-ERICDDELILIKGTKARAAASIILRGPNDFYCDEMER 393
               .||..|         ||..|.:.: ::|.|:....:...|...|.:|:|||.:....:|.||
  Fly   336 RTEELTEKD---------VGTGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGASKDILNETER 391

  Fly   394 SVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQL--AIAEFAKSLLVIPKTLS 456
            ::.|||.|.:.::...::|||||.||.|        |:.|.:|:|:  .....|.:|.:||:||:
  Fly   392 NLQDALHVARNLVLEPRLVAGGGAVEMA--------ASQLLTRKQVKGPYTAVAHALEIIPRTLA 448

  Fly   457 VNAAKDATDLVAKLRSYHNSSQTKPERSD--LKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKF 519
            .|...:....:..||:.|.|     ...|  ..| |:|...|.:.|.....:.||...|:::.|.
  Fly   449 QNCGANTIRALTALRAKHAS-----HTGDGVCAW-GIDGESGEIVDMNVKNIWEPLAVKLQTYKT 507

  Fly   520 ATEAAITILRIDDMI 534
            |.|.||.:|||||::
  Fly   508 AVETAILLLRIDDIV 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	174/535 (33%)
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	174/535 (33%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	174/535 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453474
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38420at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11353
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850