DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT1 and Cct6b

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	XP_017452911.1	Gene:	Cct6b / 363658	RGDID:	1359453	Length:	543	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	138/553 - (24%)
Similarity:	270/553 - (48%)	Gaps:	44/553 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LASPLSIAGTRQSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLL 68
            :|:|.:.....|:..:|   |:.||..:.::::.||||.|..||||...||:.:|.||..:|..:
  Rat     6 IANPGAEVTRSQAALAV---NICAARGLQDVLRPSLGPKGALKMLVSGAGDIKLTKDGNVLLHEM 67

  Fly    69 EVEHPAAKVLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACK 133
            :::||.|.::.::|..||...||||||.|::..||||.||..:.:.:||..|..|:.:|..:|.:
  Rat    68 QIQHPTASIIAKVAAAQDHITGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFDVAKTKALE 132

  Fly   134 YISEHLTAPVDELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKAI 198
            .:.:  .....|:.|:.|:::|:||:.:|:....|:..:..|||:..:::    |......:..:
  Rat   133 VLDK--IKVQKEMKREMLLDVARTSLRTKVHTELADILTEAVVDSVLAIR----RPGIPIDLFMV 191

  Fly   199 NVLKAHGKSARESV------------LIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKMKM 251
            .:::...||..::.            |:.|..|:......:|.|::.:|.|...:.||:..|.::
  Rat   192 EIVEMRHKSETDTQAGDRTQGLALPRLVRGLVLDHGARHPRMKKQVQDAYILICNVSLEYEKTEV 256

  Fly   252 GVQVLINDPDKLEAIRARELDITKERINMILGTGVN---------VVLVSGGVDDLCMKYFVEAG 307
            .........::.|.:...|....::|:..|:.....         ||:...|:|.:.::...:..
  Rat   257 SSGFFYKTVEEKEKLVKAERKFIEDRVQKIIDLKQKVCAESNKGFVVINQKGIDPVSLEMLAKHN 321

  Fly   308 AMAVRRVKKSDLKIIAKATGAAFITSLTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKA 372
            .:|:||.|:.:|:.:..|.|...:.||.::..|      .:|.|..|.:..:.:::...|:....
  Rat   322 IVALRRAKRRNLERLTLACGGLAVNSLEDLSEE------CLGHAGLVFEYTLGEEKFTFIEDCVN 380

  Fly   373 RAAASIILRGPNDFYCDEMERSVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASRE 437
            ..:.:::::|||.....:::.::.|.|..||..:|...||.|.|.||.|::..|.|:...:..|.
  Rat   381 PLSVTLLVKGPNKHTLIQIKDALRDGLRAVKNAIEDGCVVPGAGAVEVAIAEALVNYKHCVQGRA 445

  Fly   438 QLAIAEFAKSLLVIPKTLSVNAAKDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNK 502
            :|.|..||.:||:|||.|:.|:..|..:.:.|:::.|..|:        :..|:||..|......
  Rat   446 RLGIQAFADALLIIPKVLAQNSGYDLQETLIKIQTKHAESK--------ELVGIDLNTGEPMVAA 502

  Fly   503 KAGVLEPAMSKIKSLKFATEAAITILRIDDMIK 535
            :||:.:....|...|...|..|..:|.:|::::
  Rat   503 EAGIWDNYCVKKHILHSCTVIATNVLLVDEIMR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	136/545 (25%)
Cct6b	XP_017452911.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810