DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT1 and cct4

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_956877.1	Gene:	cct4 / 393555	ZFINID:	ZDB-GENE-040426-1421	Length:	533	Species:	Danio rerio

Alignment Length:	529	Identity:	167/529 - (31%)
Similarity:	293/529 - (55%)	Gaps:	27/529 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RQSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEVEHPAAKVL 78
            |...|.:|..|:.|..::::.:::||||.|:|||:.|..||||:||||||||:.::|.|||||::
Zfish    21 RDKPAQIRYSNINAGKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAAKMM 85

  Fly    79 VELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACKYISEHLTAPV 143
            |||::.||.|.||||||||::|..||....:|:::.||||.|...::.|..:..:.::. ::.|:
Zfish    86 VELSKAQDIEAGDGTTSVVVIAGALLDACAKLLQKGIHPTIISESFQKAVDKGVEVLTS-ISTPL 149

  Fly   144 DELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKAINVLKAHGKSA 208
            ....|:||:|.|.||:.||::..::...:.|.|||.  :|:.||....:..::.|||:|..|.:.
Zfish   150 LLSDRESLLNSASTSLCSKVVSQNSSLLAPMSVDAV--MKVIDPATATSVDLRDINVVKKLGGTI 212

  Fly   209 RESVLIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKMKMGVQVLINDPDKLEAIRARELDI 273
            .:..|:.|..|...:||..: .::..|||..:.|.|...|..|..|::::|..:::.:...|...
Zfish   213 DDCELVDGMVLTQRVASTGV-SRVEKAKIGLIQFCLSPPKTDMDNQIVVSDYAQMDRVLREERAY 276

  Fly   274 TKERINMILGTGVNVVLVSGGV-----DDLCMKYFVEAGAMAVRRVKKSDLKIIAKATGAAFITS 333
            ....:..:...|..|:|:...:     .||.:.:..:...|.::.:::.:::.|.|..|...|..
Zfish   277 ILNLVKQVKKAGCTVLLIQKSILRDALSDLALHFLNKMKIMVIKDIEREEIEFICKTIGTKPIAH 341

  Fly   334 LTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKARA---AASIILRGPNDFYCDEMERSV 395
            :      :.|...|:| :||:.:|...|....|:|.|...:   ..||::||.|....:|.|||:
Zfish   342 I------DQFTPEMLG-SAELVEEVSLDGSGKLVKITGCASPGKTVSIVVRGSNKLVIEEAERSI 399

  Fly   396 HDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKTLSVNAA 460
            ||||||::.:::.:.::||||..|..|::.|..:|.||...|...:..:|.:|.|||.||:.||.
Zfish   400 HDALCVIRCLVKKRALIAGGGAPEIELALRLAEYARSLGGMEAYCVRAYADALEVIPSTLAENAG 464

  Fly   461 KDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKFATEAAI 525
            .:....|.:||:.|...:|.        .|:::.:|.:.:..:..|::|.:..|.:|..|||...
Zfish   465 LNPISTVTELRNRHAQGETT--------AGINVRKGGISNILEELVVQPLLVSISALTLATETVR 521

  Fly   526 TILRIDDMI 534
            :||:|||::
Zfish   522 SILKIDDLV 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	167/529 (32%)
cct4	NP_956877.1	TCP1_delta	20..532	CDD:239454	167/529 (32%)
cct4	NP_956877.1	Cpn60_TCP1	38..533	CDD:278544	162/512 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820